Characterization and DNA methylation modulatory activity of gold nanoparticles synthesized by Pseudoalteromonas strain

Patil, Yugandhara M; Rajpathak, Shriram N.; Deobagkar, Deepti D.

doi:10.1007/s12038-018-9842-6

Cited by 18 publications

(7 citation statements)

References 62 publications

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“…Sooklert et al [ 23 ] found reduced global DNA methylation 72 h after exposure of human kidney embryonic HEK293 cells to 100 µg/mL of gold nanoparticles (Au-NPs). Similar findings of DNA demethylating activity of AuNPs were reported by Patil et al [ 30 ]; however, no changes to the extent of global DNA methylation were found in Au-NPs-treated SK-BR-3 human breast cancer cells [ 31 ], HepG2 human liver cancer cells [ 32 ], or MRC5 human fetal fibroblasts [ 33 ]. Likewise, no changes in the DNA methylation status of the down-regulated PROS1 gene were found in Au-NPs-treated MRC5 cells [ 33 ].…”

Section: Dna Methylation Alterations Induced By Exposure To Nanomatersupporting

confidence: 80%

Epigenetic Effects of Nanomaterials and Nanoparticles

Pogribna

Hammons

2021

J Nanobiotechnol

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The rise of nanotechnology and widespread use of engineered nanomaterials in everyday human life has led to concerns regarding their potential effect on human health. Adverse effects of nanomaterials and nanoparticles on various molecular and cellular alterations have been well-studied. In contrast, the role of epigenetic alterations in their toxicity remains relatively unexplored. This review summarizes current evidence of alterations in cytosine DNA methylation and histone modifications in response to nanomaterials and nanoparticles exposures in vivo and in vitro. This review also highlights existing knowledge gaps regarding the role of epigenetic alterations in nanomaterials and nanoparticles toxicity. Additionally, the role of epigenetic changes as potential translational biomarkers for detecting adverse effects of nanomaterials and nanoparticles is discussed.

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Section: Dna Methylation Alterations Induced By Exposure To Nanomatersupporting

confidence: 80%

Epigenetic Effects of Nanomaterials and Nanoparticles

Pogribna

Hammons

2021

J Nanobiotechnol

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“…In recent years, research on NP synthesis has mainly focused on green synthesis using bacteria [73,118] and plants [119][120][121][122]. For example, the marine extremophilic bacteria Pseudoalteromonas was used to obtain Au NPs with non-cytotoxic, non-genotoxic and non-oxidative stress generated over a range of concentrations but provoking alterations in DNA methylation and in the expression of DNA methyltransferase genes [118]. Plants such as Curcuma wenyujin extract [119], Chenopodium formosanum shell extract [120], Dillenia indica leaf aqueous extract, or Annona muricate leaf extracts were also used [123].…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

et al. 2020

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Many investigations have pointed out widespread use of medical nanosystems in various domains of dentistry such as prevention, prognosis, care, tissue regeneration, and restoration. The progress of oral medicine nanosystems for individual prophylaxis is significant for ensuring bacterial symbiosis and high-quality oral health. Nanomaterials in oral cosmetics are used in toothpaste and other mouthwash to improve oral healthcare performance. These processes cover nanoparticles and nanoparticle-based materials, especially domains of application related to biofilm management in cariology and periodontology. Likewise, nanoparticles have been integrated in diverse cosmetic produces for the care of enamel remineralization and dental hypersensitivity. This review summarizes the indications and applications of several widely employed nanoparticles in oral cosmetics, and describes the potential clinical implementation of nanoparticles as anti-microbial, anti-inflammatory, and remineralizing agents in the prevention of dental caries, hypersensitivity, and periodontitis.

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“…The development of non-toxic, reliable, biologically compatible and environment-friendly processes for the synthesis of nanoparticles 16,17 is, therefore, of broad interest. During the last decade, it has been shown that many biological systems, including plants 15,18 , algae 19 , bacteria 20,21 , fungi 22,23 and human cells 24,25 can transform inorganic metal ions into metal nanoparticles through the reducibility of molecules and substances present in these organisms. The production of nanoparticles using plants has advantages, such as low cultivation costs, short production time, safety and the ability to increase production volumes, making them an attractive platform for the synthesis of metallic nanoparticles 15,18 .…”

Section: Introductionmentioning

confidence: 99%

Controlled biosynthesis of gold nanoparticles with Coffea arabica using factorial design

Keijok

Pereira

Alvarez

et al. 2019

Sci Rep

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Green synthesis of metallic nanoparticles has become incredibly popular, mainly by minimizing problems of environmental contamination and by being able to reduce, stabilize and potentially functionalize nanomaterials. Such compounds have possible applications in various areas, e.g., pharmaceuticals (drug delivery systems, cosmetics), textile industry (clothing with antimicrobial properties), diagnostic medicine (imaging, high efficiency biosensors), energy (solar panels), bioremediation, among others. However, the lack of reproducibility and information on the control mechanisms during synthesis have made the application of green-synthesized nanoparticles unfeasible. Thus, this study proposed the investigation of the main mechanisms affecting synthesis control, using factorial design for the preparation of gold nanoparticles with extract of Coffea arabica. We obtained stable (Zeta Potential, UV-vis and DLS), monodisperse, and quasi-spherical (TEM) nanoparticles, which presented adsorbed aromatic molecules (FTIR and RAMAN) and defined crystal structure (XRD), proving that the plant extract acted as a reducing agent, as well as a stabilizer and functionalizer for the synthesized nanostructures. The factorial design employed here to obtain gold nanoparticles with Coffea arabica extract allowed for a controlled and reproducible synthesis, enabling new possibilities for the application in several fields.

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Characterization and DNA methylation modulatory activity of gold nanoparticles synthesized by Pseudoalteromonas strain

Cited by 18 publications

References 62 publications

Epigenetic Effects of Nanomaterials and Nanoparticles

Epigenetic Effects of Nanomaterials and Nanoparticles

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

Controlled biosynthesis of gold nanoparticles with Coffea arabica using factorial design

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