Characteristics of syphilitic uveitis in northern China

Zhang, Xiao Min; Du, Qian; Ma, Feifei; Lu, Yinglong; Wang, Meiyan; Li, Xiaorong

doi:10.1186/s12886-017-0491-6

Cited by 17 publications

(13 citation statements)

References 28 publications

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“…2 This resurgence in syphilis cases in the United States corresponds with recent reports of ocular syphilis in nearly all regions of the globe, including the United Kingdom, Australia, South Africa, France, and China. 1,[3][4][5][6][7][8] Ocular syphilis classically presents as uveitis in secondary or tertiary syphilis and has been shown to affect all structures of the eye. 9 Although the timing of syphilis progression varies, a recent study has recorded a median time to ocular symptom development of 11 months following infection.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of a Case Series of Ocular Syphilis With 3 Cases Requiring Multiple Vitrectomies After Late Diagnosis

Nagarajan

Mundae

Tran

et al. 2020

Journal of VitreoRetinal Diseases

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Purpose: This work describes the characteristics and unique features of ocular syphilis. Methods: Ten serologically proven cases of ocular syphilis were retrospectively analyzed. Results: Eighteen eyes of 10 patients were affected. Nine of 10 patients were male and the mean age was 58 years (range, 36-81 years). HIV antibody testing was positive in 3 patients (30%). Five cases were first diagnosed by an ophthalmologist. One patient presented with a syphilitic rash. The most common ocular findings were panuveitis (n = 6) and cystoid macular edema (n = 4). Ocular involvement was unilateral in 2 cases and bilateral in 8. Best-corrected visual acuity improved in 13 of 18 eyes (72%) after treatment. Three cases developed recurrent retinal detachments that required repair with silicone oil. Conclusions: Most cases were HIV negative. Syphilitic uveitis can be the initial presentation of syphilis without classic systemic manifestation. Ophthalmologists play an important role in the diagnosis and treatment of syphilis.

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Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of a Case Series of Ocular Syphilis With 3 Cases Requiring Multiple Vitrectomies After Late Diagnosis

Nagarajan

Mundae

Tran

et al. 2020

Journal of VitreoRetinal Diseases

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“…To our knowledge, limited data is present in the literature about how often the ophthalmologist is the first one to make a diagnosis in described clinical entities. A recent study by Zhang et al [70] found that in all patients evaluated for uveitis in the 85.7% of cases the diagnosis of syphilis was made by the ophthalmologist, while in the remaining cases a previous diagnosis was made.…”

Section: Resultsmentioning

confidence: 99%

The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging

Pirani

Pelliccioni

Turris

et al. 2019

JCM

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Background: Syphilis, tuberculosis and toxoplasmosis are major infectious diseases worldwide; all of them are multisystem pathologies and share a possible ocular involvement. In this context, a fundamental help for the definitive diagnosis is provided by the ophthalmologist, through clinical evaluation and with the aid of a multimodal imaging examination. Methods: We hereby describe selected cases who came to our attention and were visited in our eye clinic. In all clinics, the use of retinal and optic disc multimodal imaging during ophthalmological evaluation allowed to make a diagnosis of an infectious disease. Results: In our tertiary referral center more than 60 patients with syphilis, tuberculosis and toxoplasmosis have been evaluated in the last two years: In 60% of cases the ophthalmological evaluation was secondary to a previous diagnosis of an infectious disease, while in the remaining cases the ophthalmologist, with the help of a multimodal imaging examination and clinical evaluation, represented the physician who leads to the diagnosis. Conclusion: Our results confirm how in these life-threatening pathologies a prompt diagnosis is mandatory and may benefit from a multidisciplinary and multimodal imaging approach, especially during ophthalmological evaluation.

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“…However, hypopyon is not an uncommon finding in luetic uveitis, with a prevalence of 6% of involved eyes in some recent series. 6 Previous studies by Davis et al have described distinctive clinical patterns of posterior segment involvement for syphilitic uveitis, including the presence of small, creamy white superficial retinal precipitates that may migrate over areas of retinitis. 7 It is possible that our patient may have had a more severe presentation of syphilitic uveitis due to his untreated HIV infection.…”

Section: Discussionmentioning

confidence: 98%