Characteristics of disrupted topological organization in white matter functional connectome in schizophrenia

Jiang, Yuchao; Yao, Dezhong; Zhou, Jingyu; Tan, Yue; Huang, Hong; Wang, Meilin; Chang, Xin; Duan, Mingjun; Luo, Cheng

doi:10.1017/s0033291720003141

Cited by 37 publications

(32 citation statements)

References 63 publications

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“…This evidence indicates that the fMRI BOLD signal is a novel perspective for investigating WM dysfunction in brain disorders such as mild cognitive impairment, epilepsy, Alzheimer's and Parkinson's diseases (Ji, et al, 2019;Jiang, et al, 2019b;Makedonov, et al, 2016). More recently, our study revealed disrupted functional synchronization between WM and grey matter networks in SZ (Jiang, et al, 2019a;Jiang, et al, 2020).…”

Section: Introductionsupporting

confidence: 53%

Function-structure Coupling: White matter fMRI hyper-activation associates with structural integrity reductions in schizophrenia

Jiang

Yao

et al. 2021

Preprint

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BackgroundWhite matter (WM) microstructure deficit may be an underlying factor in the brain dysconnectivity hypothesis of schizophrenia using diffusion tensor imaging (DTI). However, WM dysfunction is unclear in schizophrenia. This study aimed to investigate the association between structural deficits and functional disturbances in major WM tracts in schizophrenia.MethodsUsing functional magnetic resonance imaging (fMRI) and DTI, we developed the skeleton-based white matter functional analysis, which could achieve voxel-wise function–structure coupling by projecting the fMRI signals onto a skeleton in WM. We measured the fractional anisotropy (FA) and WM low-frequency oscillation activation and their couplings in ninety-three schizophrenia patients and 122 healthy controls (HCs). An independent open database (62 schizophrenia patients and 71 HCs) was used to test the reproducibility. Finally, associations between WM activations and five behaviour assessment categories (cognition, emotion, motor, personality and sensory) were examined.ResultsThis study revealed a reversed pattern of structure and function in frontotemporal tracts, as follows. (1) WM hyper-activation was associated with reduced FA in schizophrenia. (2) The function–structure association was positive in healthy controls but negative in schizophrenia patients. Furthermore, function–structure dissociation was exacerbated by long illness duration and severe negative symptoms. (3) WM activations were significantly related to cognition and emotion.ConclusionsThis study indicated function–structure dys-coupling, with higher functional activation and reduced structural integration in frontotemporal WM, which may reflect a potential mechanism in WM neuropathologic processing of schizophrenia.

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Section: Introductionsupporting

confidence: 53%

Function-structure Coupling: White matter fMRI hyper-activation associates with structural integrity reductions in schizophrenia

Jiang

Yao

et al. 2021

Preprint

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“…For this background, the degree analysis approach was used to investigate the pathophysiological mechanism of OCD from the FC alterations throughout the whole brain at rest in the present study. Previous studies have delineated the degree values from FC in schizophrenia [ 16 ] and Alzheimer's disease [ 17 ] to physical connectivity in patients with major depression [ 18 ], alcohol dependence [ 19 ], and schizophrenia [ 20 ]. In addition, increased degree values in the OFC and basal ganglia were found at rest in OCD [ 21 ], and changes in the degree of the right ventral frontal cortex were related to the alleviation of OCD symptoms.…”

Section: Introductionmentioning

confidence: 99%

Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder

Wang

et al. 2021

Neural Plasticity

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Background. Previous studies explored the whole-brain functional connectome using the degree approach in patients with obsessive-compulsive disorder (OCD). However, whether the altered degree values can be used to discriminate OCD from healthy controls (HCs) remains unclear. Methods. A total of 40 medication-free patients with OCD and 38 HCs underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Data were analyzed with the degree approach and a support vector machine (SVM) classifier. Results. Patients with OCD showed increased degree values in the left thalamus and left cerebellum Crus I and decreased degree values in the left dorsolateral prefrontal cortex, right precuneus, and left postcentral gyrus. SVM classification analysis indicated that the increased degree value in the left thalamus is a marker of OCD, with an acceptable accuracy of 88.46%, sensitivity of 87.50%, and specificity of 89.47%. Conclusion. Altered degree values within and outside the cortical-striatal-thalamic-cortical (CSTC) circuit may cocontribute to the pathophysiology of OCD. Increased degree values of the left thalamus can be used as a future marker for OCD understanding-classification.

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“…This part of the scale is often used to evaluate the stereotyped thinking, abstract thinking, etc. [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Impairments in brain perfusion, executive control network, topological characteristics, and neurocognition in adult patients with asymptomatic Moyamoya disease

Liu

Wei

et al. 2021

BMC Neurosci

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Background Asymptomatic Moyamoya disease (MMD) impairs hemodynamic and cognitive function. The relationship between these changes, cerebral blood flow (CBF), and network connectivity remains largely unknown. The aim of this study was to increase understanding of the relationship between CBF, functional networks, and neurocognition in adults with asymptomatic MMD. We compared CBF and functional status in 26 patients with MMD and 20 healthy controls using arterial spin labeling and resting state functional magnetic resonance imaging sequences. At the same time, a detailed cognitive test was performed in 15 patients with no cerebral or lumen infarction who were selected by magnetic resonance imaging-T2 FLAIR screening. Results Compared to the controls, the patients showed varying degrees of decline in their computational ability (simple subtraction, p = 0.009; complex subtraction, p = 0.006) and short-term memory (p = 0.042). The asymptomatic MMD group also showed decreased CBF in the left anterior central and left inferior frontal gyri of the island flap with multiple node abnormalities in the brain network and reduced network connectivity. There was a significant association of these changes with cognitive decline in the MMD group. Conclusions In patients with asymptomatic MMD, disturbance of CBF and impaired brain network connections may be important causes of cognitive decline and appear before clinical symptoms. Clinical trial registration-URL: http://www.chictr.org.cn Unique identifier: ChiCTR1900023610

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Characteristics of disrupted topological organization in white matter functional connectome in schizophrenia

Cited by 37 publications

References 63 publications

Function-structure Coupling: White matter fMRI hyper-activation associates with structural integrity reductions in schizophrenia

Function-structure Coupling: White matter fMRI hyper-activation associates with structural integrity reductions in schizophrenia

Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder

Impairments in brain perfusion, executive control network, topological characteristics, and neurocognition in adult patients with asymptomatic Moyamoya disease

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