“…1,2 Moreover, the middle-aged general working population report local and referred pain at the neck-shoulder angles with a symmetrical left-right distribution. 3,4 However, most previous experimental studies related to the mechanisms of muscle pain have employed single or repeated injections of hypertonic saline 5 rather than bilateral injections, which might not exactly mirror the cutaneous and muscular sensitivity changes in chronic trapezius myalgia with bilateral pain. Bilateral injections possess, to some extent, the characteristics of multiple injections or electrical stimulations that induce central hyperexcitability, 6 spatial, 7,8 and temporal summation of pain intensity.…”