Characterization and distribution of mechanically competent mineralized tissue in micropores of β-tricalcium phosphate bone substitutes

Multimodal analysis of in vivo resorbable CaP bone substitutes by combining histology, SEM, and microcomputed tomography data

“…The evolutional behavior of the repair process observed from the periphery rings to the center of the defect (Figure ) was consistent with other studies . Specifically, the bone, that is, the SAF and thickness of both CSB and macro‐bone were higher at the outer rings and decreased constantly toward the center of the bone defect (Tables and ).…”

“…The SAF of the micro‐bone is in the same order of magnitude as the macro‐bone. These findings are consistent with the results of Bohner et al Needless to say, this study provided the surface fraction not only of the ceramic remnants but also of the ceramic resorption. More samples and further investigation are required to study the pore effects and further interaction between the micro‐, macro‐bone, and ceramic resorption.…”

“…In earlier studies, cells and bony tissues were identified in the microporous space of bone substitutes. More recently, Bohner et al discovered and demonstrated the ingrowth of mechanically competent mineralized bone tissue in pores as small as 1 μm. To further understand the role of structured porosities in the healing process of bone defects, this study used high‐resolution TBH images and accurately characterized the material phases, including the micro‐bone found the micro‐porous space of the bone substitute.…”

“…In other words, the micro‐bone was centripetally still seeding toward the center of the substitute and progressed faster than the macro‐bone. These results corroborate the findings of Bohner et al It is therefore hypothesized that the micro‐bone formation is of great relevance for the bone healing process, particularly at early implantation stages and the onset of it. The resorption was consistent among the two groups [Figure (d)], being in the range of 10%–25% in the central area and outer boundaries of the defect, respectively.…”

Monodisperse Branched Molybdenum‐Based Bioactive Nanoparticles Significantly Promote Osteogenic Differentiation of Adipose‐Derived Stem Cells

“…Relative to conventional bioactive factors, recently bioactive materials, which can efficiently regulate the cell behavior and tissue regeneration, have been developed through their optimized design for the structure‐composition . The bioactive materials were also developed for improving the osteogenic differentiation of stem cells . For example, bioactive silicate‐based biomaterials and bioactive glasses (BGs) have shown their inherent osteogenic differentiation ability for both BMSCs and ADSCs .…”