Characteristics of the PET Component of a Dedicated Breast PET/CT Scanner Prototype

Wu, Yue; Yang, Kai; Packard, N.; Fu, Lin; Stickel, Jennifer; Tran, V.H.; Qi, Jinyi; Boone, John M.; Cherry, Simon R.; Badawi, Ramsey D.

doi:10.1109/nssmic.2006.354382

Cited by 10 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The integrated gantry is illustrated in figure 1. In the prototype described by Wu et al (2006), the PET detectors had one degree of freedom (rotation), but the current PET gantry has three MDrive23 stepper motors (Intelligent Motion Systems, Inc., Marlborough, CT) that control vertical, horizontal and rotational motion. The motors are programmed by the computer through RS-485 interfaces and the programs are stored in their nonvolatile memories.…”

Section: System Descriptionmentioning

confidence: 99%

“…The combination of these advantages and limitations motivated the construction of a combined dedicated high-resolution breast PET/CT system at UC Davis. It consists of a dedicated breast CT scanner and a dual-headed flat-panel lutetium oxyorthosilicate (LSO) PET scanner based on components described in Doshi et al (2001), Lamare et al (2005) and Wu et al (2006). The gantry for the PET component has been redesigned, a new control interface built, new acquisition electronics added and new software written to control the device.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

PET characteristics of a dedicated breast PET/CT scanner prototype

Bowen

Yang

et al. 2009

Phys. Med. Biol.

Self Cite

View full text Add to dashboard Cite

A dedicated breast PET/CT system has been constructed at our institution, with the goal of having increased spatial resolution and sensitivity compared to whole-body systems. The purpose of this work is to describe the design and the performance characteristics of the PET component of this device. Average spatial resolution of a line source in warm background using maximum a posteriori (MAP) reconstruction was 2.5 mm, while average spatial resolution of a phantom containing point sources using filtered back projection (FBP) was 3.27 mm. A sensitivity profile was computed with a point source translated across the axial field of view (FOV) and the peak sensitivity of 1.64% was measured at the center of FOV. Average energy resolution determined on a per-crystal basis was 25%. Characteristic dead time for the front-end electronics and data acquisition (DAQ) was determined to be 145 ns and 3.6 µs, respectively. With no activity outside the FOV, a peak noise-equivalent count rate of 18.6 kcps was achieved at 318 µCi (11.766 MBq) in a cylindrical phantom of diameter 75 mm. After the effects of exposing PET detectors to x-ray flux were evaluated and ameliorated, the combined PET/CT scan was performed. The percentage standard deviations of uniformity along axial and transaixal directions were 3.7% and 2.8%, respectively. The impact of the increased reconstructed spatial resolution compared to typical whole-body PET scanners is currently being assessed in a clinical trial.

show abstract

Section: System Descriptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PET characteristics of a dedicated breast PET/CT scanner prototype

Bowen

Yang

et al. 2009

Phys. Med. Biol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…3,4 However, special considerations on detector design and system architecture need to be taken into account given the demands for high spatial resolution and high photon sensitivity in order to detect early stages of breast cancer, which cannot be satisfied with the current clinical tomograph designs. [5][6][7][8][9] Breast-dedicated PET systems have recently demonstrated their clinical relevance, 10 whereas specialized system designs may be used to improve system performance. 11 Our group is developing a 1 mm 3 resolution PET scanner dedicated to breast imaging.…”

Section: Introductionmentioning

confidence: 99%

Physical effects of mechanical design parameters on photon sensitivity and spatial resolution performance of a breast‐dedicated PET system

et al. 2010

View full text Add to dashboard Cite

Purpose: This study aims to address design considerations of a high resolution, high sensitivity positron emission tomography scanner dedicated to breast imaging. Methods: The methodology uses a detailed Monte Carlo model of the system structures to obtain a quantitative evaluation of several performance parameters. Special focus was given to the effect of dense mechanical structures designed to provide mechanical robustness and thermal regulation to the minuscule and temperature sensitive detectors. Results: For the energies of interest around the photopeak ͑450-700 keV energy window͒, the simulation results predict a 6.5% reduction in the single photon detection efficiency and a 12.5% reduction in the coincidence photon detection efficiency in the case that the mechanical structures are interspersed between the detectors. However for lower energies, a substantial increase in the number of detected events ͑approximately 14% and 7% for singles at a 100-200 keV energy window and coincidences at a lower energy threshold of 100 keV, respectively͒ was observed with the presence of these structures due to backscatter. The number of photon events that involve multiple interactions in various crystal elements is also affected by the presence of the structures. For photon events involving multiple interactions among various crystal elements, the coincidence photon sensitivity is reduced by as much as 20% for a point source at the center of the field of view. There is no observable effect on the intrinsic and the reconstructed spatial resolution and spatial resolution uniformity. Conclusions: Mechanical structures can have a considerable effect on system sensitivity, especially for systems processing multi-interaction photon events. This effect, however, does not impact the spatial resolution. Various mechanical structure designs are currently under evaluation in order to achieve optimum trade-off between temperature stability, accurate detector positioning, and minimum influence on system performance.

show abstract

“…Further, for registering the template to the target, we formulate the warping as a constrained optimization problem and present a method to solve it. We demonstrate the application of our segmentation scheme for a PSPMT-based detector module, a PSAPD-based detector evaluated for use in a high resolution PET scanner (Yang et al 2006), and the PET component of the UC Davis dedicated breast PET/CT scanner that uses a (4 × 4) array of segmented LSO blocks and PSPMTs (Doshi et al 2001, Wu et al 2006). Photographs and a design drawing of the detector configurations are shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Crystal identification in positron emission tomography using nonrigid registration to a Fourier-based template

et al. 2008

View full text Add to dashboard Cite

Modern Positron Emission Tomography (PET) detectors typically are made from 2D modular arrays of scintillation crystals. Their characteristic flood field response (or flood histogram) must be segmented in order to correctly determine the crystal of annihilation photon interaction in the system. Crystal identification information thus generated is also needed for accurate system modeling as well as for detailed detector characterization and performance studies. In this paper, we present a semi-automatic general purpose template-guided scheme for segmentation of flood histograms. We first generate a template image that exploits the spatial frequency information in the given flood histogram using Fourier-space analysis. This template image is a lower order approximation of the flood histogram, and can be segmented with horizontal and vertical lines drawn midway between adjacent peaks in the histogram. The template is then registered to the given flood histogram by a diffeomorphic polynomial-based warping scheme that is capable of iteratively minimizing intensity differences. The displacement field thus calculated is applied to the segmentation of the template resulting in a segmentation of the given flood histogram. We evaluate our segmentation scheme for a photomultiplier tube-based PET detector, a detector with readout by a position-sensitive avalanche photodiode (PSAPD) and a detector consisting of a stack of photomultiplier tubes and scintillator arrays. Further, we quantitatively compare the performance of the proposed method to that of a manual segmentation scheme using reconstructed images of a line source phantom. We also present an adaptive method for distortion reduction in flood histograms obtained for PET detectors that use PSAPDs.

show abstract

Characteristics of the PET Component of a Dedicated Breast PET/CT Scanner Prototype

Cited by 10 publications

References 6 publications

PET characteristics of a dedicated breast PET/CT scanner prototype

PET characteristics of a dedicated breast PET/CT scanner prototype

Physical effects of mechanical design parameters on photon sensitivity and spatial resolution performance of a breast‐dedicated PET system

Crystal identification in positron emission tomography using nonrigid registration to a Fourier-based template

Contact Info

Product

Resources

About