Characteristics of gastric cancer around the world

López, María José; Carbajal, Junior; Alfaro, Alejandro; Saravia, Luis G.; Zanabria, Eusebio D.; Araujo, Jhajaira M.; Quispe, Lidia; Vizcarra, Karla A.; Buleje, José L.; Choo, Christina Eunbee; Sarmiento, Marisol; Pinto, Joseph A.; Fajardo, Williams

doi:10.1016/j.critrevonc.2022.103841

Cited by 111 publications

(52 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastric cancer, commonly known as stomach cancer, poses a significant global health challenge and ranks among the leading causes of cancer‐related mortality worldwide 1–3 . Despite advancements in medical technologies and therapeutic strategies, the prognosis for gastric cancer remains unfavourable, particularly in advanced stages of the disease 4–6 .…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Differential genetic mutations and immune cell infiltration in high‐ and low‐risk STAD: Implications for prognosis and immunotherapy efficacy

Deng,

Sun,

et al. 2024

J Cellular Molecular Medi

View full text Add to dashboard Cite

This study investigates genetic mutations and immune cell dynamics in stomach adenocarcinoma (STAD), focusing on identifying prognostic markers and therapeutic targets. Analysis of TCGA‐STAD samples revealed C > A as the most common single nucleotide variant (SNV) in both high and low‐risk groups. Key mutated driver genes included TTN, TP53 and MUC16, with frame‐shift mutations more prevalent in the low‐risk group and missense mutations in the high‐risk group. Interaction analysis of hub genes such as C1QA and CD68 showed significant correlations, impacting immune cell infiltration patterns. Using ssGSEA, we found higher immune cell infiltration (B cells, CD4+ T cells, CD8+ T cells, DC cells, NK cells) in the high‐risk group, correlated with increased risk scores. xCell algorithm results indicated distinct immune infiltration levels between the groups. The study's risk scoring model proved effective in prognosis prediction and immunotherapy efficacy assessment. Key molecules like CD28, CD27 and SLAMF7 correlated significantly with risk scores, suggesting potential targets for high‐risk STAD patients. Drug sensitivity analysis showed a negative correlation between risk scores and sensitivity to certain treatments, indicating potential therapeutic options for high‐risk STAD patients. We also validated the carcinogenic role of RPL14 in gastric cancer through phenotypic experiments, demonstrating its influence on cancer cell proliferation, invasion and migration. Overall, this research provides crucial insights into the genetic and immune aspects of STAD, highlighting the importance of a risk scoring model for personalized treatment strategies and clinical decision‐making in gastric cancer management.

show abstract

Section: Introductionmentioning

confidence: 99%

RETRACTED: Differential genetic mutations and immune cell infiltration in high‐ and low‐risk STAD: Implications for prognosis and immunotherapy efficacy

Deng,

Sun,

et al. 2024

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Stomach (0.8 million, 7.7%), female breast (0.7 million, 6.9%), prostate (0.4 million, 3.8%), and corpus uteri (0.1 million, 1.0%) cancer contribute a significant number of cancer-related deaths [ 3 ]. Although stomach cancer is a highly heterogeneous disease, it is considered the third cause of death among oncological patients [ 3 , 6 ]. Additionally, an estimate suggests one in six cancer deaths in women was due to breast cancer [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Amaryllidaceae Plants against Cancer Cells: Biotechnological, In Vitro, and In Silico Approaches

et al. 2023

View full text Add to dashboard Cite

Cancer is a major cause of death and an impediment to increasing life expectancy worldwide. With the aim of finding new molecules for chemotherapeutic treatment of epidemiological relevance, ten alkaloid fractions from Amaryllidaceae species were tested against six cancer cell lines (AGS, BT-549, HEC-1B, MCF-7, MDA-MB 231, and PC3) with HaCat as a control cell line. Some species determined as critically endangered with minimal availability were propagated using in vitro plant tissue culture techniques. Molecular docking studies were carried out to illustrate binding orientations of the 30 Amaryllidaceae alkaloids identified in the active site of some molecular targets involved with anti-cancer activity for potential anti-cancer drugs. In gastric cancer cell line AGS, the best results (lower cell viability percentages) were obtained for Crinum jagus (48.06 ± 3.35%) and Eucharis bonplandii (45.79 ± 3.05%) at 30 µg/mL. The research focused on evaluating the identified alkaloids on the Bcl-2 protein family (Mcl-1 and Bcl-xL) and HK2, where the in vitro, in silico and statistical results suggest that powelline and buphanidrine alkaloids could present cytotoxic activity. Finally, combining experimental and theoretical assays allowed us to identify and characterize potentially useful alkaloids for cancer treatment.

show abstract

“…Gastric cancer is the fifth most common cancer in the globe, with more than 1.08 million new cases diagnosed annually. It is also the fourth greatest cause of cancer‐related fatalities worldwide, accounting for 770 thousand deaths each year 151 . The search for innovative and effective treatments for gastric cancer is particularly critical.…”

Section: Pyroptosis and Inflammasomes In Cancermentioning

confidence: 99%

Pyroptosis and inflammasomes in cancer and inflammation

Wang,

Hua,

Bao

et al. 2023

MedComm

View full text Add to dashboard Cite

Nonprogrammed cell death (NPCD) and programmed cell death (PCD) are two types of cell death. Cell death is significantly linked to tumor development, medication resistance, cancer recurrence, and metastatic dissemination. Therefore, a comprehensive understanding of cell death is essential for the treatment of cancer. Pyroptosis is a kind of PCD distinct from autophagy and apoptosis in terms of the structure and function of cells. The defining features of pyroptosis include the release of an inflammatory cascade reaction and the expulsion of lysosomes, inflammatory mediators, and other cellular substances from within the cell. Additionally, it displays variations in osmotic pressure both within and outside the cell. Pyroptosis, as evidenced by a growing body of research, is critical for controlling the development of inflammatory diseases and cancer. In this paper, we reviewed the current level of knowledge on the mechanism of pyroptosis and inflammasomes and their connection to cancer and inflammatory diseases. This article presents a theoretical framework for investigating the potential of therapeutic targets in cancer and inflammatory diseases, overcoming medication resistance, establishing nanomedicines associated with pyroptosis, and developing risk prediction models in refractory cancer. Given the link between pyroptosis and the emergence of cancer and inflammatory diseases, pyroptosis‐targeted treatments may be a cutting‐edge treatment strategy.

show abstract

Characteristics of gastric cancer around the world

Cited by 111 publications

References 50 publications

RETRACTED: Differential genetic mutations and immune cell infiltration in high‐ and low‐risk STAD: Implications for prognosis and immunotherapy efficacy

RETRACTED: Differential genetic mutations and immune cell infiltration in high‐ and low‐risk STAD: Implications for prognosis and immunotherapy efficacy

Cytotoxic Activity of Amaryllidaceae Plants against Cancer Cells: Biotechnological, In Vitro, and In Silico Approaches

Pyroptosis and inflammasomes in cancer and inflammation

Contact Info

Product

Resources

About