The use of titanium and titanium-based alloys with applications in implantology and dentistry has made remarkable progress in the promotion of new technologies and new materials that have been developed in recent years. This is justified thanks to their excellent mechanical, physical, and biological performance. Today's generation promotes new titanium alloys, with nontoxic elements and long-term performance and without rejection of the human body. This book chapter describes new original compositions of Ti-based alloys for medical applications, with improved properties compared to existing classical alloys (C.p. Ti, Ti6Al4V, CoCrMo, etc.). The addition of nontoxic elements such as Mo, Si, Zr, and Ta brings benefits as reduced modulus of elasticity, increased corrosion resistance, and improved biocompatibility.