Imprint Cytology of Gaucher’s Disease Presenting as a Splenic Mass

Kobayashi, Tadao K.; Tamagaki, Toshiyuki; Yoneyama, Chihiro; Watanabe, Shinsuke; Sugihara, Hiroyuki; Ida, Hiroyuki

doi:10.1159/000331630

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…Zeppa et al, 23 Kobayashi et al 35 In our study, only 2 cases (5.9%) showed reactive picture. This means that there were no likely possibility of neoplastic lesion or storage disorder.…”

Section: 32supporting

confidence: 39%

Role of aspiration cytology in splenic lesions

2016

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INTRODUCTIONThe FNAC has become quite popular diagnostic modality now days. Splenic fine needle aspiration cytology (FNAC) as a diagnostic procedure has been used since beginning of last century and was first reported in 1916. 1 Although many authors from different centers have highlighted its utility for diagnosing splenic pathology, it is used routinely in very few cases. It has the reputation of being a dangerous intervention and the specimen obtained is usually thought to be unduly difficult to assess, but these prejudicial ideas are fundamentally wrong.2-8 FNAC is a safe, easy, simple, reproducible and rapid diagnostic procedure and has distinct advantage over open true cut or core biopsy. As it requires no special instrument and incur no significant trauma and cost to the patient Although radiological modalities like ultrasound, CT scan, or MRI usually narrow down the differential diagnosis but rarely provide a definitive picture and tissue sample in form of an aspirate or a biopsy is required to clinch a specific diagnosis.9-15 In these circumstances, FNAC remains the first mainstay diagnostic investigation. Splenic pathology can be localised or secondary to systemic involvement in various diseases. The indications of splenic FNAC [3][4][5]8,16 are non- ABSTRACTBackground: Splenic fine needle aspiration cytology (FNAC) as a diagnostic procedure has been used since beginning of last century and was first reported in 1916. The objective of the study was to evaluate the diagnostic role of aspiration cytology in splenic lesions. Methods: In our retrospective study Fine needle aspiration cytology (FNAC) of spleen was done in a total 34 cases, out of which 28 cases were aspirated under ultrasonological guidance and 6 cases were aspirated blindly. There were 23 male and 11 female patients and the age range of the patients was from 2 to 69 years with 8 patients from paediatric group. Before commencing the procedure all the necessary precautions and investigations including coagulation profile were done. Results: Out of 34 FNAC cases, 5 were bloody aspirate while 2 cases showed normal splenic aspirate. In 27 cases definite diagnostic opinion was possible. Amongst non-neoplastic group maximum patients (8 cases) were showing features of extra medullary hematopoeisis followed by 4 cases of tuberculosis, then 3 cases each of kala azar and storage disorder and 2 cases showed granulomas. In the neoplastic group, we had 2 cases of non-Hodgkins lymphoma, one case of Hodgkin lympoma with 2 cases of hairy cell leukemia and one case of histiocytosis. No major difference in the cellularity noticed when the aspiration done blindly or under ultrasound guidance No procedural complications were seen in our study. Conclusion:Hence when done with full precautions FNAC spleen is a safe, cheap, rapid and highly diagnostic procedure as a primary investigation.

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“…Zeppa et al, 23 Kobayashi et al 35 In our study, only 2 cases (5.9%) showed reactive picture. This means that there were no likely possibility of neoplastic lesion or storage disorder.…”

Section: 32supporting

confidence: 39%

Role of aspiration cytology in splenic lesions

2016

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“…The Gaucher cells were large and their cytoplasm had a characteristic reticulated or wrinkled tissue paper appearance in air-dried Diff-Quik preparations, as has been described in previous reports. 14,22 Primary benign neoplasms of the spleen can be potential pitfalls in the analysis of cytologic material due to the rarity of these lesions. Patients with primary splenic neoplasm are often asymptomatic and lesions are detected incidentally in imaging studies unrelated to splenic disease.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with primary splenic neoplasm are often asymptomatic and lesions are detected incidentally in imaging studies unrelated to splenic disease. 22 Splenic lymphangioma is a rare, benign tumor that occurs more commonly in children. Although it has been reported in prior studies of the spleen, there are no known reports of its cytologic findings.…”

Section: Discussionmentioning

confidence: 99%

“…24 Splenic hamartoma and littoral cell hemangioma 12,25 are two other rare entities that can pose considerable diagnostic problems. Both entities can present as multiple nodules in the spleen, 22,25 therefore mimicking metastatic disease. 26 Careful evaluation of the aspirated material including cell block preparation with immunohis- tochemistry can guide the pathologist to the correct diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic pitfalls in fine needle aspiration biopsy of the spleen

Friedlander

Wei

Iyengar

et al. 2008

Diagnostic Cytopathology

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Fine needle aspiration (FNA) of the spleen is rarely performed, due to fear of procedure complications. The objective of this study is to review the cytologic diagnoses of aspiration biopsy of the spleen performed in a cancer center. Archival material (9-year period) was reviewed and correlated with histologic and ancillary test results, when available.Forty-one splenic FNA specimens were identified. There were no reported procedure complications. Nineteen cases were diagnosed as malignant. Of these, 11 were lymphomas. Nineteen cases were diagnosed as benign. There was one false-negative case and four false-positive cases. Primary splenic neoplasms were rare and misinterpreted as malignant. It is important to be familiar with the normal cytology of this uncommonly aspirated organ in order to successfully identify neoplastic and malignant processes. The use of ancillary studies is important in the definitive classification of benign and malignant splenic lesions.

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“…Coating thickness method. Suppose the specific surface area of material is a definite value, the average coating thickness is proportional to the coating quality, calculate coating thickness of the metal content of the fiber by measuring the quality of silver before and after coating, and which indicated the metal content of the fiber [4,9]. In the fiber coating process, the coated film is not uniform because fibers are subject to some erosion in coating process, which is the need to improve coatings fastness.…”

Section: The Testing and Characterization Methods Of Contents Of Meta...mentioning

confidence: 99%

Metal Content Determination of Metallized Fiber by Density Testing

Zheng

2010

AMR

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Metal content of metallized fiber can be determined by density testing and calculating. The weight of plated metal’s percentage of metallized fiber can be derived form measuring the weight of metallized fiber, and using the density formula and the law of conservation of mass with knowing the density of plated metal and the basic fiber. The characterization and measurement of the metal content of the metallized fiber at home and abroad is compared, the principle of the determination method by density testing is analyzed, the principle of the determination method by density testing is analyzed, and the specific operation is discussed while the silver content determination of silver-plated fiber is as an example, which provides a simple and convenient means for the determination of metal content of the metallized fiber..

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Imprint Cytology of Gaucher’s Disease Presenting as a Splenic Mass

Cited by 4 publications

References 7 publications

Role of aspiration cytology in splenic lesions

Role of aspiration cytology in splenic lesions

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen

Metal Content Determination of Metallized Fiber by Density Testing

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