Enhanced Bioavailability of Probucol Following the Administration of Solid Dispersion Systems of Probucol-Polyvinylpyrrolidone in Rabbits

G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol

“…Some PB nano-formulations, such as solid dispersions [5] and nanoself-emulsifying delivery systems [6] have been studied and reported. These nano-formulations improved PB water solubility and cellular uptake to some extent, but many problems remained to be solved, including low PB loading capacity, storage stability, carrier aging, potential toxicity from residual organic solvent, and gastrointestinal mucosal injury caused by surfactants.…”

<p>Bio Micro-Nano Technologies of Antioxidants Optimised Their Pharmacological and Cellular Effects, ex vivo, in Pancreatic β-Cells</p>

“…Variation in gut absorption of PB can be due to variation in expression of gut proteins responsible for PB uptake, or the current formulations having unideal targeted delivery properties resulting in inconsistent uptake of PB and poor bioavailability. 11 In one study, Rinninger, et al showed that specific protein transporters can have significant influence on the rate of PB cellular uptake. 12 In another study, Ma, et al showed that the transporter ABCB1 exerted direct cellular and biological effects which significantly impacted PB cellular permeation, efficacy and safety profiles.…”

Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3&beta;, 12&beta;, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats

“…Numerous approaches have been reported to enhance water solubility of hydrophobic drugs, such as salt formation, solid dispersion,17 encapsulation in cyclodextrins,18 nanoparticles,19 and lipid and surfactant-based dispersions 20. Phospholipids constitute a major part of the cell membrane and have many advantages as a carrier system, thus gaining increasing attention.…”