“…In Jewish and non-Jewish Caucasian populations, the N370S (cDNA 1226G) GC mutation is the most prevalent (Amaral et al, 1993;Horowitz and Zimran, 1994;Lacerda et al, 1994a), causing synthesis of a catalytically abnormal enzyme (Grace et al, 1990;Ohashi et al, 1991;van Weely et al, 1993). This mutation has so far not been encountered in the Japanese population (Ida et al, 1995). The L444P (cDNA 1448C) GC mutation is relatively frequent in the Jewish and non-Jewish Caucasian populations and in Japanese populations Ida et al, 1995) and leads to synthesis of glucocerebrosidase, which is rapidly degraded (Grace et al, 1991;Ohashi et al, 1991;Grace et al, 1994).…”