Characteristics of PEGylated Polydiacetylene Liposome and its Inclusion Complex Formation with α-Cyclodextrin

Abstract

Diacetylene lipid monomers possess the capability to self-assemble into vesicles via polymerization under ultraviolet irradiation, resulting in the formation of polydiacetylene (PDA) liposomes. Exposure of the polymerized vesicles to external stimuli is known to induce a unique blue-to-red color transition. The cyclic oligosaccharide α-cyclodextrin known for its use in many applications, such as drug delivery, purification, and stimulus sensing, is able to form an inclusion complex with poly(ethylene glycol) (PEG) in aqueous solution. In this study, we prepared polymeric liposomes with PEG (PEG-PDA) with the aim of improving the stability of the vesicles and colorimetric response toward α-cyclodextrin. We demonstrated that PEG-PDA liposome displays unique characteristics compared with native PDA liposome and it also shows apparent chromic properties of the inclusion complex formation with α-cyclodextrin.

Colorimetric detection of influenza A (H1N1) virus by a peptide-functionalized polydiacetylene (PEP-PDA) nanosensor

“…Consequently, studies of PDA materials are expanding, particularly for biosensing applications. 24,25,27,29,31,37 Here, we developed a peptide-functionalized polydiacetylene (PEP-PDA) nanosensor enabling detection of pandemic H1N1 virus (pH1N1) with the naked eye. As illustrated in Fig.…”

“…Based on the unique chromic characteristics of the PDA nanosensors, we attempted to detect inuenza A (H1N1) virus with the naked eye. 24,25,27,29,31,37 The PDA nanosensors were modied with a peptide (PEP) capable of specic binding with H1N1 virus, as conrmed in our previous report. 1 The colorimetric response of the PEP-PDA nanosensors in the presence of pH1N1 was conrmed by an obvious blue-to-red color change and a shi in the absorption spectrum.…”

“…18,19 Among the many colorimetric detection approaches, polydiacetylene (PDA) has been extensively studied as a colorimetric sensing material, owing to its unique chromatic properties. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] The self-assembly of diacetylene monomers into spherical PDA vesicles with a conjugated backbone of alternating double and triple bonds (ene-yene chain) occurs upon ultraviolet (UV) irradiation. Unperturbed PDA vesicles typically exhibit an intense blue color because of electronic absorption via a p-p* transition of the electrons in the conjugated backbone.…”

Colorimetric Transition of Polydiacetylene/Cyclodextrin Supramolecular Assemblies and Implications as Colorimetric Sensors for Food Phenolic Antioxidants

“…After standing for 1 h at room T, an increase in turbidity of the suspensions was observed related to the formation of the PDA‐CD complex. [ 57 ] For UV–vis analysis, the suspensions were centrifugated for 15 min at 3000 rpm.…”