Characterization and immunostimulatory activity of an (1→6)-a-d-glucan from the root of Ipomoea batatas

Zhao, Guohua; Kan, Jianquan; Li, Zhixiao; Zong-dao, Chen

doi:10.1016/j.intimp.2005.03.012

Cited by 100 publications

(45 citation statements)

References 36 publications

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“…The study to investigate the tolerability, efficacy and mode of action of Caiapo extract on metabolic control in type 2 diabetic patients confirmed the beneficial effects of Caiapo on plasma glucose as well as cholesterol levels (Ludvik et al, 2002;2003;. The polysaccharide PSPP (purified sweet potato polysaccharide) isolated from the roots of I. batatas improve the immune system when tested in rats and could be regarded as a biological response modifier (Zhao et al, 2005). Other study confirmed than the extract from baked sweet potato showed potential cancer-preventing effects.…”

Section: Stansmentioning

confidence: 79%

“…With regard to these nutritional purposes, it is necessary highlight the importance of the I. batatas (L.) Lam. This species originated from Central America, was widely cultivated and consumed almost throughout the world (Zhao et al, 2005;Bovell-Benjamin, 2007). I. aquática Forsk is consumed as food in Sri Lanka, Hong Kong, Taiwan e China (Prasad et al, 2005a;Malalavidhane et al, 2000).…”

Section: Traditional Usesmentioning

confidence: 99%

See 1 more Smart Citation

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

Meira¹,

Silva²,

David³

et al. 2012

Rev. bras. farmacogn.

170

120

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Approximately 600-700 species of Ipomoea, Convolvulaceae, are found throughout tropical and subtropical regions of the world. Several of those species have been used as ornamental plants, food, medicines or in religious ritual. The present work reviews the traditional uses, chemistry and biological activities of Ipomoea species and illustrates the potential of the genus as a source of therapeutic agents. These species are used in different parts of the world for the treatment of several diseases, such as, diabetes, hypertension, dysentery, constipation, fatigue, arthritis, rheumatism, hydrocephaly, meningitis, kidney ailments and infl ammations. Some of these species showed antimicrobial, analgesic, spasmolitic, spasmogenic, hypoglycemic, hypotensive, anticoagulant, anti-infl ammatory, psychotomimetic and anticancer activities. Alkaloids, phenolics compounds and glycolipids are the most common biologically active constituents from these plant extracts.

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Section: Stansmentioning

confidence: 79%

Section: Traditional Usesmentioning

confidence: 99%

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

Meira¹,

Silva²,

David³

et al. 2012

Rev. bras. farmacogn.

170

120

View full text Add to dashboard Cite

show abstract

“…The 1 H NMR and 13 C NMR data for DNP are shown in Table 1 [33][34][35][36][37][38][39][40][41][42]. Based on the data available in the literature, chemical shifts between ␦98 and 103 ppm are a typical feature of the C-1 in ␣-glycosidic linkages, whereas in the case of ␤-glycosidic linkages signals would be expected between ␦103 and 106 ppm [43,44].…”

Section: Nmr Analysis Of Dnpmentioning

confidence: 99%

In vitro antioxidant activities of a water-soluble polysaccharide derived from Dendrobium nobile Lindl. extracts

Luo

Zhou

et al. 2009

International Journal of Biological Macromolecules

127

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“…The present data demonstrated that, as with G. lucidum, PFTS increased peritoneal macrophage phagocytosis and the rate of lymphocyte transformation. In this line, a dose-dependent manner of purified sweet potato polysaccharide has been demonstrated to affect the phagocytic function (27).…”

Section: Discussionmentioning

confidence: 96%

Potato freeze‑thaw solution enhances immune function and antitumor activity in?vivo

Shen

Péng

et al. 2017

Oncol Lett

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Abstract. Although potato extract, derived from various methods, exhibits anticancer, antiviral and anti-parasite activities in vitro and in vivo, the bioactivity of potato solution remains unclear using the freeze-thaw extraction method granted by the State Intellectual Property Office of China. In the present study, a potato freeze-thaw solution (PFTS) was fed to mice with ascites tumor that were pre-treated with cyclophosphamide. The numbers of peripheral white blood cells (WBCs), macrophage phagocytosis, lymphocyte transformation and survival of mice were measured. While mice injected with cyclophosphamide exhibited decreased counts of peripheral WBCs, treatment of the cyclophosphamide-injected mice with PFTS for 10 days significantly increased the number of peripheral WBCs and reversed WBC counts to the normal level, a comparable effect to that of Ganoderma lucidum. In addition, treatment with PFTS for 20 days significantly enhanced peritoneal macrophage phagocytosis and lymphocyte transformation. Lastly, PFTS was noticed to prolong the survival of tumor-bearing mice when compared with that of control mice. Collectively, these data suggested that PFTS, at least in part, enhances immune function and possesses antitumor activity. IntroductionAlthough there have been various improvements in detection, diagnosis and treatment, cancer remains the number two cause of mortality in the world, and accounts for a higher number of mortalities than heart disease in those under 85 years of age (1). One of the biggest challenges currently in cancer treatment is to provide effective anticancer therapy without substantial adverse effects, while simultaneously minimizing toxicity. Considering the severe side effects of chemotherapy, studies have been increasingly focusing on the anticancer potential of various vegetables, including potatoes (2,3).Potatoes are one of the most commonly consumed vegetables worldwide and are a good source of antioxidants, including phenolic compounds, vitamin C and carotenoids (4). Previous studies have demonstrated that potato extract (PE) exhibits anticancer, antiviral and anti-parasite activities in vitro and in vivo (5-7). Cheng et al (8) observed that rhamnogalacturonan I domain-rich pectin from potato inhibits the proliferation of human colon cancer HT-29 cells and induces significant G2/M cell cycle arrest. Additionally, Yan et al (9) and Gundala et al (10) have reported that chlorogenic acid, the predominant phenolic compound in potato, inhibits carcinogenesis in liver and prostate cancer cells in vitro and in vivo.Studies on the anticancer properties of potato have utilized PEs derived from various methods (6,11,12). In a comparative analysis of eight phytoplankton chlorophyll-extraction methods (13), it has been shown that the freeze-thaw method produces high quality and stable phytoplankton chlorophyll, and is convenient to use. The authors of the present study successfully patented the ῾potato freeze-thaw solution (PFTS)' in the national patented invention (grant

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Characterization and immunostimulatory activity of an (1→6)-a-d-glucan from the root of Ipomoea batatas

Cited by 100 publications

References 36 publications

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

In vitro antioxidant activities of a water-soluble polysaccharide derived from Dendrobium nobile Lindl. extracts

Potato freeze‑thaw solution enhances immune function and antitumor activity in?vivo

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