Characteristics of Lymphoma in Patients with Inflammatory Bowel Disease: A Systematic Review

Müller, Marie; Broséus, Julien; Feugier, Pierre; Thiéblemont, Catherine; Beaugerie, Laurent; Danese, Silvio; Arnone, Djésia; Ndiaye, Ndeye Coumba; Kökten, Tunay; Houlgatte, Rémi; Peyrin–Biroulet, Laurent

doi:10.1093/ecco-jcc/jjaa193

Cited by 17 publications

(13 citation statements)

References 58 publications

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“…Knowledge about lymphoma in patients with IBD is limited to epidemiological data and the description of risk factors [131]. However, clinicians should bear in mind that Crohn's disease may be complicated by neoplasia such as adenocarcinomas or lymphomas, especially if the disease duration is long and the patient is under immunosuppressive therapy [132]. The prognosis for lymphomas occurring in IBD appears to be good and what is expected, irrespective of the exposure to biologics and/or immunosuppressants [133].…”

Section: Neoplasticmentioning

confidence: 99%

Small and Large Intestine (I): Malabsorption of Nutrients

2021

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Numerous disorders can alter the physiological mechanisms that guarantee proper digestion and absorption of nutrients (macro- and micronutrients), leading to a wide variety of symptoms and nutritional consequences. Malabsorption can be caused by many diseases of the small intestine, as well as by diseases of the pancreas, liver, biliary tract, and stomach. This article provides an overview of pathophysiologic mechanisms that lead to symptoms or complications of maldigestion (defined as the defective intraluminal hydrolysis of nutrients) or malabsorption (defined as defective mucosal absorption), as well as its clinical consequences, including both gastrointestinal symptoms and extraintestinal manifestations and/or laboratory abnormalities. The normal uptake of nutrients, vitamins, and minerals by the gastrointestinal tract (GI) requires several steps, each of which can be compromised in disease. This article will first describe the mechanisms that lead to poor assimilation of nutrients, and secondly discuss the symptoms and nutritional consequences of each specific disorder. The clinician must be aware that many malabsorptive disorders are manifested by subtle disorders, even without gastrointestinal symptoms (for example, anemia, osteoporosis, or infertility in celiac disease), so the index of suspicion must be high to recognize the underlying diseases in time.

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Section: Neoplasticmentioning

confidence: 99%

Small and Large Intestine (I): Malabsorption of Nutrients

2021

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“…A recent systematic review reported that NHL was the most common histological type (83.9%) in the IBD patients. Furthermore, EBV positive status was observed in a large part of lymphoma patients with IBD (44-75%) (Muller et al, 2020). Patients with IBD who receive thiopurines are likely to develop a subset of lymphoma similar to EBV-related malignant lymphoma that develops after organ transplantation.…”

Section: Involvement Of Long-term Thiopurines and Onset Of Lymphoproliferative Disorders (Lpds)mentioning

confidence: 99%

Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases

et al. 2021

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Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) of unknown etiology, characterized by repeated relapse and remission. The efficacy of thiopurine in IBD was first reported in the late 1960s. Thiopurines are used to alleviate the symptoms of IBD, especially UC. These drugs have a steroid-sparing potential and are widely used for the purpose of maintaining long-term remission in steroid-dependent cases. Therefore, thiopurines tend to be used long-term, but adverse events that accompany long-term use, such as lymphoproliferative disorders, must be monitored with care. In contrast, thiopurine plays a critical role in controlling the immunogenicity of biologics. Furthermore, although thiopurine is an old drug, new findings, including the prediction of serious adverse events such as severe alopecia and acute advanced leukopenia, by nudix hydrolase 15 gene polymorphism analysis, as well as the possibility of appropriate drug monitoring by detailed analysis of 6-thioguanine nucleotides have been clarified. However, the consequences of thiopurine withdrawal have not been determined and further studies, including randomized controlled trials, are necessary to answer the clinical question regarding the scenarios in which thiopurine withdrawal is possible.

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“…However, it is important to point out that direct and indirect mechanisms of virus-driven carcinogenesis are not mutually exclusive and some tissues may be equally dependent on both mechanisms for oncogenic transformation, such as the liver and stomach [13]. While current evidence strongly suggests a role of certain viruses, e.g., Epstein-Barr virus (EBV) in the pathogenesis of lymphoma in IBD patients [34] or human papillomavirus (HPV) in cervical cancer [35], the role of these and other viruses in gastrointestinal cancer remains less clear.…”

Section: Virusesmentioning

confidence: 99%

Viruses in Cancers of the Digestive System: Active Contributors or Idle Bystanders?

Marônek

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Monteleone

et al. 2020

IJMS

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The human virome, which is a collection of all the viruses that are present in the human body, is increasingly being recognized as an essential part of the human microbiota. The human gastrointestinal tract and related organs (e.g., liver, pancreas, and gallbladder)—composing the gastrointestinal (or digestive) system—contain a huge number of viral particles which contribute to maintaining tissue homeostasis and keeping our body healthy. However, perturbations of the virome steady-state may, both directly and indirectly, ignite/sustain oncogenic mechanisms contributing to the initiation of a dysplastic process and/or cancer progression. In this review, we summarize and discuss the available evidence on the association and role of viruses in the development of cancers of the digestive system.

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Characteristics of Lymphoma in Patients with Inflammatory Bowel Disease: A Systematic Review

Cited by 17 publications

References 58 publications

Small and Large Intestine (I): Malabsorption of Nutrients

Small and Large Intestine (I): Malabsorption of Nutrients

Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases

Viruses in Cancers of the Digestive System: Active Contributors or Idle Bystanders?

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