Characteristics of higher-order aberrations and anterior segment tomography in patients with pathologic myopia

Kasahara, Kaori; Maeda, Naoyuki; Fujikado, Takashi; Tomita, Makoto; Moriyama, Muka; Fuchihata, Mutsumi; Ohno‐Matsui, Kyoko

doi:10.1007/s10792-016-0356-7

Cited by 21 publications

(19 citation statements)

References 33 publications

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“…Some other studies were only concerned with the evaluation of myopia-related HOAs. Kasahara et al [33] estimated HOAs in patients with pathological myopia and found that highly myopic eyes had more HOAs than emmetropic eyes because of the increased internal aberrations. Karimian et al [34] also concluded that primary horizontal trefoil, spherical aberrations, and primary vertical coma were the predominant HOAs in eyes with myopic astigmatism.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Corneal Higher-Order Aberrations by Scheimpflug–Placido Topography in Patients with Different Refractive Errors: A Retrospective Observational Study

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Mostafa

Elhawary

et al. 2019

Journal of Ophthalmology

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Purpose. To report the characteristics of anterior and posterior corneal high-order aberrations in patients with different refractive errors. Setting. This study was conducted at Sohag Refractive Center, Sohag, Egypt. Design. This is a retrospective observational study. Methods. This study evaluated 750 patients (750 eyes) who were seeking refractive surgery. The eyes were stratified into five groups (150 eyes/group) based on refractive error: mild-to-moderate myopia, high myopia, hyperopia, simple myopic astigmatism, and simple hypermetropic astigmatism. All patients were subjected to comprehensive ophthalmological examination including corneal topography and corneal aberrometry using the Scheimpflug–Placido topography (Sirius, CSO, Italy). Results. Coma aberration was statistically significant when compared in all five groups (P=0.01). It was highest in the hypermetropia group (0.26 ± 0.12 μm) but lower in the moderate myopia, high myopia, myopic astigmatism, and hypermetropic astigmatism groups. Spherical aberration was lowest in the hypermetropia group and significantly different from that in the other groups. Trefoil was statistically insignificant when all groups were compared (P=0.062) but was highest in the myopic astigmatism group (0.24 ± 0.25 μm). Total RMS peaked in the hypermetropia group (0.99 ± 0.70). Conclusions. In normal corneas and regular refractive errors, the cornea-induced high-order aberration was minimal, and all types of refractive errors were associated with certain types of high-order aberrations, with a significant increase in spherical aberration in the hypermetropia group.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Corneal Higher-Order Aberrations by Scheimpflug–Placido Topography in Patients with Different Refractive Errors: A Retrospective Observational Study

Anbar

Mostafa

Elhawary

et al. 2019

Journal of Ophthalmology

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“…The induction of HOAs can cause significant night vision problems including glare, haze, and halos. HOAs are related to the scotopic pupil size [20], the treatment optic zone [21], and the preoperative refraction [22]. Spherical aberration is usually accepted as a single aberration that is most closely affected by the degree of myopic correction performed.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of LASEK for High Myopia Correction between the Triple-A Profile and the Zyoptix Tissue Saving Profile

Shi

Sun

et al. 2019

Journal of Ophthalmology

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Purpose. To compare the effects of correcting high myopia using the MEL®90 Triple-A profile LASEK at a 500 Hz pulse rate (Triple-A group) versus the Zyoptix tissue-saving ablations of Technolas 217z laser platform at 100 Hz (TS group). Methods. This retrospective study included 50 eyes in the Triple-A group and 42 eyes in the TS group with manifest refraction spherical equivalent (MRSE) of −6 diopters (D) to −10 D. We compared uncorrected distance visual acuity, MRSE, corrected distance visual acuity, and postoperative complications at 1 month, 3 months, and 6 months. Results. At 6 months after refractive surgery, the efficacy index of Triple-A group was significantly higher than that of the TS group (1.03 ± 0.12 vs 1.00 ± 0.11, P=0.04). The MRSE postoperatively in the Triple-A group was significantly lower than that in the TS group (0.25 ± 0.18 vs 0.38 ± 0.23, P<0.01). The safety indices in the two groups were almost the same after 6 months of surgery (1.03 ± 0.07 vs 1.04 ± 0.11, P=0.63). The proportion of eyes which achieved ±0.13 D was significantly higher in the Triple-A group than that in the TS group at 1 month (80% vs 59.5%, P=0.03), 3 months (82% vs 61.9%, P=0.03) and 6 months (84% vs 64.3%, P=0.03). The changes in refraction 6 months after surgery comparing with 1 month after surgery were 0.12 ± 0.10 D in the Triple-A group and 0.13 ± 0.08 D in the TS group (P=0.56). All (100%) of the patients in the Triple-A group and 50% of the patients in the TS group had a UDVA of 20/16 at 6 months after surgery (P<0.01). The induced spherical aberrations and total HOAs in the Triple-A group were significantly lower than those in the TS group (0.17 ± 0.02 μm vs 0.23 ± 0.02 μm, P<0.01; 0.20 ± 0.04 μm vs 0.39 ± 0.03 μm, P<0.01) at 6 months after surgery. The mean reduced corneal thickness was 113.06 ± 10.5 μm in the Triple-A profile group and 121.43 ± 23.46 μm in the TS group (P=0.02). No patient in either group had haze and high intraocular pressure 6 months after surgery. Conclusion. For treatment of high-myopia patients, the Triple-A profile was more effective, predictable, and accurate than the Zyoptix tissue-saving profile. Meanwhile, the Triple-A profile had less induced spherical aberrations, total HOAs, and cornea ablation depth than the Zyoptix tissue-saving profile. Patients in the Triple-A group with 500 Hz pulse rate treatment achieved superior results. The two surgical procedures were equivalent in terms of safety and stability.

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“…However, many of these reported associations have been inconsistent, as they have been confounded by varying patient selection, variability in definitions of myopia and the use of different imaging techniques 59. Although most of the refractive error associated with myopia comes from the axial length, it is increasingly recognised that changes of the anterior segment in high myopia lead to significant optical and higher order aberrations 60. A potentially interesting aspect is the study of biomechanical changes associated with corneal thickness in high myopia, which may affect the evaluation of intraocular pressure61 and diagnosis of glaucoma—elaborated further later in this review 62.…”

Section: Introductionmentioning

confidence: 99%

Imaging in myopia: potential biomarkers, current challenges and future developments

et al. 2019

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Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal neovascularisation detection, while multimodal imaging is important for monitoring treatment response. However, imaging the eye with high myopia accurately has its challenges and limitations, which are important for clinicians to understand in order to choose the best imaging modality and interpret the images accurately. In this review, we present the current imaging modalities available from the anterior to posterior segment of the myopic eye, including the optic nerve. We summarise the clinical indications, image interpretation and future developments that may overcome current technological limitations. We also discuss potential biomarkers for myopic progression or development of complications, including basement membrane defects, and choroidal atrophy or choroidal thickness measurements. Finally, we present future developments in the field of myopia imaging, such as photoacoustic imaging and corneal or scleral biomechanics, which may lead to innovative treatment modalities for myopia.

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Characteristics of higher-order aberrations and anterior segment tomography in patients with pathologic myopia

Abstract: Highly myopic eyes had higher-order aberrations than emmetropic eyes because of the increasing internal aberrations.

Cited by 21 publications

References 33 publications

Evaluation of Corneal Higher-Order Aberrations by Scheimpflug–Placido Topography in Patients with Different Refractive Errors: A Retrospective Observational Study

Evaluation of Corneal Higher-Order Aberrations by Scheimpflug–Placido Topography in Patients with Different Refractive Errors: A Retrospective Observational Study

Clinical Evaluation of LASEK for High Myopia Correction between the Triple-A Profile and the Zyoptix Tissue Saving Profile

Imaging in myopia: potential biomarkers, current challenges and future developments

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