Characteristics, Therapies, and Outcome of Children With Necrotizing Soft Tissue Infections

Abstract

NSTIs are a rare but significant diseases in children. It seems that, as in the adult population, prompt surgical debridement is the most important intervention. Corticosteroid therapy may be associated with a worse prognosis.

Necrotising fasciitis withEscherichia coliin a newborn infant after abdominal surgery

“…The incidence and death rates of NF have changed little over the last 10 years1 and neonatal mortality may be as high as 59% 2…”

Pulmonary Tuberculosis in Children

“…Some infants have difficulty in getting weight and growing up. Some infants and young children with bronchial obstruction show localized wheezing or decreased breath sounds that may be accompanied by tachypnea or respiratory distress (1,(4)(5)(6)(7)(8)(9). In pediatric pulmonary tuberculosis, the radiographic hallmark is the relatively large size and importance of lymphadenopathy compared with the less significant size of the parenchymal infiltration.…”

“…The clinical and physical manifestations of disease tend to be different by the age of onset of disease. Pre-school children and adolescents are more likely to have significant signs or symptoms, whereas school-age children often have clinically silent disease (1,(4)(5)(6)(7)(8)(9)(10). Half of young children with radiographically moderate to severe pulmonary TB don't have any symptoms or physical findings and, mainly, are detected by contact tracing of an adult with pulmonary TB.…”

“…These are 1-5 microns in diameter. These infectious droplet nuclei are released when persons with pulmonary or laryngeal tuberculosis cough, sneeze, or laugh, Droplet nuclei remain suspended in the air for up to several hours (1,2,(6)(7)(8)(9)(10). Patients with high loads of bacteria in their sputums are more likely to transmit the infection than those with a low numbers of bacteria.…”

“…The two main factors detecting the risk of progression to disease are patient's age and immune status (4)(5)(6)(7)(8)(9). Neonates are at higher risk of progression of infection to disease, with higher rate of military TB and meningeal involvement.…”