Characteristics of Eugenol Products and in Vitro Release in Gel Base With Hydroxypropyl Methylcellulose (Hpmc) Variant as Gelling Agent

Rohmani, Sholichah; Yugatama, Adi; Wijayanti, Isti; Ermawati, Dian Eka; Artanti, Anif Nur; Kundarto, Wisnu; Zulpadly, M Fiqri

doi:10.22159/ijap.2021v13i6.42351

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Additionally, the gels were exposed to soybean casein-digested media for fungus at a temperature of 25 °C for a duration of 14 days. Following the incubation time, the proliferation of bacteria or fungi is seen (El-Say et al, 2016;Rohmani et al, 2021).…”

Section: Sterility Testmentioning

confidence: 99%

Development and Evaluation of Implanted In Situ Gel Formulation for Treatment of Osteoarthritis

Anasuya,

Srinivasa Rao,

Abhijeet

et al. 2024

Intern. J. Zool. Invest.

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The primary aim of the present study was to develop and assess a topical gel containing Diacerein-loaded transferosomes in order to address the limitations of oral administration of Diacerein in the treatment of Osteoarthritis. Osteoarthritis, the prevailing kind of arthritis, is the primary cause of disability and lacks effective symptomatic treatment options. Diacerein hinders the interaction with the function of interleukin 1-β and is beneficial in the palliative management of osteoarthritis, while it also induces diarrhoea when taken orally. Diacerein is rapidly eliminated from the body since it has a short half-life. Therefore, a sustained release formulation is necessary for long-term administration in order to enhance patient adherence. Osteoarthritis, unlike other joint disorders, specifically affects one or a few joints. This characteristic allows for targeted Intra-articular treatment, minimising the potential for systemic adverse effects. An enhanced delivery mechanism is urgently required to enhance bioavailability and mitigate drug-related toxicity and the inefficacy of anti-inflammatory medicines. An investigation was conducted to assess the efficacy of Diacerein in situ gel as a potential treatment for Osteoarthritis. The formulation consists of poloxamer 407 as the primary polymer, hydroxypropyl methylcellulose K4, and carbopol 934 as the copolymer. It is manufactured using the conventional cold technique and is distinguished by multiple properties. All characterizations yielded satisfactory outcomes. The drug release is conducted in vitro using a phosphate buffer solution with a pH of 7.4, which indicates a regulated release of the medication.

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Section: Sterility Testmentioning

confidence: 99%

Development and Evaluation of Implanted In Situ Gel Formulation for Treatment of Osteoarthritis

Anasuya,

Srinivasa Rao,

Abhijeet

et al. 2024

Intern. J. Zool. Invest.

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Anti-Inflammatory Activity and Irritation Test of Topical Dosage Forms of Clove Leaf Essential Oil (Syzygium Aromaticum) in Animals

JANUARTI,

LATIFAH,

FIRMANSYAH

et al. 2024

Int J App Pharm

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Objective: Clove leaves (Syzygium aromaticum) contain compounds, namely eugenol, alpha-humulene, beta-caryophyllene, and caryophyllene oxide with the main compound eugenol, which has anti-inflammatory activity. One of dosage form to treat inflammation on the skin is a topical dosage form because it is quickly absorbed into the skin. This study aimed to formulate Clove Leaf Essential Oil (CLEO) and evaluate the physical properties, anti-inflammatory activity, and irritation effects of various topical dosage forms (emulgel, balsam, massage oil, and stick balm). Methods: Research design was a pre-posttest control group. Essential oils were obtained using the steam distillation method. The four different concentrations of CLEO topical dosage form (emulgel, balsam, massage oil, and stick balm) are 5% and 10%. Then, test are conducted on the physical qualities (organoleptic, pH, displaced volume, spreadability, sticking power, moisture content and viscosity). Anti-inflammatory activity using the carrageenan-induced paw edema method in Wistar rats was divided into four groups are dosage form CLEO concentrations of 5% and 10%, base preparation, and positive control. Anti-inflammatory activity results were analyzed with Post-hoc statistical analysis with a 95% confidence level. The irritation method was used to measure the Primary Irritation Index (PII) followed procedure by Indonesian Food and Drug Authority about Guidelines for in vivo Preclinical Toxicity Testing. Results: All these dosage forms met the physical requirements. Anti-inflammatory activity will rise as result of increasing the CLEO content in the formulae. All these dosage forms did not cause irritation in animal. Conclusion: Among the four formulations, balsam CLEO 10% showed maximum inhibitory oedema (94.05%), at the end of 360 min followed by balsam CLEO 5%, emulgel CLEO 10%, stick balm CLEO 10% and massage oil CLEO 10%.

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Characteristics of Eugenol Products and in Vitro Release in Gel Base With Hydroxypropyl Methylcellulose (Hpmc) Variant as Gelling Agent

Cited by 2 publications

References 3 publications

Development and Evaluation of Implanted In Situ Gel Formulation for Treatment of Osteoarthritis

Development and Evaluation of Implanted In Situ Gel Formulation for Treatment of Osteoarthritis

Anti-Inflammatory Activity and Irritation Test of Topical Dosage Forms of Clove Leaf Essential Oil (Syzygium Aromaticum) in Animals

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