Characteristics of the dopamine receptors in the rabbit isolated splenic artyery

Hilditch, A.; Drew, G. M.

doi:10.1016/0014-2999(81)90566-5

Cited by 49 publications

(18 citation statements)

References 13 publications

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“…It is unlikely that prejunctional inhibition of noradrenaline release plays any role in the cerebrovascular vasodilatation observed in the present study, as there is no evidence that the resting tone of pial arterioles in the present conditions has any sympathetic component (see also the lack pf efficacy of phentolamine in the present study in altering arteriolar calibre) (Kuschinsky & Wahl, 1975). A second population of dopamine receptors is present in vascular smooth muscle in a number of vascular beds (for example, renal, coronary, femoral, mesenteric and splenic arteries), and after blockade of the contractile receptor mechanisms (most commonly with phenoxybenzamine) the actions of dopamine and dopamine receptor agonists cause relaxation of these peripheral arteries (Goldberg & Toda, 1975;Goldberg et al, 1978;Hilditch & Drew, 1981;Toda, 1983). The cerebrovascular dilatation mediated via dopamine receptor activation, noted in the present in situ study and in previous in vitro studies (Toda, 1976;Edvinsson et al, 1978;Oudart et al, 1981;Forster et al, 1983), are comparable, at least in general terms, with these peripheral dopamine receptors mediating vascular smooth muscle relaxation.…”

Section: Administration Of Drugsmentioning

confidence: 67%

Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists

Edvinsson

McCulloch

Sharkey

1985

British J Pharmacology

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1 The vasomotor responses of individual cerebral pial arterioles on the convexity of the cerebral cortex to subarachnoid perivascular micro-injections ofdopamine and the putative dopamine receptor agonists, apomorphine, SKF 38393 and LY 141865, have been examined in 38 anaesthetized cats. 2 The perivascular microapplication of dopamine (10-9-10-M) effected dose-dependent reductions in pial arteriolar calibre, with the maximum reductions in calibre (22 ± 2% from preinjection levels: mean ± s.e.) being observed at 10-3M. The cerebrovascular constriction produced by dopamine (10-sM) could be significantly attenuated by the concomitant perivascular administration of phentolamine (10-6M) or methysergide (10-6M). 3 The perivascular microapplication of apomorphine (10-8 10-4M) effected dose-dependent increases in arteriolar calibre, with the maximum increase (31 ± 6%) being observed with apomorphine (10-5M). 4 The perivascular administration of the putative dopamine Di-receptor agonist, SKF 38393 (10-9 1O-4 M) increased arteriolar calibre, with the maximum response (24 ± 3%) being observed with injection of 10-0M. The putative dopamine D2-receptor agonist, LY 141865, also increased cerebral arteriolar calibre, but only at high concentrations (maximum calibre increase 25 ± 6.1 with 10-4 M). 6 These results point to the presence on cat cerebral arterioles ofdopamine receptors (probably of DI subtype) mediating dilatation.

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Section: Administration Of Drugsmentioning

confidence: 67%

Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists

Edvinsson

McCulloch

Sharkey

1985

British J Pharmacology

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“…Papaverine (10*4 mol/1) was em ployed at the end of each experiment as a conventional test of vascular reactivity. Except for haloperidol which, as reported previously [Schmidt and hubs, 1980;Hilditch and Drew. 1981], produces by itself a slight decrease of perfusion pressure, the remaining compounds did not alter the base-line.…”

Section: Methodsmentioning

confidence: 80%

“…in itself, a problem; several sys tems have been proposed [Kebabian and Caine, 1979;Goldberg and Kohli, 1983], Another problem is the lack of drugs possess ing sufficient binding selectivity for each subtype of DA receptors. And lastly, there are technical problems with experimental prepa rations which are often complex, time-con suming, and expensive [Goldberg and Toda, 1975;Urquilla, 1976: Schmidt and Imbs, 1980: Hilditch and Drew, 1981. In this pa per, we present pharmacological data ob tained front the isolated and perfused renal artery of the rat, a preparation that is not so complex or expensive to use as some of those referred to above.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dopaminergic Agonists and Antagonists on the Partially Contracted, Isolated and Perfused Renal Artery of the Rat

Rodriguez-Mendez¹,

Feria²,

Boada³

1986

Pharmacology

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The effects of two dopamine agonists, dopamine itself and SKF 38393, alone and in the presence of several dopamine antagonists, have been studied in the partially contracted, isolated and perfused renal artery of the rat. In this preparation, earlier used by other authors in vascular pharmacological experiments, the dopaminergic agents produced clear vasodilator effects which were inhibited by all antagonists used. Due to its low cost and simplicity, such a preparation would be of practical value in testing dopaminergic drugs.

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“…Racemic sulpiride is an effective antagonist of dopamine-induced increases in renal and mesenteric blood flow in the anaesthetized dog (Clark & Menninger, 1980;Drew & Hilditch, 1980;Llenas et al, 1982), despite having a low affinity for DA1-dopamine receptors in vitro (Schmidt et al, 1981;Hilditch & Drew, 1981).…”

Section: Effect Of Sulpiride On Depressor Responses To Dopaminementioning

confidence: 99%

B‐HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors

Harland

1986

British J Pharmacology

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ITo investigate whether the hypotensive and bradycardiac effects of B-HT 958 (2-amino-6-(pchlorobenzyl)- 4H-5,6,7,8-tetrahydrothiazolo-(5,4-d) A combination of idazoxan 1000 pLg kg-' i.v. and sulpiride 300 Lg kg-' i.v. did not cause further significant inhibition of B-HT 958 hypotension and bradycardia compared with sulpiride 300 pg kg-' i.v. alone. This combination however had a significantly greater effect in inhibiting B-HT 958 hypotension than had idazoxan 1OOOpg kg-' alone, and almost completely blocked the B-HT 958-induced fall in plasma noradrenaline concentration. 6 These results suggest that in the anaesthetized rat the cardiovascular effects of B-HT 958 are due to stimulation of dopamine receptors, probably located within the central nervous system, and not to stimulation of peripheral prejunctional 2-adrenoceptors.

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Characteristics of the dopamine receptors in the rabbit isolated splenic artyery

Cited by 49 publications

References 13 publications

Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists

Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists

Effects of Dopaminergic Agonists and Antagonists on the Partially Contracted, Isolated and Perfused Renal Artery of the Rat

B‐HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors

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