Characteristics of Disorder‐Related Autobiographical Memory in Acute Anorexia Nervosa Patients

Huber, Julia; Salatsch, Carmen; Ingenerf, Katrin; Schmid, Carolin; Maatouk, Imad; Weisbrod, Matthias; Herzog, Wolfgang; Friederich, Hans‐Christoph; Nikendei, Christoph

doi:10.1002/erv.2379

Cited by 26 publications

(35 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature on memory bias in patients with AN suggests no biases for memories triggered by depression-related words including “rejection” and “criticism” ( 57 ) and no differences in terms of frequency of negatively valenced memories ( 57 , 58 ) when patients are compared to healthy controls. However, there is some indication that patients with AN tend to recall fewer and more general (vs. specific) memories when these are cued by food- or body-related words ( 57 ). Taken together, these findings do not seem to suggest that negative interpersonal memories are easily biased in patients with eating disorders.…”

Section: Discussionmentioning

confidence: 99%

Social Difficulties As Risk and Maintaining Factors in Anorexia Nervosa: A Mixed-Method Investigation

et al. 2018

View full text Add to dashboard Cite

Anorexia nervosa (AN) is a serious psychiatric disorder characterized by severe restriction of energy intake and dangerously low body weight. Other domains of functioning are affected, including social functioning. Although difficulties within this domain have started to be acknowledged by the literature, some important gaps remain to be filled. Do social difficulties predate the onset of the illness? What difficulties in particular are relevant for the development and maintenance of the illness? The aim of this study is to combine the use of quantitative and qualitative methods to answer these questions. Ninety participants with lifetime AN (88 women and 2 men) completed an online survey assessing memories of involuntary submissiveness within the family, fear of negative evaluation from others, perceived lack of social competence, feelings of social belonging, eating disorder symptoms, and work and social adjustment. Participants also answered three open questions regarding their experience of social relationships before and after the illness onset. The findings provided support for the hypothesized relationships between the study variables. Involuntary submissiveness and fear of negative evaluation predicted eating disorder symptoms and these associations were partially mediated by perceived lack of social competence. Two-thirds of the sample recalled early social difficulties before illness onset and recognized that these had played a role in the development of the illness. A larger proportion of participants stated that the eating disorder had affected their social relationships in a negative way. This study sheds some light on patients’ perspective on the predisposing and maintaining role that social difficulties play in AN and identifies key psychological variables that could be targeted in treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Social Difficulties As Risk and Maintaining Factors in Anorexia Nervosa: A Mixed-Method Investigation

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A power analysis was conducted using G*Power (version 3.1.9.2) (Faul, Erdfelder, Buchner, & Lang, 2009). On the basis of previous studies using word stimuli for memory performance in AN (Bomba et al, 2014;Huber et al, 2015), a medium to large effect size can be assumed for group differences between AN patients and CO healthy controls. For AN patients, differences in memory performance for the recall of various types of word stimuli have been shown, with large effect sizes.…”

Section: Sample Size Estimation and Power Analysismentioning

confidence: 99%

Meaningful Memory in Acute Anorexia Nervosa Patients—Comparing Recall, Learning, and Recognition of Semantically Related and Semantically Unrelated Word Stimuli

Terhoeven

Kallen

Ingenerf

et al. 2016

Euro Eating Disorders Rev

Self Cite

View full text Add to dashboard Cite

show abstract

“…These alterations are likely to be involved in several changes observed: besides a reduction in food intake and body weight also an intestinal barrier dysfunction (Jésus et al, 2014), a disruption of neural development in the hippocampus (Chowdhury et al, 2014) and an impairment of memory function (Paulukat et al, 2016), increased anxiety (Kinzig and Hargrave, 2010) and the development of stress ulcers (Doerries et al, 1991), features also observed (Kline, 1979; Ghadirian et al, 1993; Swinbourne and Touyz, 2007; Huber et al, 2015; Kjaersdam Telleus et al, 2015) or suspected in patients with AN. Taken together, activity-based anorexia—despite the major limitation of being an animal model merely mimicking features of a disease—is likely a suited tool to study aspects of the pathogenesis of human AN.…”

Section: Introductionmentioning

confidence: 98%

Activity-Based Anorexia Reduces Body Weight without Inducing a Separate Food Intake Microstructure or Activity Phenotype in Female Rats—Mediation via an Activation of Distinct Brain Nuclei

et al. 2016

View full text Add to dashboard Cite

Anorexia nervosa (AN) is accompanied by severe somatic and psychosocial complications. However, the underlying pathogenesis is poorly understood, treatment is challenging and often hampered by high relapse. Therefore, more basic research is needed to better understand the disease. Since hyperactivity often plays a role in AN, we characterized an animal model to mimic AN using restricted feeding and hyperactivity. Female Sprague-Dawley rats were divided into four groups: no activity/ad libitum feeding (ad libitum, AL, n = 9), activity/ad libitum feeding (activity, AC, n = 9), no activity/restricted feeding (RF, n = 12) and activity/restricted feeding (activity-based anorexia, ABA, n = 11). During the first week all rats were fed ad libitum, ABA and AC had access to a running wheel for 24 h/day. From week two ABA and RF only had access to food from 9:00 to 10:30 a.m. Body weight was assessed daily, activity and food intake monitored electronically, brain activation assessed using Fos immunohistochemistry at the end of the experiment. While during the first week no body weight differences were observed (p > 0.05), after food restriction RF rats showed a body weight decrease: −13% vs. day eight (p < 0.001) and vs. AC (−22%, p < 0.001) and AL (−26%, p < 0.001) that gained body weight (+10% and +13%, respectively; p < 0.001). ABA showed an additional body weight loss (−9%) compared to RF (p < 0.001) reaching a body weight loss of −22% during the 2-week restricted feeding period (p < 0.001). Food intake was greatly reduced in RF (−38%) and ABA (−41%) compared to AL (p < 0.001). Interestingly, no difference in 1.5-h food intake microstructure was observed between RF and ABA (p > 0.05). Similarly, the daily physical activity was not different between AC and ABA (p > 0.05). The investigation of Fos expression in the brain showed neuronal activation in several brain nuclei such as the supraoptic nucleus, arcuate nucleus, locus coeruleus and nucleus of the solitary tract of ABA compared to AL rats. In conclusion, ABA combining physical activity and restricted feeding likely represents a suited animal model for AN to study pathophysiological alterations and pharmacological treatment options. Nonetheless, cautious interpretation of the data is necessary since rats do not voluntarily reduce their body weight as observed in human AN.

show abstract

Characteristics of Disorder‐Related Autobiographical Memory in Acute Anorexia Nervosa Patients

Abstract: This study detects disorder-related autobiographical memory alterations in AN, which are intensified in response to symptom-related cues. The findings are discussed with regard to their maladaptive function in emotion regulation.

Cited by 26 publications

References 60 publications

Social Difficulties As Risk and Maintaining Factors in Anorexia Nervosa: A Mixed-Method Investigation

Social Difficulties As Risk and Maintaining Factors in Anorexia Nervosa: A Mixed-Method Investigation

Meaningful Memory in Acute Anorexia Nervosa Patients—Comparing Recall, Learning, and Recognition of Semantically Related and Semantically Unrelated Word Stimuli

Activity-Based Anorexia Reduces Body Weight without Inducing a Separate Food Intake Microstructure or Activity Phenotype in Female Rats—Mediation via an Activation of Distinct Brain Nuclei

Contact Info

Product

Resources

About