Characteristics of Mood Disorders in Japanese Patients with Medication-Overuse Headache

Kaji, Yoshiaki; Hirata, Koichi

doi:10.2169/internalmedicine.48.1884

Cited by 12 publications

(10 citation statements)

References 33 publications

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“…In this study, although the difference was not significant, we found that MOH patients who had MO as primary headaches were slightly more common than MO patients in the migraine group. Furthermore, the frequency of comorbidity with depression was higher in MOH patients than in migraine patients [3][4][5]. We also confirmed that the prevalence of depression was significantly higher in MOH patients than in migraine patients.…”

Section: Discussionsupporting

confidence: 81%

“…Although most patients return to the episodic migraine pattern after drug withdrawal, the complications of MOH markedly decrease the quality of life of patients [1]. Furthermore, in contrast to migraine patients, the percentage of comorbidity with depression in MOH patients is higher [3][4][5]. Therefore, it is important to prevent the complications of MOH in patients with migraines.…”

Section: Introductionmentioning

confidence: 99%

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A Cyclooxygenase 2 Gene Polymorphism is a Risk Factor for the Complication of Medication Overuse Headaches in Patients with Migraines

Ishii

Katoh²,

Kurihara³

et al. 2015

J Neurol Disord

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We determined whether cyclooxygenase-2 (COX-2) gene polymorphisms were involved in the aggravation of migraines due to the overuse of medication. Polymorphisms in the COX-2 (rs20417, rs689466) gene were examined. Forty-seven patients with migraine (6 males and 41 females; 5 with migraines with aura (MA), 36 with migraines without aura (MO), 6 with MA + MO; 1 with MA and 21 with MO; 36.4 ± 10.3 years) and 22 patients with medication overuse headache (MOH) (1 male and 21 females; 39.6 ± 9.9 years) who had migraines participated in this study. The genotypes of each polymorphism were analyzed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods. No significant differences were observed in the genotypic distributions of rs20417 (C/C + G/C vs. G/G, p=0.220) between migraine patients and MOH patients. The frequencies of the rs689466 G/G genotype were significantly higher in patients with MOH than in patients with migraines (G/G vs. A/A+A/G, p=0.008). Furthermore, the frequencies of the rs689466 G/G genotype were significantly higher in patients with MOH who had migraines without aura (MO) than in patients with MO (G/G vs. A/A+A/G, p=0.001). The results of this study showed that the COX-2 polymorphism (rs689466) was independently related with the complication of MOH in patients with MO.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

A Cyclooxygenase 2 Gene Polymorphism is a Risk Factor for the Complication of Medication Overuse Headaches in Patients with Migraines

Ishii

Katoh²,

Kurihara³

et al. 2015

J Neurol Disord

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“…In addition, the polymorphisms of SOD (rs4880) [9] and GPX1 (rs1050450) [10] genes have also been implicated in major depression. Previous studies revealed a higher percentage of comorbidity with depression in MOH patients than in migraine patients [11,12] . We also reported that the experience of depression is significantly more frequent in MOH patients than in migraine patients [15] .…”

Section: Discussionmentioning

confidence: 80%

“…In addition, SOD (rs4880) [9] and glutathione peroxidase-1 (GPX1, rs1050450) [10] polymorphisms have also been implicated in major depression which is recognized as a risk factor for the development of MOH in migraine patients [11,12] . However, to the best of our knowledge, there have been no studies on the relationship between antioxidant enzyme gene polymorphisms and MOH.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Enzyme Gene Polymorphisms in Japanese Migraine Patients with Medication Overuse Headache

Ishii

Hirano

Katoh

2015

International Journal of Neurology Research

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“…However, the complication of MOH markedly decreases the quality of life of these patients [1]. In addition, the incidence of comorbidity with depression is higher in MOH patients than in migraine patients [3,5]. Therefore, the aggravation of migraines due to medication overuse needs to be prevented.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between CGRP-related gene polymorphisms and medication overuse headache in migraine patients

Ishii¹,

Katoh²,

Kurihara³

et al. 2015

Integr Mol Med

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We investigated whether calcitonin gene-related peptide (CGRP)-related gene polymorphisms are involved in the aggravation of migraines due to medication overuse. In total, 47 migraine patients (6 males and 41 females; 36.4 ± 10.3 years) and 22 medication overuse headache (MOH) patients (1 male and 21 females; 39.6 ± 9.9 years) who had migraine participated in this study. Calcitonin gene-related polypeptide-alpha (CALCA, α-CGRP, Insertion/Deletion rs1553005, rs145837941) and CGRP receptor (receptor activity-modifying protein 1: RAMP1, rs3754701, rs7590387) were analyzed by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP) methods. No significant differences were observed in the genotype distributions of CALCA and RAMP1 between migraine patients and MOH patients. The results of this study showed no association between CGRP-related gene polymorphisms and the complication of MOH in migraine patients.

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Characteristics of Mood Disorders in Japanese Patients with Medication-Overuse Headache

Abstract: Objective

Cited by 12 publications

References 33 publications

A Cyclooxygenase 2 Gene Polymorphism is a Risk Factor for the Complication of Medication Overuse Headaches in Patients with Migraines

A Cyclooxygenase 2 Gene Polymorphism is a Risk Factor for the Complication of Medication Overuse Headaches in Patients with Migraines

Antioxidant Enzyme Gene Polymorphisms in Japanese Migraine Patients with Medication Overuse Headache

Lack of association between CGRP-related gene polymorphisms and medication overuse headache in migraine patients

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