Characteristics of gastric cancer detected within 1 year after successful eradication of <i>Helicobacter pylori</i>

Abstract

Gastric cancers are sometimes diagnosed in patients who have successfully undergone Helicobacter pylori (H. pylori) eradication. We analyzed the clinicopathological features of gastric cancers detected after eradication to clarify their characteristics. We reviewed 31 patients with 34 cases of gastric cancer detected after successful H. pylori eradication. Clinicopathological characteristics analyzed included interval since eradication, interval since last endoscopy, tumor size, and depth of invasion. Patients were classified into two groups: early detection (<1 year since eradication) and delayed detection (≥1 year since eradication). The interval since last endoscopy was significantly shorter in the early detection group than in the delayed detection group. However, gastric cancers were significantly larger and more invasive in the early detection group than in the delayed detection group. In conclusion, diligent endoscopy is necessary during the first year after successful H. pylori eradication. (The University Hospital Medical Information Network clinical trial registration number is UMIN000018541.)

Eradication of <b><i>Helicobacter pylori</i></b> Induces Immediate Regressive Changes in Early Gastric Adenocarcinomas

“…No significant differences were noted in the histopathological types of the eradicated and non-eradicated cancers, and this result was consistent with previous reports [11, 14, 22, 25, 26]. Additionally, independently of the eradication status, a gastrointestinal phenotype was observed more often than the gastric, intestinal, and null phenotypes in our analysis.…”

Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance

“…Surgery and endoscopic resection at an early stage is still the only chance for cure . Although it has been reported that H. pylori eradication therapy reduces the incidence of gastric cancer and is widely conducted to prevent gastric carcinogenesis, gastric cancers are still diagnosed in patients who received successful eradication therapy . Thus, endoscopic surveillance of gastric cancers after H. pylori eradication is expected to be a beneficial approach for detection.…”

“…7,8 Although it has been reported that H. pylori eradication therapy reduces the incidence of gastric cancer and is widely conducted to prevent gastric carcinogenesis, gastric cancers are still diagnosed in patients who received successful eradication therapy. [9][10][11][12][13] Thus, endoscopic surveillance of gastric cancers after H. pylori eradication is expected to be a beneficial approach for detection. The endoscopic and histological features of gastric cancers after eradication have been investigated vigorously.…”

Prevention of gastric cancer by Helicobacter pylori eradication: A review from Japan

“…It has also been reported that the incidence of primary EGC increases 5 years after H pylori has been eradicated . Moreover, this new form has been observed not only in MGC but also in primary EGC after H pylori eradication (Figure ) …”

“…21 Moreover, this new form has been observed not only in MGC but also in primary EGC after H pylori eradication (Figure 4). [22][23][24][25] Because this form of EGC is different from that of gastric cancer that occurs in the conventional H pylori-infected stomach, there is a possibility that this form of cancer may be misdiagnosed or diagnosed after it has progressed to a later stage. In addition, the belief among endoscopists that gastric cancer is less likely to develop after H pylori eradication may lead to a detection bias.…”