Characterization and antioxidant activity of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum

Fruiting body, spores and in vitro produced mycelium of Ganoderma lucidum from Northeast Portugal: A comparative study of the antioxidant potential of phenolic and polysaccharidic extracts

“…There are some reports regarding antioxidant properties of G. lucidum methanolic (Mau et al, 2002) and aqueous (Lin, Lin, Chen, Ujiie, & Takada, 1995) extracts, but also of its polysaccharides (Jia et al, 2009;Ping, Yan, Bing, Guo, Yun, & Ping, 2009;Liu, Wang, Pang, Yao, & Gao, 2010;Kozarski et al, 2011) and phenolic compounds (Kim et al, 2008). Phenolic compounds possess an established antioxidant capacity and their antiradical mechanism has almost completely revealed (Ferreira, Barros, & Abreu, 2009).…”

“…Phenolic compounds possess an established antioxidant capacity and their antiradical mechanism has almost completely revealed (Ferreira, Barros, & Abreu, 2009). Regarding polysaccharides, their antioxidant properties have been evaluated by the free radical scavenging abilities of 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical, superoxide radical, conjugated diene method, reducing power and chelating effects on ferrous ions Liu et al, 2010;Kozarski et al, 2011). Their radical scavenging activity seems to be related to an increase in the antioxidant enzyme activities: superoxide dismutase (SOD) which catalyzes dismutation of superoxide anion to hydrogen peroxide, catalase (CAT) which detoxifies hydrogen peroxide and converts lipid hydroperoxides to nontoxic substances, and glutathione peroxidase (GPx) which maintains the levels of reduced glutathione (GSH) Ping et al, 2009).…”

Ganoderma Lucidum Polysaccharides Target a Fas/Caspase Dependent Pathway to Induce Apoptosis in Human Colon Cancer Cells

“…Polysaccharides from herb plants especially mushroom have been proven to be effective anti-tumor compounds with no toxicity (Shi et al, 2013;Giavasis, 2014;Ning et al, 2014). It has been reported that GLP exert strong anti-tumor effect when the molecular weight was larger than 1×10 4 (Liu et al, 2010). The reasons may be that polysaccharides with molecules weight in the range have not only a good dissolubility in water but also a relative complex structure (Dai et al, 2013).…”

“…Previous studies have showed that GLP can mediate cytotoxicity in number of cancer cell lines including lung cancer, prostate cancer and breast cancer. Further studies showed that GLP programmed cell death through endothelial growth factor overexpression and tumor angiogenesis inhibition in highly metastatic mouse melanoma B16F10 cells (Sun et al, 2011), through endotoxin-induced intercellular cell adhesion molecule-1 (ICAM-1) upregulation in the neointima in mice (Liu et al, 2010), through cell differentiation and p53 activation in human monocytic leukemia THP-1 cells (Hsu et al, 2011), through activation of mitochondrial signaling pathway in MCF-7 breast cancer cells (Shang et al, 2011). GLP can also boost anticancer immunity by changing lymphocyte phenotype in H22 hepatoma mice (Zhou et al, 2009), by enhancing CD56 + NK-cell cytotoxicity in cord blood (Chien et al, 2004), by promoting the proliferation of B cells in mice (Jiang et al, 2003).…”

Characterization, antioxidant activities and hepatoprotective effects of polysaccharides from pre-pressing separationFujiapple peel

“…Numerous biological and photochemical reactions can generate this free radical that may subsequently form secondary radicals including hydrogen peroxide and hydroxyl radical through dismutation reaction and lead to tissue damages and even various cancers (Liu, Wang, Pang, Yao, & Gao, 2010). Therefore, the determination of scavenging effect on O 2 •− is a necessary way to elucidate the mechanism of antioxidant activity (Wade, Jackson, Highton, & Vanrij, 1987).…”