As a kind of low-frequency vehicle interior noise, tire acoustic cavity resonance noise plays an important role, since the other noise (e.g., engine noise, wind noise and friction noise) has been largely suppressed. For the suspension system, wheels stand first in the propagation path of this energy. Therefore, it is of great significance to study the influence of wheel design on the transmission characteristics of this vibration energy. However, currently the related research has not received enough attention. In this paper, two sizes of aluminum alloy wheel finite element models are constructed, and their modal characteristics are analyzed and verified by experimental tests simultaneously. A mathematically fitting sound pressure load model arising from the tire acoustic cavity resonance acting on the rim is first put forward. Then, the power flow method is applied to investigate the resonance energy distribution and transmission characteristics in the wheels. The structure intensity distribution and energy transmission efficiency can be described and analyzed clearly. Furthermore, the effects of material structure damping and the wheel spoke number on the energy transmission are also discussed.