Characteristics of reovirus type 1 from the respiratory tract of pigs in Japan.

Hirahara, Tadashi; Yasuhara, Hisao; Matsui, Osamu; Kodama, Kazuo; Nakai, M.; Sasaki, Norimasa

doi:10.1292/jvms1939.50.353

Cited by 12 publications

(12 citation statements)

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“…Similar trends in reovirus infections containing multiple serotypes have been previously reported in healthy dogs [ 28 , 29 , 30 ], cattle [ 31 ], swine [ 32 ] and humans [ 9 , 33 , 34 ]. Infections with multiple MRVs represent the basis for the genesis of new reassortant strains in permissive hosts, and insectivorous bats may play an important role in this genesis.…”

Section: Discussionsupporting

confidence: 79%

Detection and Characterization of a Novel Reassortant Mammalian Orthoreovirus in Bats in Europe

Lelli

Moreno

Steyer

et al. 2015

Viruses

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A renewed interest in mammalian orthoreoviruses (MRVs) has emerged since new viruses related to bat MRV type 3, detected in Europe, were identified in humans and pigs with gastroenteritis. This study reports the isolation and characterization of a novel reassortant MRV from the lesser horseshoe bat (Rhinolophus hipposideros). The isolate, here designated BatMRV1-IT2011, was first identified by electron microscopy and confirmed using PCR and virus-neutralization tests. The full genome sequence was obtained by next-generation sequencing. Molecular and antigenic characterizations revealed that BatMRV1-IT2011 belonged to serotype 1, which had not previously been identified in bats. Phylogenetic and recombination detection program analyses suggested that BatMRV1-IT2011 was a reassortant strain containing an S1 genome segment similar to those of MRV T1/bovine/Maryland/Clone23/59 and C/bovine/Indiana/MRV00304/2014, while other segments were more similar to MRVs of different hosts, origins and serotypes. The presence of neutralizing antibodies against MRVs has also been investigated in animals (dogs, pigs, bovines and horses). Preliminary results suggested that MRVs are widespread in animals and that infections containing multiple serotypes, including MRVs of serotype 1 with an S1 gene similar to BatMRV1-IT2011, are common. This paper extends the current knowledge of MRVs and stresses the importance to continue and improve MRV surveillance in bats and other mammals through the development and standardization of specific diagnostic tools.

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Section: Discussionsupporting

confidence: 79%

Detection and Characterization of a Novel Reassortant Mammalian Orthoreovirus in Bats in Europe

Lelli

Moreno

Steyer

et al. 2015

Viruses

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“…Hence, reovirus infection of more than one serotype can still occur depending on exposure. Similar trends of reovirus infection of multiple serotypes have been previously reported in healthy dogs [6, 17, 19], cattle [24], swine [7] and humans [20, 21, 31]. This finding has provided important information, suggesting that neutralizing antibodies against reovirus T1L and T2A will not affect the usage of reovirus T3D as therapy in canine cancers.…”

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confidence: 79%

Seroepidemiology of Reovirus in Healthy Dogs in Six Prefectures in Japan

Hwang

Mochizuki

Maeda

et al. 2014

The Journal of Veterinary Medical Science

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Reovirus infection is common in mammals. However, seroepidemiological data of reovirus neutralizing antibodies are limited in dogs. In this study, sera of 65 healthy dogs from six prefectures across Japan were tested for neutralizing antibodies against reovirus serotype 1 strain Lang (T1L), serotype 2 strain Amy (T2A) and serotype 3 strain Dearing (T3D) using plaque reduction neutralization test (PRNT). Seropositivity against reovirus T1L, T2A and T3D was 53.85%, 33.85% and 46.15%, respectively. Distribution of reovirus seropositive samples displayed no distinguishable geographical pattern. However, reovirus seropositivity increased with age and in dogs housed outdoor. Co-infection of multiple reovirus serotypes in dogs was also detected. These data will provide valuable insights towards the usage of reovirus in oncolytic virotherapy in canine cancers.

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“…Strains from human (32 human isolates) were isolated from the feces of healthy children (0 to 5 years old) and patients, who were suspected of having various virus infections (0 to 9 years old), in Toyama and Aichi Prefectures from 1973 to 1989. One strain from pig (1 pig isolate) was isolated from a nasal secretion of a 3-month-old pig in a farm in Niigata Prefecture in 1984 (7). One strain from oyster (1 oyster Preparation of reovirus RNA.…”

Section: Methodsmentioning

confidence: 99%

Ecological Studies on Reovirus Pollution of Rivers in Toyama Prefecture. II. Molecular Epidemiological Study of Reoviruses Isolated from River Water

Matsuura

Ishikura

Nakayama

et al. 1993

Microbiology and Immunology

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In order to clarify the source of reovirus pollution in river water, comparative surveys have been carried out between reovirus isolates from river water and those from sewage, human or animal, by making use of the analysis of genomic RNA-migration pattern of reovirus in polyacrylamide gel electrophoresis (electropherotype). The strains of reovirus serotype 1 and 2 isolated from river water were classified into 3 and 9 electropherotypes, respectively, and 8 out of these 12 types were also found among strains isolated from sewage or human. When the monthly distribution of the river isolates classified by electropherotypes was compared with that of the sewage isolates, there were cases in which strains of the same electropherotype were simultaneously isolated from both sources. The electropherotypes of 3 isolates from pig and field rodents were different from those of the other isolates. The electropherotype of an oyster isolate coincided with that of some of the isolates from humans and river water. These results indicate that the major sources of reoviruses polluting river water may be the human excretion.

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Characteristics of reovirus type 1 from the respiratory tract of pigs in Japan.

Cited by 12 publications

References 0 publications

Detection and Characterization of a Novel Reassortant Mammalian Orthoreovirus in Bats in Europe

Detection and Characterization of a Novel Reassortant Mammalian Orthoreovirus in Bats in Europe

Seroepidemiology of Reovirus in Healthy Dogs in Six Prefectures in Japan

Ecological Studies on Reovirus Pollution of Rivers in Toyama Prefecture. II. Molecular Epidemiological Study of Reoviruses Isolated from River Water

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