Characteristics of waterborne polyurethane/poly(<i>N</i>‐vinylpyrrolidone) composite films for wound‐healing dressings

Yoo, Hyung Joun; Kim, Han‐Do

doi:10.1002/app.26970

Cited by 57 publications

(39 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, it could be due to the existence in intermolecular interactions between Ch and PEGF molecules [34]. The results, ranging from 553±53 to 733±55 g m −2 day −1 , are comparable with the commercially available wound dressings in market such as Tegaderm and Op Site with 491±41 and 792±32 g m −2 day −1 , respectively [4,35]. Considering accepted optimal WVTR value, these photocured films are promising candidates for dressing the wounds with low exudate.…”

Section: Water Vapor Transmissionsupporting

confidence: 67%

Potential Application of a Visible Light-Induced Photocured Hydrogel Film as a Wound Dressing Material

Doulabi

Mirzadeh

Samadi

et al. 2015

Journal of Polymers

View full text Add to dashboard Cite

The objective of this work was to prepare hydrogel films, as semi-interpenetrating polymer networks (semi-IPN), based on polyethylene glycol-co-fumarate (PEGF) and chitosan (Ch) blends. Hydrogel films were prepared by free radical cross-linking of PEGF, an unsaturated aliphatic polyester, in the presence of N-vinyl pyrrolidone (NVP), camphorquinone (CQ), and N,N-dimethylp-toluidine (DMPT) as a cross-linking, photoinitiating, and accelerating agent, respectively. The effect of NVP concentration on physicochemical and biological properties of semi-IPN film properties was evaluated. The sol fraction, water vapor transmission rate, and swelling degree of the hydrogel films were also investigated. Antibacterial activity against S. aureus was observed for the photocured blend hydrogels of Ch/PEGF with no toxicity to L929 cells according to the cell viability assays. Blend hydrogel films showing 600 ± 88% of equilibrium swelling degree in water and the lowest sol fraction (3.14 ± 1.22%) were obtained at 20 wt% of NVP content whilst preserving their own cytocompatibility and antibacterial activity. Therefore, this formulation was considered as an optimal semi-IPN blend hydrogel film composition with potential application for wound dressing.

show abstract

Section: Water Vapor Transmissionsupporting

confidence: 67%

Potential Application of a Visible Light-Induced Photocured Hydrogel Film as a Wound Dressing Material

Doulabi

Mirzadeh

Samadi

et al. 2015

Journal of Polymers

View full text Add to dashboard Cite

show abstract

“…To prevent scab formation due to excessive dehydration and desiccation of wounds, a dressing with a sufficient water vapor transmission rate is required . Generally, occlusive dressings need not to have high absorptive capacity, but they should transmit moisture vapor with a rate less than 300 g m −2 day −1 to maintain moisture in low exudative wounds .…”

Section: Resultsmentioning

confidence: 99%

Preparation and characterization of novel antibacterial castor oil-based polyurethane membranes for wound dressing application

Yari

Yeganeh

Bakhshi

et al. 2013

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

Preparation of novel antibacterial and cytocompatible polyurethane membranes as occlusive dressing, which can provide moist and sterile environment over mild exudative wounds is considered in this work. In this regard, an epoxy-terminated polyurethane (EPU) prepolymer based on castor oil and glycidyltriethylammonium chloride (GTEAC) as a reactive bactericidal agent were synthesized. Polyurethane membranes were prepared through cocuring of EPU and different content of GTEAC with 1,4-butane diamine. The physical and mechanical properties, as well as cytocompatibility and antibacterial performance of prepared membranes were studied. Depending on their chemical formulations, the equilibrium water absorption and water vapor transmission rate values of the membranes were in ranges of 3-85% and 53-154g m(-2) day(-1), respectively. Therefore, these transparent membranes can maintain for a long period the moist environment over the wounds with low exudates. Detailed cytotoxicity analysis of samples against mouse L929 fibroblast and MCA-3D keratinocyte cells showed good level of cytocompatibility of membranes after purification via extraction of residual unreacted GTEAC moieties. The antibacterial activity of the membranes against Escherichia coli and Staphylococcus aureus bacteria was also studied. The membrane containing 50% GTEAC exhibited an effective antibacterial activity, while showed acceptable cytocompatibility and therefore, can be applied as an antibacterial occlusive wound dressing.

show abstract

“…46 In hydrated state, when membranes are in contact with uid, much higher values may be recorded for the prepared membranes. This phenomenon can be attributed to either hydrophobic nature of AT segments, or barrier effect of p-p stacked AT moieties against water molecules.…”

Section: Hydrophilicity and Water Uid Handling Capacity Of Wound Drementioning

confidence: 99%

Aniline tetramer embedded polyurethane/siloxane membranes and their corresponding nanosilver composites as intelligent wound dressing materials

Gharibi¹,

Yeganeh²,

Gholami³

et al. 2014

RSC Adv.

View full text Add to dashboard Cite

The preparation of functional intelligent wound dressing membranes with features including: excellent dimensional stability in both dry and hydrated states, preserving a moist environment over the wounded area by self-adjustment of their permeability in response to wound moisture level, a broad spectrum of antimicrobial activity towards different microorganisms, promising antioxidant (radical scavenging) efficiency and significant activity for stimulation of fibroblast cells growth and proliferation is reported in this work. For the preparation of dressing membranes, NCO-terminated polyurethane prepolymers and a CHO-terminated aniline tetramer are functionalized with silane groups. Polyurethane/siloxane networks are prepared through a sol-gel reaction of these components at different weight ratios. The corresponding nanosilver composites are simply prepared by a redox reaction through impregnating the membranes with a silver salt solution. Based on various in vitro tests, it is revealed that some of the prepared membranes have the basic characteristics of ideal dressings, while they can actively alleviate the healing of tissue in the wounded area. View Article Onlinea According to analysis of variances P-values of <0.05 were considered signicant. The difference between quantities with similar superscripts is not signicant (p $ 0.05) for data of each column.This journal is

show abstract

Characteristics of waterborne polyurethane/poly(N‐vinylpyrrolidone) composite films for wound‐healing dressings

Cited by 57 publications

References 28 publications

Potential Application of a Visible Light-Induced Photocured Hydrogel Film as a Wound Dressing Material

Potential Application of a Visible Light-Induced Photocured Hydrogel Film as a Wound Dressing Material

Preparation and characterization of novel antibacterial castor oil-based polyurethane membranes for wound dressing application

Aniline tetramer embedded polyurethane/siloxane membranes and their corresponding nanosilver composites as intelligent wound dressing materials

Contact Info

Product

Resources

About