1985
DOI: 10.1111/j.1476-5381.1985.tb08875.x
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Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists

Abstract: 1 The vasomotor responses of individual cerebral pial arterioles on the convexity of the cerebral cortex to subarachnoid perivascular micro-injections ofdopamine and the putative dopamine receptor agonists, apomorphine, SKF 38393 and LY 141865, have been examined in 38 anaesthetized cats. 2 The perivascular microapplication of dopamine (10-9-10-M) effected dose-dependent reductions in pial arteriolar calibre, with the maximum reductions in calibre (22 ± 2% from preinjection levels: mean ± s.e.) being observed … Show more

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Cited by 47 publications
(28 citation statements)
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“…The relationship between changes in rCBF and the angiogenesis induced by L-DOPA is presently unclear, but these phenomena are likely to share some common molecular and chemical determinants. Indeed, the D1 agonist SKF38393 causes vessel dilatation, whereas the D1 antagonist SCH23390 causes constriction of cerebral pial arterioles in vivo (Edvinsson et al, 1985). Furthermore, D1-specific agonists induce large increases in relative cerebral blood volume (rCBV) in regions of high DA receptor abundance, whereas the D1 receptor antagonist SCH23390 prevents this hemodynamic response (Choi et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…The relationship between changes in rCBF and the angiogenesis induced by L-DOPA is presently unclear, but these phenomena are likely to share some common molecular and chemical determinants. Indeed, the D1 agonist SKF38393 causes vessel dilatation, whereas the D1 antagonist SCH23390 causes constriction of cerebral pial arterioles in vivo (Edvinsson et al, 1985). Furthermore, D1-specific agonists induce large increases in relative cerebral blood volume (rCBV) in regions of high DA receptor abundance, whereas the D1 receptor antagonist SCH23390 prevents this hemodynamic response (Choi et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…Serial 8-µm thick sections were mounted on microscope slides and exposed for 12-18 h at 4°C to polyclonal anti-dopamine D1-D5 receptor antibodies [8,9] obtained from Calbiochem (San Diego, CA, U.S.A.) or Santa Cruz Biotechnology (Santa Cruz, CA, U.S.A.). The characteristics, working dilution and specificity of these antibodies as assessed in preliminary western blot experiments are summarized in Table 1.…”
Section: Methodsmentioning
confidence: 99%
“…In vivo investigations have demonstrated cerebral vasodilatation subsequent to dopamine administration [6] or after microapplication or perivascular microinjection of dopamine to pial arteries or subarachnoid membrane [6][7][8]. These effects were likely mediated through the interaction of dopamine with specific dopamine receptors since they were abolished by dopamine receptor antagonists [9].…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, the cat is one of the laboratory animals most studied with regard to its perivascular neurotransmitter levels (Duckles, 1981;Duckles & Buck, 1982;Duckles & Said, 1982;Marco et al, 1985), as well as the histochemical and immunoreactive distribution of perivascular fibres (Edvinsson et al, 1972;LiuChen et al, 1983;Gibbins et al, 1984;Saito et al, 1985). Furthermore, the vasomotor responses of cerebral arteries both in situ and in vitro have been much investigated in the cat (Wahl & Kuschinsky, 1976McCulloch & Edvinsson, 1980;Edvinsson et al, 1981;1985b;Edvinsson & Fredholm, 1983;Wahl et al, 1983;Medgett & Langer, 1983; Uski & Andersson, 1984).…”
Section: Introductionmentioning
confidence: 99%