Necrotising fasciitis withEscherichia coliin a newborn infant after abdominal surgery

Extensive monomicrobial necrotizing fasciitis and myonecrosis of left hemi trunk in a healthy 41-year-old man with COVID-19 infection

“…Shaked et al ( 13 ) reported, seven patients from a hospital had necrotizing fasciitis associated with E. coli, but in contrast to our patient, each one had some form of immunodeficiency, and all had a fatal result. Similar to the current case report, successful treatment with timely surgical debridement, strong proprietary antimicrobial therapy, and invasive supportive care such as Vacuum-assisted wound closure (VAC) has been reported in some infant and adult patients ( 10 , 14 ).…”

“…Chen et al showed that among 126 patients with necrotizing fasciitis caused by E. coli, only in 2 patients (1.6%) were found as a monomicrobial agent ( 9 ). Necrotized fasciitis due to E. coli has been reported in infants following surgery ( 10 ) or Iron-Overloaded ( 11 ). Nazir et al noted that one of the factors that enhanced microbial virulence and increased E. coli proliferation is iron overload ( 11 ).…”

Draft Genome Sequence of a Necrotoxigenic Escherichia coli Isolate

“…It is usually caused by Streptococcus pyogenes ( 8 , 9 ), sometimes Staphylococcus aureus ( 10 ) or by a mixture of microorganisms including Streptococcus , S. aureus , Enterobacteriaceae , and some anaerobes ( 11 , 12 ). On rare occasions, necrotoxigenic E. coli was identified as the etiologic agent in chronically ill patients ( 13 – 20 ) or infants following surgery ( 21 , 22 ). Recently, we reported a lethal case of very rapidly evolving necrotizing fasciitis.…”

Necrotizing fasciitis and infective endocarditis caused by Escherichia coli in a hemodialysis patient

“…E. coli has been isolated in polymicrobial NF in up to 6.5% of cultures from necrotic tissue, but is only rarely a cause of monomicrobial NF. Some of the previous cases had large bullae, as in our case, although this presentation occurs in only 15% of cases . NF most commonly develops after trauma, surgery, and skin infection, especially in immunocompromised patients, such as those with diabetes mellitus, malignancy, alcoholism, or chronic renal failure .…”