Characterization and bioactive properties of zirconia based polymeric hybrid for orthopedic applications

Abstract

Zirconia is a transition metal oxide with current applications to orthopedic implants. It has been shown to up-regulate specific genes involved in bio-integration and injury repair. This study examines the effects of zirconia and polydimethylsiloxane (PDMS) hybrids on the proliferation and viability of human primary osteoblast and fibroblast cells. In this study, zirconia-PDMS hybrid coatings were synthesized using a modified sol gel process. The hybrid material was characterized using optical microscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, and contact angle analysis. This study demonstrates that Zr-PMDS surface materials display hydrophobic surface properties coupled with a preferential deposition of polymer near the surface. Primary osteoblast and fibroblast proliferation and viability on hybrid coated surfaces were evaluated via a rapid screening methodology using WST-1 and calcein AM assays. The cells were seed at 5,000 cells per well in 96-well plates coated with various composition of Zr-PDMS hybrids. The results showed increasing cell proliferation with increasing zirconia concentration, which peaked at 90 % v/v zirconia. Proliferation of osteoblasts and fibroblasts displayed similar trends on the hybrid material, although osteoblasts displayed a bi-phasic dose response by the calcein AM assay. The results of this current study show that Zr-PDMS may be used to influence tissue-implant integration, supporting the use of the hybrid as a promising coating for orthopedic trauma implants.

Study on microstructure and wear resistance of Zr-17Nb alloy irradiated by high current pulsed electron beam

“…The presence of these phases can significantly improve the tensile strength and creep resistance of the alloy. Zr-based alloys have high corrosion resistance in high-temperature aqueous solutions, good mechanical properties, and resistance to radiation damage, which are widely used in aerospace [4], military [5], nuclear reaction [6], atomic energy [7], chemical engineering [8], marine engineering, medicine [8], biology and so on [9]. At present, many research scientists are shifting their focus to the mechanical properties of Zrbased alloys to expand further the application potential of Zr in the structural field [10][11][12][13].…”

Fabrication of durable super-repellent surfaces on cotton fabric with liquids of varying surface tension: Low surface energy and high roughness

“…After zirconia-siloxane coating on cotton fabric, new peaks of the elements Zr (Zr 3d, 181.12 eV) and Si (Si 2p, 101.0 eV and Si 2s 152.0 eV) appeared (Fig. 6b) [5,31]. In addition, high resolution of Si 2p and Zr 3d peaks are shown in Fig.…”

Surface engineering of biodegradable implants: emerging trends in bioactive ceramic coatings and mechanical treatments

“…Hip implants 74 and dental implants 75 prepared from zirconia have shown long-term clinical success because of its good biocompatibility, strength, and wear resistance. Zirconia has been reported to activate the BMP4 gene 76 . This gene is involved in early bone development and induces bone growth.…”

“…Thomas et al demonstrated that zirconia-polydimethylsiloxane hybrid film improves the growth and viability of osteoblasts and fibroblasts. Thus, coating prepared using this hybrid material enhances the bio-integration at the tissue-implant interface 76 . Seweryn et al reported the atomic layer deposition technique to generate uniform thickness zirconia coating on the substrate.…”