Characterization and evaluation of cytotoxic and apoptotic effects of green synthesis of silver nanoparticles using Artemisia Ciniformis on human gastric adenocarcinoma

Aslany, Shahrzad; Tafvizi, Farzaneh; Naseh, Vahid

doi:10.1016/j.mtcomm.2020.101011

Cited by 46 publications

(22 citation statements)

References 38 publications

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“…In this regard, they have investigated the inhibitory effect of synthesized nanoparticles on gastric cancer cell lines by MTT assay (Figure 9). Results suggested that cell proliferation has been significantly decreased at 12.5, 25, 50 and 100 μg/ml concentration which also confirms that biosynthesized of silver nanoparticles with a concentration of 100 μg/ml had the highest inhibition of cell proliferation (Aslany et al, 2020).…”

Section: Cytotoxic Activitysupporting

confidence: 63%

A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications

Arif

Uddin

2020

Med Devices & Sens

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Green chemistry is the significant field of research as it offers simple, cost-effective, easy, biocompatible and eco-friendly methods for the synthesis of nanomaterials. With the development of nanotechnology, the synthesis of silver nanoparticles (AgNPs) has become important areas of research due to their various applications in industrial, pharmacological and medicinal fields as they exhibited good antibacterial, antifungal, antioxidant, anti-inflammatory, antiviral, anticoagulant, thrombolytic, cytotoxic and photocatalytic properties due to their chemical stability and good biocompatibility.How to cite this article: Arif R, Uddin R. A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications.

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Section: Cytotoxic Activitysupporting

confidence: 63%

A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications

Arif

Uddin

2020

Med Devices & Sens

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“…Downregulation of cyclin D1 stopped the cells at the G0/G1 phase and prevented their progression to the next phases. Apoptosis is evoked in arrested cells by increasing caspase 3/9 (Rahimivand et al 2020 ; Fard et al 2018 ; Aslany et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

Noorbazargan¹,

amintehrani²,

Dolatabadi³

et al. 2021

AMB Expr

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The current study evaluated the anti-cancer properties of bio-functionalized silver nanoparticles fabricated by Juniperus chinensis leaf extracts. The nanoparticles were characterized by scanning electron microscopy, transmission electron microscopy, UV–visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, dynamic light scattering, Zeta potential and X-ray spectroscopy. Further, this study elucidated the cellular and molecular mechanisms of nanoparticles for anti-proliferative and apoptotic effects on human lung cancer cells (A549) and compared them with commercial drug cisplatin. The size of the spherical nanoparticle was 12.96 nm with negative zeta potential. Up-regulation of caspase 3,9 and p53, Annexin V-FITC/PI, DAPI staining, and ROS production indicated the remarkable apoptotic effect of AgNPs compared to cisplatin. Moreover, down-regulation of MMP2/MMP9 scratch and matrigel assays revealed anti-metastatic properties of AgNPs. Cell cycle analysis and downregulation of cyclin D1 indicated cancer cell cessation in the G0/G1 phase. Overall, the results revealed that the green-synthetized AgNPs had anti-metastasis and anti-proliferation effects on lung cancer cells in comparison to cisplatin with lower side effects on the normal cell line.

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“…The shifts in the positions of bands and the disappearance of some peaks in the IR spectrum of synthesized mace-AgNPs indicated the role of OH (hydroxyl) phenols, alcohols, and the carbonyl group of amines in the capping and reduction of silver ions to AgNPs. Carbonyl groups in proteins and hydroxyl groups in alcohols have a strong ability to bind to metals, implying the formation of a layer around the metal NPs [42,59], resulting in capping and preventing the agglomeration of NPs [59,60].…”

Section: The Ftir Spectrum Of Mace Extract and Synthesized Mace-agnpsmentioning

confidence: 99%

Antifungal, Antibacterial, and Cytotoxic Activities of Silver Nanoparticles Synthesized from Aqueous Extracts of Mace-Arils of Myristica fragrans

et al. 2021

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In the present study, mace-mediated silver nanoparticles (mace-AgNPs) were synthesized, characterized, and evaluated against an array of pathogenic microorganisms. Mace, the arils of Myristica fragrans, are a rich source of several bioactive compounds, including polyphenols and aromatic compounds. During nano synthesis, the bioactive compounds in mace aqueous extracts serve as excellent bio reductants, stabilizers, and capping agents. The UV-VIS spectroscopy of the synthesized NPs showed an intense and broad SPR absorption peak at 456 nm. Dynamic light scattering (DLS) analysis showed the size with a Z average of 50 nm, while transmission electron microscopy (TEM) studies depicted the round shape and small size of the NPs, which ranged between 5–28 nm. The peaks related to important functional groups, such as phenols, alcohols, carbonyl groups, amides, alkanes and alkenes, were obtained on a Fourier-transform infrared spectroscopy (FTIR) spectrum. The peak at 3 keV on the energy dispersive X-ray spectrum (EDX) validated the presence of silver (Ag). Mace-silver nanoparticles exhibited potent antifungal and antibacterial activity against several pathogenic microorganisms. Additionally, the synthesized mace-AgNPs displayed an excellent cytotoxic effect against the human cervical cancer cell line. The mace-AgNPs demonstrated robust antibacterial, antifungal, and cytotoxic activity, indicating that the mace-AgNPs might be used in the agrochemical industry, pharmaceutical industry, and biomedical applications. However, future studies to understand its mode of action are needed.

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Characterization and evaluation of cytotoxic and apoptotic effects of green synthesis of silver nanoparticles using Artemisia Ciniformis on human gastric adenocarcinoma

Cited by 46 publications

References 38 publications

A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications

A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

Antifungal, Antibacterial, and Cytotoxic Activities of Silver Nanoparticles Synthesized from Aqueous Extracts of Mace-Arils of Myristica fragrans

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