2008
DOI: 10.1080/10837450802244843
|View full text |Cite
|
Sign up to set email alerts
|

Characterization and Physical Stability of Spray Dried Solid Dispersions of Probucol and PVP-K30

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

3
36
0

Year Published

2009
2009
2024
2024

Publication Types

Select...
9
1

Relationship

1
9

Authors

Journals

citations
Cited by 61 publications
(39 citation statements)
references
References 22 publications
3
36
0
Order By: Relevance
“…11) Thybo et al reported on the characterization and physical stability of spray-dried solid dispersions of probucol and PVP K30. 12) We found that in solid dispersion systems of probucol and PVP prepared by the coprecipitation method, 13,14) probucol dissolution was markedly increased. 8) Although probucol has been used in the treatment of hypercholesterolemia, the pharmacokinetics and pharmacodynamics of the drug are still unknown.…”
Section: -7)mentioning
confidence: 92%
“…11) Thybo et al reported on the characterization and physical stability of spray-dried solid dispersions of probucol and PVP K30. 12) We found that in solid dispersion systems of probucol and PVP prepared by the coprecipitation method, 13,14) probucol dissolution was markedly increased. 8) Although probucol has been used in the treatment of hypercholesterolemia, the pharmacokinetics and pharmacodynamics of the drug are still unknown.…”
Section: -7)mentioning
confidence: 92%
“…1), molecular weight MW = 516.844 g mol À1 , CAS [23,288-49-5], displays two polymorphic forms [8]; the most stable has a melting point in the vicinity of T m = 125 C [8][9][10]. Our probucol samples were from Sigma-Aldrich, product n P9672, and were used without further purification.…”
Section: Sample Preparationmentioning
confidence: 99%
“…In at least two of the cases in this study, namely, Probucol and Ibuprofen, amorphous forms of the drugs have previously been produced by spray drying and mixing with a stabilizing agent. Although Probucol rapidly crystallizes from saturated solutions of ethanol or acetone into one of two polymorphs [25], an amorphous form of the drug has been stabilized by mixing it with a hydrophilic polymer and spray drying [26]. Similarly, Ibuprofen readily crystallizes from an ethanol solution [27], however, a stabilized amorphous form of this drug has also been obtained by cospraying with mesoporous submicron particles to yield an enhanced dissolution rate [28].…”
Section: Fig 2 Insertmentioning
confidence: 99%