Characterization and Hepatoprotections of Ganoderma lucidum Polysaccharides against Multiple Organ Dysfunction Syndrome in Mice

Abstract

Background. The liver is one of the most commonly affected organs in multiple organ dysfunction syndrome (MODS). In recent years, there have been many studies on Ganoderma lucidum polysaccharides (GLP), but the role of GLP in MODS is still unclear. The purpose of this work was to explore the antioxidant, anti-inflammatory, and protective effects of GLP on the liver in MODS model mice. Methods. The characteristic properties of GLP were processed by physicochemical analysis. The MODS models were successfully established with intraperitoneal injection of zymosan in Kunming strain mice. The antioxidant, anti-inflammatory, and hepatoprotective effects of GLP were processed both in vitro and in vivo by evaluating the oxidative parameters, inflammatory factors, and liver pathological observations. Results. The characterization analysis revealed that GLP was a pyranose mainly composed of glucose with the molecular weights (Mw) of 8309 Da. The experimental results proved that GLP had potential hepatoprotection possibly by improving the antioxidant status (scavenging excessive oxygen radicals, increasing the antioxidant enzyme activities, and reducing the lipid peroxide), alleviating the inflammatory response (reducing the inflammatory factor levels), and guaranteeing the liver functions. Conclusions. This research suggested that GLP had the potential to be developed as a natural medicine for the treatment of multiple organ failure.

Inhibitory effect of polysaccharides extracted from Changbai Mountain Ganoderma lucidum on periodontal inflammation

“…The above results indicated that CGLP was successfully extracted with moderate molecular weight, which may have good biological activity (S. Y [ 36 ]. Compared with the GLPs extracted by Zhang Yiwen [ 37 ] and Zhou Dong [ 38 ], CGLP has obvious differences in monosaccharide composition and polysaccharide molecular weight, indicating that the composition of GLPs differ according to the Ganoderma lucidum species, place of origin, and extraction method [ 39 , 40 ]. The CGLP extracted in this experiment may contain new polysaccharide components and structures.…”

Rich d-Fructose-Containing Polysaccharide Isolated from Myxopyrum smilacifolium Roots toward a Superior Antioxidant Biomaterial

“…sobolifera polysaccharides (IC 50 of 0.97 mg/mL) . Moreover, the found DPPH radical scavenging activity of the PS-MSR is higher than those of both the Ganoderma lucidum polysaccharides . The mentioned pieces of evidence suggest a great antioxidant capability of the PS-MSR sample toward antioxidant properties of rich d -fructose-containing polysaccharides, which has been explored from the roots of M.…”

Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum

“…The long-term effects of diabetes reveal the dysfunction and failure of many organs [ 20 ]. Many experiments have shown that animals with induced diabetes have a higher level of oxidative stress and redox imbalance is closely related to disease development [ 35 ].…”

“…However, after applying the polysaccharide (GLPs) to a group of animals, the ultrastructure of the mitochondria of the pancreatic islet cells was maintained by restoring the redox balance [ 35 ]. Excessive production of ROS in cells damages the mitochondrial membrane, oxidizes proteins, introduces mutations into DNA, which ultimately causes mitochondrial dysfunction [ 20 , 72 ]. Most of the endogenous ROS are of mitochondrial origin and indirectly contribute to the development of insulin resistance [ 73 , 74 ].…”