Characteristics of the pain tolerance threshold induced by electrical stimulation of the alveolar ridge

Nakashima, Yoshio; Kimoto, Suguru; Ogawa, Takahiro; Furuse, Nobuhiko; Ono, Masanori; Kawai, Yasuhiko

doi:10.1002/cre2.14

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…Thus, through the excitation of the lingual nerve, the device is likely to (a) trigger the afferent large Aß fibers, which relay modalities of touch-pressure, vibration, and possibly proprioception and, thus, to evoke the salivary reflex engaging different types of salivary glands bilaterally, and to (b) stimulate directly the efferent secretomotor parasympathetic fibers to the ipsilateral submandibular and sublingual glands ( 12 ). The device is, however, unlikely (c) to stimulate the small somatic Aδ and C fibers for pain and temperature sensation as the output of the device (150µA) is well below the pain tolerance threshold in the alveolar ridge (1500µA), and (d) to stimulate the special afferent (taste) components as opposed to the taste response that can be evoked by the application of electrogustometry on the tongue taste buds ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Electrostimulation of the lingual nerve by an intraoral device may lead to salivary gland regeneration: A case series study

Wolff¹,

Koray²,

Campisi³

et al. 2018

Med Oral

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BackgroundSalivary gland function is controlled by the salivary reflex, whose efferent arm is composed by the parasympathetic and the sympathetic divisions of the autonomic nervous system. Parenchymal injury is the main salivary gland involvement of Sjögren’s syndrome and head and neck radiotherapy, but neural damage has been reported as well. Recently an intraoral device for electrostimulation of the lingual nerve in vicinity to the lower third molar has been introduced. At this point this nerve carries efferent fibers for the innervation of the submandibular, sublingual and several minor salivary glands and afferent fibers of the salivary reflex. Therefore, excitation of these fibers potentially leads to increased secretion of all salivary glands. Thus, the study objective was to assess whether comprehensive neural activation by electrostimulation of the lingual nerve carries the potential to induce the regeneration of damaged salivary glands.Material and MethodsThe device was tested on three patients with no collectable resting and stimulated secretion of saliva during a double blind, sham controlled period of two months and nine open-label months.ResultsAll three subjects developed the capacity to spit saliva, not only in direct response to the electrostimulation but also after free intervals without electrostimulation. In addition, their symptoms of dry mouth severity and frequency improved.ConclusionsThis recovery is probably due to the combined effect of increase in secretory functional gland mass and regain of nervous control of the secretory elements and blood vessels. Both are phenomena that would contribute to gland regeneration. Key words:Xerostomia, dry mouth, saliva, electrostimulation, regeneration.

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Section: Discussionmentioning

confidence: 99%

Electrostimulation of the lingual nerve by an intraoral device may lead to salivary gland regeneration: A case series study

Wolff¹,

Koray²,

Campisi³

et al. 2018

Med Oral

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“…The validity of the method is comparable to that of more popular standard sensory testing techniques, including thermal and vibration detection thresholds . Furthermore, we have developed electrical current stimulation for use in oral sensory measurements; use of this technique has shown that both CPT and PT can be useful in assessing changes in oral sensation in maxillary denture wearers …”

Section: Introductionmentioning

confidence: 89%

“…A single trained operator, who worked as an assistant for three years during previous trials, verbally explained the measurement process to each participant and exposed the participant to each of the three frequencies used to assess CPT prior to the actual CPT measurement. The actual test was conducted according to manufacturer's instructions: the electrical current was gradually increased from 0.01 mA until the subjects reported sensation for a given frequency.…”

Section: Methodsmentioning

confidence: 99%

Verification of the reliability of current perception threshold and pain threshold testing by application of an electrical current stimulus to mandibular mucosa in young adults

Furuse

Kimoto

Nakashima

et al. 2019

J of Oral Rehabilitation

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Usually, the dentist examines and diagnoses concerns based on a patient's complaint and addresses these concerns by adjusting the denture. However, the most frequently reported problems with dentures are related to new dentures, such as sore spots, painful gums and general discomfort, which might be differently perceived by each patient, 1 and thus, the perception of each patient might make denture management more difficult. 2 Therefore, if diagnosis and pain sensitivity prediction for the patient were standardised, it would help draft an appropriate treatment plan and to predicting the number of times that a denture needs to be adjusted. SummaryBackground: There is little evidence regarding the reliability of CPT and PT measurements to gauge mandibular perception. Thus, this study aimed to evaluate the testretest reliability of CPT and PT values obtained from the mandibular oral mucosa and to test the bilateral differences in CPT and PT values obtained from the mental foramen region and buccal shelf region by a single operator.Methods: CPT and PT values were obtained from the mental foramen and buccal shelf regions of 20 volunteers (10 males and 10 females; average age: 26.4 ± 2.6 years) by using the Neurometer CPT/C® device to deliver electrical stimulation.Results: Relative and absolute reliabilities were confirmed over two measurements of CPT and PT over a 7-to 10-day measurement interval. Intra-class correlation coefficients (ICCs) for CPT and PT table obtained from the mental foramen region were >0.8, while most ICC for the buccal shelf region were <0.8. Standard error of measurement, minimal detectable change and Bland-Altman analyses showed that the CPT and PT measurements had no systematic error and could serve as useful methods. At all frequencies, the bilateral difference in CPT and PT values at the mental foramen and buccal shelf region was not significant.Conclusion: CPT and PT measurements using a custom-made device that applied an electrical current to the mental foramen region have appropriate reliability to assess intra-oral sensitivity to electrical stimulation in young adults. K E Y W O R D Scurrent stimulus, oral cavity, oral mucosa, pain threshold, reliability, transcranial direct current stimulation

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“…The validity of the method is comparable to the more popular standard sensory testing techniques, including thermal and vibration detection thresholds (Masson & Boulton, ; Pitei, Watkins, Stevens, & Edmonds, ). Furthermore, we have developed electrical current stimulation for use in oral sensory measurements and have reported that both CPT and PT can be useful in assessing changes in oral sensation in denture wearers (Ito, Kimoto, & Kawai, ; Kimoto et al ., ; Nakashima et al ., ). The CPT and PT measured by the device could potentially applied to oral sensory measurements in patients with DM as well.…”

Section: Introductionmentioning

confidence: 97%

Measurement reliability of current perception threshold and pain threshold in parallel with blood sampling

Ogawa

Kimoto

Nakashima

et al. 2017

Clinical & Exp Dental Res

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The irritation and pain associated with oral blood sampling necessary to monitor glycemic control can alter oral sensation, but no studies have measured the reliability of oral sensation testing when performed concurrently with blood sampling. The primary and secondary aims of this study were to verify the measurement reliability of current perception threshold (CPT) and pain threshold (PT) tests performed before and after blood sampling and to investigate the differences in CPTs/PTs obtained from the oral cavity, hand, and foot, respectively. CPT/PT measurements were obtained from the oral mucosa and the tips of fingers and toes of 18 volunteers (10 males and 8 females, average age = 26.3 years) using electrical stimulation at frequencies of 5, 250, and 2,000 Hz. Participants also provided blood samples by pricking their own index fingers with a small needle. All subjects completed the following 3 conditions at once‐weekly intervals as follows: (a) sensory measurements followed by blood sampling (SB block); (b) blood sampling followed by sensory measurements (BS block); (c) sensory measurements without blood sampling (CO control block). Cronbach's α coefficients were over 0.78 for the SB, BS, and CO blocks, and are considered to be acceptable for assuring measurement reliability. The oral cavity had significantly lower CPT/PTs than both hands and feet, such that the threshold increased in the order oral cavity < hand < foot. CPT and PT measurements performed concurrently with blood sampling are both reliable and region specific, and for which the oral cavity is the most sensitive testing region.

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Characteristics of the pain tolerance threshold induced by electrical stimulation of the alveolar ridge

Cited by 5 publications

References 25 publications

Electrostimulation of the lingual nerve by an intraoral device may lead to salivary gland regeneration: A case series study

Electrostimulation of the lingual nerve by an intraoral device may lead to salivary gland regeneration: A case series study

Verification of the reliability of current perception threshold and pain threshold testing by application of an electrical current stimulus to mandibular mucosa in young adults

Measurement reliability of current perception threshold and pain threshold in parallel with blood sampling

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