Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3&amp;beta;, 12&amp;beta;, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats

Zhang, Xiangrong; Zhang, Yi; Guo, Shuang; Bai, Feifei; Wu, Tong; Zhao, Yuqing

doi:10.2147/dddt.s114374

Cited by 22 publications

(7 citation statements)

References 30 publications

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“…A nanoemulsion loaded with a 25-OCH 3 -PPD phospholipid complex was also developed. After the oral administration of the nanoemulsion and the suspension of 25-OCH 3 -PPD in rats, peak plasma concentration and area under the curve (0-24 h) of the nanoemulsion of 25-OCH 3 -PPD-phospholipid complex were 3.9-and 3.5-fold higher than those of free compound [26]. Furthermore, the molecular interactions between 25-OCH 3 -PPD and phospholipid 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) were investigated by using the Langmuir film balance technique.…”

Section: The Pharmacokinetics Of 25-och 3 -Ppdmentioning

confidence: 92%

25-Methoxyl-Dammarane-3β, 12β, 20-Triol, A Ginseng Saponin Derivative and an Anticancer Agent: In Vitro and In Vivo Activities, Molecular Mechanism of Action, Pharmacokinetics and Structural Modification

Wu¹,

Ding²,

Wang³

et al. 2017

Med chem (Los Angeles)

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12β, -PPD), a dammarane-type triterpene sapogenin isolated from Panax notoginseng, has shown strong antitumor effects in various human cancer cell lines, including prostate cancer, lung cancer, breast cancer, gastric cancer, colorectal cancer, pancreatic cancer, and hepatic fibrosis. This review focuses on the progress of research into 25-OCH 3 -PPD and its derivatives in cancer therapy, including in vitro and in vivo activities, structure-activity relationships, and the molecular mechanisms of action. In addition, we also summarized a method to evaluate the oral subchronic toxicity, improve oral bioavailability, and establish quality control standards for 25-OCH 3 -PPD. In this review, we have provided a detailed discussion of 25-OCH 3 -PPD and supplied a scientific reference for the research and development of 25-OCH 3 -PPD as a potential anticancer drug.

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Section: The Pharmacokinetics Of 25-och 3 -Ppdmentioning

confidence: 92%

25-Methoxyl-Dammarane-3β, 12β, 20-Triol, A Ginseng Saponin Derivative and an Anticancer Agent: In Vitro and In Vivo Activities, Molecular Mechanism of Action, Pharmacokinetics and Structural Modification

Wu¹,

Ding²,

Wang³

et al. 2017

Med chem (Los Angeles)

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“…95 Furthermore, the oral absorption of 25-OCH3-PPD with poor lipophilicity and hydrophilicity could be improved by nanoemulsion loaded with 25-OCH3-PPD-phospholipid complex that was prepared by solvent evaporation. 96…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications

Balusamy

Perumalsamy

Huq

et al. 2023

Medicinal Research Reviews

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Among 17 Panax species identified across the world, Panax ginseng (Korean ginseng), Panax quinquefolius (American ginseng), and Panax notoginseng (Chinese ginseng) are highly recognized for the presence of bioactive compound, ginsenosides and their pharmacological effects. P. ginseng is widely used for synthesis of different types of nanoparticles compared to P. quinquefolius and P. notoginseng. The use of nano‐ginseng could increase the oral bioavailability, membrane permeability, and thus provide effective delivery of ginsenosides to the target sites through transport system. In this review, we explore the synthesis of ginseng nanoparticles using plant extracts from various organs, microbes, and polymers, as well as their biomedical applications. Furthermore, we highlight transporters involved in transport of ginsenoside nanoparticles to the target sites. Size, zeta potential, temperature, and pH are also discussed as the critical parameters affecting the quality of ginseng nanoparticles synthesis.

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“…This approach is helpful for the efficient delivery of poorly soluble natural products that ultimately enhance their use in BC therapy [ 191 ]. Another nano-emulsion system coated/fabricated with phospholipids was designed to improve the bioavailability of 25-OCH3-PPD [ 192 ]. Cancer stem cells are a major cause of tumor growth initiation and the recurrence of BC due to developing drug resistance.…”

Section: Current Challenges and Future Perspectivesmentioning

confidence: 99%

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

et al. 2022

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Breast cancer (BC) is the second leading cause of death among women, and it has become a global health issue due to the increasing number of cases. Different treatment options, including radiotherapy, surgery, chemotherapy and anti-estrogen therapy, aromatase inhibitors, anti-angiogenesis drugs, and anthracyclines, are available for BC treatment. However, due to its high occurrence and disease progression, effective therapeutic options for metastatic BC are still lacking. Considering this scenario, there is an urgent need for an effective therapeutic strategy to meet the current challenges of BC. Natural products have been screened as anticancer agents as they are cost-effective, possess low toxicity and fewer side effects, and are considered alternative therapeutic options for BC therapy. Natural products showed anticancer activities against BC through the inhibition of angiogenesis, cell migrations, proliferations, and tumor growth; cell cycle arrest by inducing apoptosis and cell death, the downstream regulation of signaling pathways (such as Notch, NF-κB, PI3K/Akt/mTOR, MAPK/ERK, and NFAT-MDM2), and the regulation of EMT processes. Natural products also acted synergistically to overcome the drug resistance issue, thus improving their efficacy as an emerging therapeutic option for BC therapy. This review focused on the emerging roles of novel natural products and derived bioactive compounds as therapeutic agents against BC. The present review also discussed the mechanism of action through signaling pathways and the synergistic approach of natural compounds to improve their efficacy. We discussed the recent in vivo and in vitro studies for exploring the overexpression of oncogenes in the case of BC and the current status of newly discovered natural products in clinical investigations.

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Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats

Cited by 22 publications

References 30 publications

25-Methoxyl-Dammarane-3β, 12β, 20-Triol, A Ginseng Saponin Derivative and an Anticancer Agent: In Vitro and In Vivo Activities, Molecular Mechanism of Action, Pharmacokinetics and Structural Modification

25-Methoxyl-Dammarane-3β, 12β, 20-Triol, A Ginseng Saponin Derivative and an Anticancer Agent: In Vitro and In Vivo Activities, Molecular Mechanism of Action, Pharmacokinetics and Structural Modification

A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

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