Characteristics of Three Person-to-Person Transmission Clusters of Severe Fever with Thrombocytopenia Syndrome in Southeastern China

Tao, Mingyong; Liu, Ying; Li, Feng; Zhang, Rong; Shi, Xuguang; Ren, Jiangping; Guo, Shuaiqi; Sun, Jimin; Jiang, Jianmin

doi:10.4269/ajtmh.21-0366

Cited by 8 publications

(9 citation statements)

References 28 publications

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“…Our study also has limitations. First, the SFTSV can be transmitted from person to person through contact with the infected patient's blood or mucus [ 39 , 40 ]. However, we could not exclude these family clusters of SFTS cases.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Characteristics and Risk Factors of Severe Fever With Thrombocytopenia Syndrome in Yantai City, Shandong Province

Hou¹,

Zhang²,

Liu³

et al. 2023

Open Forum Infectious Diseases

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Background To better understand the epidemiological characteristics and risk factors associated with the incidence of severe fever with thrombocytopenia syndrome (SFTS) in Yantai City, Shandong Province, China. Methods The SFTS data from 2010 to 2019 were obtained from the National Notifiable Disease Reporting System, and visualization was performed using ArcGIS 10. A community-based, 1:2 matched case-control study was conducted to investigate the risk factors for SFTS in Yantai City. Standardized questionnaires were used to collect detailed information about the demographics and risk factors for SFTSV infection. Results A total of 968 laboratory-confirmed SFTS cases were reported, 155 (16.01%) of which were fatal. The SFTS epidemic curve revealed that most cases occurred from May to August, accounting for 77.27% of all studied cases. The SFTS cases were mainly distributed in Lai Zhou, Penglai, Zhaoyuan, Haiyang, and Qixia from 2010 to 2019 (accounting for 83.47% of all cases). No differences in demographics were observed between the cases and controls. In the multivariate analysis, presence of rats in the household (OR=2.89, 95%CI=1.94-4.30), bitten by the ticks one month before the onset of symptoms (odds ratio [OR]=15.97, 95% confidence interval [CI]=5.36-47.60), and presence of weeds and shrubs around the house (OR=1.70, 95%CI=1.12-2.60) were found to be the risk factors for SFTS. Conclusions Our results support the hypothesis that ticks are important vectors of the SFTS virus. Education on SFTS prevention and personal hygiene should be imparted in high-risk populations, especially among outdoor workers living in SFTS-endemic areas, while vector management should also be considered.

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Section: Discussionmentioning

confidence: 99%

Epidemiological Characteristics and Risk Factors of Severe Fever With Thrombocytopenia Syndrome in Yantai City, Shandong Province

Hou¹,

Zhang²,

Liu³

et al. 2023

Open Forum Infectious Diseases

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“…Human-to-human events of SFTSV have attracted urgent public health concern [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. Research about SFTSV excretion from patient's body and PPEs application of HCWs against human-to-human transmission was sparsely investigated.…”

Section: Discussionmentioning

confidence: 99%

“…The SFTSV infection was primarily transmitted from infected tick to human. In addition to tick transmission, human-to-human transmission of SFTS had been widely reported and mostly caused by unprotected exposure to individuals with SFTS disease [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. A strong risk factor linked to human-tohuman SFTSV spread is contact with infected bodily uids.…”

Section: Intruductionmentioning

confidence: 99%

Viral shedding pattern of severe fever with thrombocytopenia syndrome virus in severely ill patients:A Prospective, Multicenter Study

Hu,

Bian,

Chen

et al. 2024

Preprint

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Background. Severe fever with thrombocytopenia syndrome (SFTS) is spreading rapidly in Asia. The pathway of SFTS virus shedding from patient and specific use of personal protective equipments (PPEs) against viral transmission have rarely been reported. Methods. A multicenter cohort study was performed to determine SFTS virus (SFTSV) level from blood, throat swabs, fecal/ anal swabs, urine and bedside environment swabs of SFTS patients by qRT-PCR. PPEs were applied in healthcare workers based on the pathway of SFTSV shedding and occurrence of hemorrhagic signs in patients. Results. A total of 189 SFTSV-confirmed patients were included in the study, 54 patients died (case fatality rate, 28.57%). Positive SFTSV in throat swabs (T-SFTSV), fecal /anal swabs (F-SFTSV) and urine (U-SFTSV) were detected in 121 (64.02%), 91 (48.15%) and 65 (34.4%) severely ill patients, respectively. The levels of T-SFTSV, F-SFTSV and U-SFTSV were positively correlated with the load of SFTSV in blood. We firstly revealed that SFTSV positive rate of throat swabs were correlated with occurrence of pneumonia and case fatality rate of patients (P < 0.0001). Specific precaution measures were applied by healthcare workers in participating cardiopulmonary resuscitation and orotracheal intubation for severely ill patients with positive T-SFTSV, no event of SFTSV human-to-human transmission occurred after application of effective PPEs. Conclusions. Our research demonstrated SFTSV could shed out from blood, oropharynx, feces and urine in severely ill patients. The excretion of SFTSV from these parts was positively correlated with viral load in the blood. Effective prevention measures against SFTSV human-to-human transmission are needed.

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“…According to the China national "Guideline for Prevention and Treatment of Severe Fever with Thrombocytopenia Syndrome (2010 version)" (Tao et al, 2021), individuals with an epidemiological history and clinical symptoms, such as fever, reduced platelets, and white blood cells, can be diagnosed with SFTS if they meet at least one of the following laboratory criteria: (1) isolation of SFTSV from patient specimens; (2) detection of SFTSV RNA in serum or blood samples; or (3) a four-fold increase of virus-specific IgG and/or IgM antibody titers in convalescent serum compared to the acute phase.…”

Section: Diagnosis Of Sftsmentioning

confidence: 99%

Differential Short-term and Long-term Metabolic and Cytokine Responses to Infection of Severe Fever with Thrombocytopenia Syndrome Virus

zhang,

Hu,

Zheng

et al. 2023

Preprint

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Introduction Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the SFTS bunyavirus (SFTSV), which has a wide geographic distribution. The primary clinical manifestations of SFTS are fever and thrombocytopenia, with multiorgan failure being the leading cause of death. While most patients recover with treatment, little is known about the potential long-term metabolic effects of SFTSV infection. Objectives The aim of this study was to light on dysregulated metabolic pathways and cytokine responses following SFTSV infection, which pose significant risks to the short-term and long-term health of affected individuals. Methods In this study, we used untargeted metabolomics to obtain the relative abundance of plasma metabolites from 14 SFTS patients, 18 IgG positive healthy controls and 20 IgG negative healthy controls, respectively, using ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC-MS). Additionally, the concentrations of 12 cytokines were quantified through mean fluorescence intensity (MFI) measurements. Results and Conclusion We screened 122 long-term metabolites and 108 short-term metabolites by analytical comparison and alalyzed their correlations with 12 cytokines. Glycerophospholipid metabolism (GPL) was identified as significant short-term metabolic pathway suggesting that the activation of GPL might be linked to the self-replication of SFTSV, whereas pentose phosphate pathway and alanine, aspartate, and glutamate metabolism were indicated as significant long-term metabolic pathways playing a role in combating long-standing oxidative stress in the patients. Furthermore, we propose that α-ketoglutarate could serve as a dietary supplement to protect recovering SFTS patients, potentially providing a new perspective for the treatment of SFTS patients.

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Characteristics of Three Person-to-Person Transmission Clusters of Severe Fever with Thrombocytopenia Syndrome in Southeastern China

Cited by 8 publications

References 28 publications

Epidemiological Characteristics and Risk Factors of Severe Fever With Thrombocytopenia Syndrome in Yantai City, Shandong Province

Epidemiological Characteristics and Risk Factors of Severe Fever With Thrombocytopenia Syndrome in Yantai City, Shandong Province

Viral shedding pattern of severe fever with thrombocytopenia syndrome virus in severely ill patients:A Prospective, Multicenter Study

Differential Short-term and Long-term Metabolic and Cytokine Responses to Infection of Severe Fever with Thrombocytopenia Syndrome Virus

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