Characteristics of physical prefrailty among Japanese healthy older adults

Matsushita, Eiji; Okada, K.; Ito, Yoshiaki; Satake, Shosuke; Shiraishi, Nariaki; Hirose, Takahisa; Kuzuya, Masafumi

doi:10.1111/ggi.12935

Cited by 30 publications

(20 citation statements)

References 18 publications

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“…The Japanese version of the Cardiovascular Health Study (J‐CHS) is the most widely used model for evaluations of frailty To date, various simplifications and modifications of this model have been developed . We used the J‐CHS, which was validated for the evaluation of frailty . The J‐CHS includes the following items: (i) Have you lost ≥2 kg during the past 6 months?…”

Section: Methodsmentioning

confidence: 99%

Comparison of three frailty models and a sarcopenia model in elderly patients with chronic obstructive pulmonary disease

Hirai

Tanaka

Homma

et al. 2019

Geriatrics Gerontology Int

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Aim: Frailty and sarcopenia affect the prognosis and quality of life of patients with chronic obstructive pulmonary disease (COPD). However, it remains uncertain which model is the most suitable for evaluating vulnerability in patients with COPD. We evaluated the validity of three frailty modelsthe Kihon Checklist (KCL), the Japanese version of the Cardiovascular Health Study and the Study of Osteoporotic Fracturesand one sarcopenia model for older patients with COPD.Methods: This cross-sectional study included 201 older (aged ≥65 years) outpatients with COPD. We used three frailty models and one sarcopenia model to identify their correlation with various indices that can evaluate the status of COPD and determine the most ideal model for evaluating vulnerability in patients with COPD.Results: The highest prevalence of frailty (38%) and lowest prevalence of robustness (26%) were observed using the KCL. Although all models reflected the characteristics of COPD, the KCL yielded the strongest correlations with clinically important physical, psychological and prognostic indices. The KCL yielded statistically significant differences in almost all indices among the three intergroup comparisons (robust, pre-frailty and frailty). The KCL was superior in extracting mood disorders to the other models.Conclusion: Although all investigated models were useful, the KCL was the most suitable for evaluating the frailty status and might enable interventions in patients with COPD.

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Section: Methodsmentioning

confidence: 99%

Comparison of three frailty models and a sarcopenia model in elderly patients with chronic obstructive pulmonary disease

Hirai

Tanaka

Homma

et al. 2019

Geriatrics Gerontology Int

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“…In a systematic review of risk factors for malnutrition in older adults, frailty and constipation were significant risk factors for malnutrition ( 19 ). Matsushita et al reported that, in the logistic regression model for the prevalence of prefrailty, chronic constipation was a signiﬁcant and independent determinant, and they suggested that autonomic failure is associated with prefrailty among older individuals ( 20 ). According to a study that investigated the frailty status of inpatients >65 years old in Shanghai, constipation is a risk factor of frailty, and it was recommended to include frailty as an indicator in the existing assessment to rate the disease and develop a disease observation plan ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

The Association between Frailty and Abdominal Symptoms: A Hospital-based Cross-sectional Study

et al. 2020

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Objective The association between frailty and abdominal symptoms has not been evaluated. Methods We conducted a hospital-based, retrospective cross-sectional study of consecutive outpatients ≥65 years old at the Department of Gastroenterology, Juntendo Tokyo Koto Geriatric Medical Center from 2017 to 2019. Patients were included in the study if all of the following information was available from their medical records: patient's profile, the evaluation of osteoporosis, sarcopenia, frailty, nutritional status, findings of upper gastrointestinal endoscopy, and questionnaire results for abdominal symptoms [Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG) and Constipation Scoring System (CSS)]. We divided the subjects into frailty and non-frailty groups and investigated the risk factors for frailty. Results Of the 313 eligible study subjects [134 men (42.8%) and 179 women (57.2%); mean age, 75.7±6.0 years; mean body mass index, 22.8±3.6 kg/m 2 ], frailty was noted in 71 cases (22.7%). In a univariate analysis, an older age (p<0.001), female gender (p=0.010), successful eradication of Helicobacter pylori (p=0.049), proton pump inhibitor (PPI) use (p<0.001), laxative/prokinetics use (p=0.008), sarcopenia (p<0.001), osteoporosis (p<0.001), hypozincemia (p=0.002), hypoalbuminemia (p<0.001), low lymphocytes (p=0.004), a high CONUT score (p<0.001), a high FSSG score (p=0.001), and a high CSS score (p<0.001) were significantly associated with frailty. A multivariate logistic regression analysis showed that an older age [odds ratio (OR) 1.16; 95% confidence interval (CI) 1.08-1.24, p<0.001], PPI use (OR 2.42; 95% CI 1.18-4.98, p=0.016), sarcopenia (OR 7.35; 95% CI 3.30-16.40, p<0.001), hypozincemia (OR 0.96; 95% CI 0.92-0.99, p=0.027), a high FSSG score (OR 1.08; 95% CI 1.01-1.16, p=0.021), and a high CSS score (OR 1.13; 95% CI 1.03-1.23, p=0.007) were significantly associated with frailty. Conclusion Advanced age, PPI user, sarcopenia, hypozincemia, a high FSSG score, and high CSS score are associated with frailty.

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“…All participants provided written consent for inclusion in the study. Other cross-sectional and longitudinal results have been published elsewhere [ 24 , 25 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

Sex-Specific Association between Social Frailty and Diet Quality, Diet Quantity, and Nutrition in Community-Dwelling Elderly

et al. 2020

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The effects of social frailty on diet and nutrition are under-investigated. Our study aimed to assess the association between social frailty and diet quality, diet quantity, and nutrition over a 3-year period in community-dwelling older Japanese adults. This prospective cohort study recruited individuals aged ≥60 years from a community college and followed up 666 participants annually. Social frailty was determined using a 4-item questionnaire. Diet quantity (energy and macronutrient intake) and diet quality (dietary diversity score and Diet Quality Index-International) were assessed using a food frequency questionnaire. Nutrition was evaluated using the Mini-Nutritional Assessment (MNA). Out of the 666 participants (56.5% women), 250 (37.5%) were categorized as having social prefrailty or frailty. Regarding diet quantity, energy intake (β = −1.59kcal/kg/day, p < 0.01) and nutrient intake (protein intake, β = −0.08g/kg/day; fat intake, β = −0.06g/kg/day; carbohydrate intake, β = −0.18g/kg/day; fiber intake, β = −0.01g/kg/day; all p < 0.05) were lower in men with social prefrailty or frailty than in men with social robustness. Dietary diversity score (β = −0.25, p = 0.01) and MNA score (β = −0.32, p = 0.04) decreased in men with social prefrailty or frailty. However, these associations were not observed in women. Social frailty is associated with lower dietary intake, poor diet quality, and poor nutrition among community-dwelling older men. Future studies are required to determine the benefits of sex-specific interventions targeting social frailty on nutritional outcomes.

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Characteristics of physical prefrailty among Japanese healthy older adults

Abstract: These results suggest that the appearance of autonomic failure, oral malfunction and some psychological factors in relation to depressed mood, but not anthropometric measurements, are characteristic of prefrailty. Geriatr Gerontol Int 2017; 17: 1568-1574.

Cited by 30 publications

References 18 publications

Comparison of three frailty models and a sarcopenia model in elderly patients with chronic obstructive pulmonary disease

Comparison of three frailty models and a sarcopenia model in elderly patients with chronic obstructive pulmonary disease

The Association between Frailty and Abdominal Symptoms: A Hospital-based Cross-sectional Study

Sex-Specific Association between Social Frailty and Diet Quality, Diet Quantity, and Nutrition in Community-Dwelling Elderly

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