Characterization and Function of T Cell Fcγ Receptor

Fridman, Wolf‐Herman; Rabourdin–Combe, Chantal; Néauport–Sautès, Catherine; Gisler, Roland H.

doi:10.1111/j.1600-065x.1981.tb01047.x

Cited by 143 publications

(36 citation statements)

References 120 publications

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“…Immunoglobulin-binding factor(s) [IBF(s)] that inhibit the differentiation of B cells to pfc have been described (7,8). Further studies of this factor by Fridman et al (9) demonstrated that IBF is the soluble form of Fcy receptor expressed on a T-cell subset. More recently, Yodoi et al (10,11) reported that IgE induces expression of FcE receptors and production of IgE-suppressive factors by T cells.…”

mentioning

confidence: 99%

Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors.

Löwy¹,

Brézin²,

Néauport–Sautès³

et al. 1983

Proc. Natl. Acad. Sci. U.S.A.

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T2D4, a T-cell hybrid, spontaneously secretes suppressive immunoglobulin factor(s); when incubated with purified monoclonal mouse immunoglobulins, this hybrid produces high levels of immunoglobulin-binding factors specific for the subclass of the inducing immunoglobulin. Thus, we were able to induce the production of IgGI-or IgG2-specific inhibitory factors by the same T2D4 T-cell hybrid. These subclass-specific suppressive factors bind selectively to the IgGI or IgG2 subclasses and inhibit specifically the secretion of antibodies of the corresponding subclass. Our results favor a model of negative regulation of isotype expression in which a given isotype triggers suppressor mechanism(s) specifically inhibiting its production.It has been established that B cells are not precommitted for the secretion of a given isotype (1, 2). In some experiments, 106 spleen cells from DNP-Ova-immunized animals were used, and results were similar. pfc were measured on day 5. IBF-containing samples were added at various dilutions at the initiation of culture. In some instances the suppressor effects were also tested in a cooperative response between poly(Glu,Ala,Tyr)-primed lymph node cells and DNPprimed B cells as described (6).IgGI, IgG2a, IgG2b, and IgA pfc Assays. Hemolytic plaque assays were performed as described (6). IgGI 2323The publication costs ofthis article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisenent" in accordance with 18 U. S. C. §1734 solely to indicate this fact.

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mentioning

confidence: 99%

Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors.

Löwy¹,

Brézin²,

Néauport–Sautès³

et al. 1983

Proc. Natl. Acad. Sci. U.S.A.

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“…Suemura et al (23) reported that an IgE-specific suppressive factor ("IgE-TsF") was absorbed by an alloantiserum specific for determinants of the (KABJE)d region (23). IgG-BF derived from H-2k and H-2d mouse T cells and an H-2k T-cell hybridoma were absorbed by anti-Ia antisera specific for the appropriate la haplotype (24,25). However, the 8.3 IgE-BF sequence shares no homology with class II gene products (10), and genes encoding rodent IgE-BF are members of a multigene family that is not related to genes of the major histocompatibility complex (12).…”

Section: Resultsmentioning

confidence: 99%

Potentiating and suppressive IgE-binding factors are expressed by a single cloned gene.

Martens¹,

Jardieu²,

Trounstine³

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

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“…Alcoholic patients have increased serum immunoglobulin concentrations [Lundy et al, 1975;Bjorkholm, 1980], Theoretically, reduced T-suppressor function could be the cause [Smith et al, 1980], However, the present study shows that the total num ber of cells with receptor for the Fc part of IgG is not altered by ethanol. This may indicate that also the number of T cells with Fey receptor, that is the T-suppressor cells [Moretta et al, 1977;Fridman et al, 1981], is unchanged.…”

Section: Discussionmentioning

confidence: 99%

In vitro Effect of Ethanol on Subpopulations of Human Blood Mononuclear Cells

Gilhus

Matre

1982

Int Arch Allergy Immunol

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Mononuclear cells from 10 healthy blood donors were incubated with ethanol at 37°C for 30 min. An ethanol concentration of 10.0 g/l reduced the percentage of active E rosette-forming cells (E RFC) from 25.0 ± 12.1 to 16.218.7, and the percentage of total E RFC from 70.3 ± 8.5 to 59.7 ± 13.5 (p <0.01 for both). The percentage of cells with phagocytizing capacity was reduced from 11.7 ± 5.4 to 7.0 ± 5.0 by the ethanol treatment (p <0.01). Incubation with ethanol at a concentration of 1.0 g/l also significantly reduced the number of active and total E RFC and of phagocytizing cells. Ethanol at a concentration of 0.1 g/l did not influence these cell subpopulations. The number of EA RFC and EAC RFC were not influenced by ethanol.

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Characterization and Function of T Cell Fcγ Receptor

Cited by 143 publications

References 120 publications

Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors.

Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors.

Potentiating and suppressive IgE-binding factors are expressed by a single cloned gene.

In vitro Effect of Ethanol on Subpopulations of Human Blood Mononuclear Cells

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