Characteristics of Multidrug Resistant Tuberculosis in Minia, Egypt

doi:10.37506/mlu.v20i1.399

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…No significant difference was found between the two groups in terms of the gender of participants ( p = 0.685 ). However, the male gender was higher in both groups representeing (80%) of DR-TB patients and 66% of DS-TB patients, which aligns with the results reported in several other studies [ 3 , 20 , 21 ]. This matches the epidemiological pattern of tuberculosis as males have more hours of outdoor exposure and usually have more risk factors, such as smoking and alcohol intake.…”

Section: Discussionsupporting

confidence: 91%

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The association of IL-17A rs2275913 single nucleotide polymorphism with anti-tuberculous drug resistance in patients with pulmonary tuberculosis

Elmadbouly,

Abdul-Mohymen,

Eltrawy

et al. 2023

Journal of Genetic Engineering and Biotechnology

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Background Drug-resistant Tuberculosis (DR-TB) is a global health burden with high morbidity and mortality in developing countries including Egypt. The susceptibility to infection with DR-TB strains may be genetically determined. Several interleukin gene polymorphisms were investigated as risk factors for tuberculosis infection but focusing on their association with DR-TB was limited. Therefore, the objective of this study is to assess the association of IL 17 − 197 G > A (rs2275913) single nucleotide polymorphism (SNP) with susceptibility to DR-TB strains in comparison to drug-sensitive tuberculosis (DS-TB) strains in Egyptian patients with pulmonary TB. This cross-sectional study was conducted on 80 patients with DR-TB strains and 80 with DS-TB strains as a control group. Both age and sex were comparable among the study’s groups. IL-17 − 197 G > A (rs2275913) SNP was genotyped by real-time PCR, and IL-17 serum concentration was measured by enzyme-linked immunosorbent assay (ELISA). Results The GA and AA genotype frequencies of IL 17 − 197 G > A (rs2275913) SNP were significantly higher in patients with DR-TB strains than those with DS-TB strains (p < 0.001). The frequency of the A allele was significantly (p < 0.001) higher in patients with DR-TB group (32.5%) compared to the control group (13.8%). Substantial higher serum levels of IL-17 were detected in the DR-TB group with significant association with AA and AG genotypes. Conclusion Polymorphism in IL-17 -197 G > A (rs2275913) resulted in higher serum levels of IL-17 and Egyptian patients with such polymorphism are three times at risk of infection with DR-TB strains than patients with wild type.

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Section: Discussionsupporting

confidence: 91%

“…In our study, there was also an insignificant difference between both groups regarding age ( p = 0.414 ). However, the mean age for TB in both groups was similarly reported in other studies [ 20 – 22 ]. These findings were attributed to the high mobility and social interaction during this reproductive age [ 23 ].…”

Section: Discussionsupporting

confidence: 84%

The association of IL-17A rs2275913 single nucleotide polymorphism with anti-tuberculous drug resistance in patients with pulmonary tuberculosis

Elmadbouly,

Abdul-Mohymen,

Eltrawy

et al. 2023

Journal of Genetic Engineering and Biotechnology

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“…Considering the ratio of infections among males vs females, one study reported that the split between males and females with multi-drug resistant tuberculosis was 70.4% and 29.6% respectively [ 201 ], In a study conducted in patients with resistant tuberculosis in Ghana, the ratio of males and females was 69.6% and 30.4% respectively [ 202 ], whilst in another study conducted in Egypt, the ratio of males and females was reported as 67.5% and 32.5%, respectively [ 203 ]. Moreover, in a similar research work conducted in Ethiopia 65.3% male and 34.7% female has multi drug resistant TB [ 204 ].…”

Section: Discussionmentioning

confidence: 99%

Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis

Salari,

Kanjoori,

Hosseinian-Far

et al. 2023

Infect Dis Poverty

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Background Tuberculosis is a bacterial infectious disease, which affects different parts of a human body, mainly lungs and can lead to the patient’s death. The aim of this study is to investigate the global prevalence of drug-resistant tuberculosis using a systematic review and meta-analysis. Methods In this study, the PubMed, Scopus, Web of Science, Embase, ScienceDirect and Google Scholar repositories were systematically searched to find studies reporting the global prevalence of drug-resistant tuberculosis. The search did not entail a lower time limit, and articles published up until August 2022 were considered. Random effects model was used to perform the analysis. The heterogeneity of the studies was examined with the I2 test. Data analysis was conducted within the Comprehensive Meta-Analysis software. Results In the review of 148 studies with a sample size of 318,430 people, the I2 index showed high heterogeneity (I2 = 99.6), and accordingly random effects method was used to analyze the results. Publication bias was also examined using the Begg and Mazumdar correlation test which indicated the existence of publication bias in the studies (P = 0.008). According to our meta-analysis, the global pooled prevalence of multi-drug resistant TB is 11.6% (95% CI: 9.1–14.5%). Conclusions The global prevalence of drug-resistant tuberculosis was found to be very high, thus health authorities should consider ways to control and manage the disease to prevent a wider spread of tuberculosis and potentially subsequent deaths.

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Characteristics of Multidrug Resistant Tuberculosis in Minia, Egypt

Cited by 2 publications

References 8 publications

The association of IL-17A rs2275913 single nucleotide polymorphism with anti-tuberculous drug resistance in patients with pulmonary tuberculosis

The association of IL-17A rs2275913 single nucleotide polymorphism with anti-tuberculous drug resistance in patients with pulmonary tuberculosis

Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis

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