Characterization and antihypertensive activity of ginger extract-eel bone oil SNEDDS (selfnanoemulsifying drug delivery system)

Prihapsara, Fea; Wijayanti, Imas Ifrian; Budiharjo, Agung; Pangastut, Artini; Artanti, Anif Nur

doi:10.29090/psa.2021.01.19.120

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“…Following the administration and a mild agitation in the gastrointestinal tract. SNEDDS disperses to develop fine oil-in-water nanoemulsion to enhance the dissolution and absorption and subsequently enhance the bioavailability of the active ingredients 13 .…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of SNEDDS of Pandanus tectorius Fruit Extract and in vitro Antioxidant Activity

et al. 2022

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Excess reactive oxygen species can cause oxidative stress and lead to the progression of cardiovascular diseases. Pandanus tectorius fruit (PTF) is a promising source of herbal medicine with antioxidant activity. However, the oral administration is hindered due to the semi-polar properties of the extract. The solubility of the extract can be potentially improved through synthesis of a self-nanoemulsifying drug delivery system (SNEDDS). This study aims to formulate nanoemulsion of the extract by means of self-nanoemulsification approach using caprylic triglycerides, kolliphor RH40, and propylene glycol. It was found that when tested in water, simulated gastric, and intestinal fluid, PTF-SNEDDS had emulsification times of 38.17, 49.44, and 45.29 sec, indicating grade A formulation. The clarity level of PTF-SNEDDS, particle size, and zeta potential was at 99.3%, 41.5 ± 1.1 nm, and -25.9 mV. The antioxidant activity of PTF-SNEDDS was 1.6 times higher than PTF extracts. It can be concluded that PTF extract can be formulated into SNEDDS and stable in gastrointestinal conditions.

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Section: Introductionmentioning

confidence: 99%