Characterization and determination of PCB isomers by high resolution gas chromatography and HRGC/mass spectrometry

Onuska, Francis I.; Terry, K. A.

doi:10.1002/jhrc.1240091116

Cited by 26 publications

(15 citation statements)

References 13 publications

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“…Capillary gas chromatography (GC) with an electron capture detector (ECD), or a mass spectrometric detector in the selected-ion monitoring mode (MS-SIM), provides the best specificity and selectivity for trace analysis of polychlorinated biphenyls (PCBs) in various environmental and biological samples [1]. It is known that the ECD response to PCBs is dependent both on the number of chlorine atoms present as well as on the chlorine substitution pattern on the biphenyl skeleton [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

“…It is known that the ECD response to PCBs is dependent both on the number of chlorine atoms present as well as on the chlorine substitution pattern on the biphenyl skeleton [1,3,4]. Owing to very poor reproducibility, published responses and response factors cannot simply be applied for calibration under various instrumental and working conditions.…”

Section: Introductionmentioning

confidence: 99%

“…A mixture of nine reference PCB congeners was used for the calibration of MS-SIM mean responses of isomeric groups, using a computerized capillary GC-MS system [6]. Individual response factors within an isomer group, however, varied by a factor of 1.16-2.15 [1] or 1.3--4.6 [6], which is almost unacceptable for trace GC-MS-SIM analysis.…”

Section: Introductionmentioning

confidence: 99%

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Reference standards for quantitative trace analysis of PCB's by GC. Technical PCB formulations for the calibration of ECD and MSD responses

et al. 1993

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SummaryThe composition of any technical PCB formulation can be determined directly by analyzing the PCB sample by gas chromatography with a flame ionization detector (GC-FID), provided the relative molecular masses of the components are known. The responses of electron capture and selected-ion monitoring, mass-spectra detectors can then be calibrated for individual PCB congeners by correlation of the chromatographic patterns with those of concentrated PCB samples obtained by GC-FID. This procedure, which uses a given technical PCB formulation as a secondary reference standard mixture, is to be preferred over existing calibration methods, when results with + 10 % errors are acceptable because commercial PCB formulations cover the whole range of chlorination products.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reference standards for quantitative trace analysis of PCB's by GC. Technical PCB formulations for the calibration of ECD and MSD responses

et al. 1993

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“…At present, high resolution capillary gas liquid chromatography (HRGC) with an electron capture detector (ECD), or a mass spectrometric detector in the selected ion monitoring mode (MS-SIM), provide the best specificity and selectivity for trace analysis of polychlorinated biphenyls (PCB's) in various environmental and biological samples [1]. It is, however, necessary to calibrate the detector response against standards for each PCB to be detcrmined [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…It is, however, necessary to calibrate the detector response against standards for each PCB to be detcrmined [1,2]. Because there are 209 PCB congeners, it is a time consuming and expensive task to carry out such 514 calibrations, using the full set of PCB congeners, for daily laboratory practice.…”

Section: Introductionmentioning

confidence: 99%

On the use of reference standards for quantitative trace analysis of PCBs by HRGC. Analyses of technical PCB formulations by HRGC/FID

Krupčík

Kočan²,

Petrı́k³

et al. 1992

Chromatographia

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How do the substituents affect and regulate the relative retention times of polychlorinated biphenyls during gas chromatography?

Jiang

2015

Journal of Chemometrics

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The effects and regulatory actions of the polychlorinated biphenyls (PCBs) substituent characteristics on their relative retention times (RRTs) during gas chromatography were analyzed based on known experimental RRTs of 209 PCB congeners and biphenyl; the substituent characteristics used for this analysis included the total amount of substituents, the similarity between two phenyl rings in a single PCB congener, the substituents distribution in single phenyl ring, the main/second-order interactions effects at each position, and the combined effect of two phenyl rings. At last, the universality of regulation was validated on other experimental conditions. Among them, the full factorial experimental design included 10 factors correlated with each substituent position and two levels (0, 1) were initially applied to the domains of the substituent characteristics. The obtained results have revealed that increasing the total amount of substituents can increase the RRTs of PCBs linearly, but similarities between the two rings cannot control the RRTs effectively. Meanwhile, the more compact the substituent distributions on a single phenyl ring are, the bigger the RRTs of PCBs are. Based on a full factorial experimental design, the overall important trend for each position is as follows: para > meta > ortho and the main regulatory substituents for the second-order interaction effects are distributed in the same phenyl ring in the following sequence: N o > N m > N p . The congener with two perpendicular phenyl rings exhibits a milder combined effect on RRTs and smaller RRT relatively. The regulation has a good universality among different experimental conditions, revealing the dominant effect of substituent characteristics on RRTs of PCBs.

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Characterization and determination of PCB isomers by high resolution gas chromatography and HRGC/mass spectrometry

Cited by 26 publications

References 13 publications

Reference standards for quantitative trace analysis of PCB's by GC. Technical PCB formulations for the calibration of ECD and MSD responses

Reference standards for quantitative trace analysis of PCB's by GC. Technical PCB formulations for the calibration of ECD and MSD responses

On the use of reference standards for quantitative trace analysis of PCBs by HRGC. Analyses of technical PCB formulations by HRGC/FID

How do the substituents affect and regulate the relative retention times of polychlorinated biphenyls during gas chromatography?

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