Characterization Methods: Physical and Chemical Characterization Techniques

Borgos, Sven Even F.

doi:10.1002/9783527800681.ch7

Cited by 2 publications

(1 citation statement)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nanomedicine-specific analytical challenges have a profound impact on the applicability of these medicines in the clinical setting. The European Commission has acknowledged the lack of established robust and fit-to-purpose methods to provide reliable preclinical data represents the bottleneck in the process of bringing promising nanomedicines to the market—regardless of the target site [ 173 ]. This has evoked the interest of the regulatory stakeholders, supporting further development of certain more sophisticated techniques.…”

Section: Discussionmentioning

confidence: 99%

Parenteral Lipid-Based Nanoparticles for CNS Disorders: Integrating Various Facets of Preclinical Evaluation towards More Effective Clinical Translation

et al. 2023

View full text Add to dashboard Cite

Contemporary trends in combinatorial chemistry and the design of pharmaceuticals targeting brain disorders have favored the development of drug candidates with increased lipophilicity and poorer water solubility, with the expected improvement in delivery across the blood–brain barrier (BBB). The growing availability of innovative excipients/ligands allowing improved brain targeting and controlled drug release makes the lipid nanocarriers a reasonable choice to overcome the factors impeding drug delivery through the BBB. However, a wide variety of methods, study designs and experimental conditions utilized in the literature hinder their systematic comparison, and thus slows the advances in brain-targeting by lipid-based nanoparticles. This review provides an overview of the methods most commonly utilized during the preclinical testing of liposomes, nanoemulsions, solid lipid nanoparticles and nanostructured lipid carriers intended for the treatment of various CNS disorders via the parenteral route. In order to fully elucidate the structure, stability, safety profiles, biodistribution, metabolism, pharmacokinetics and immunological effects of such lipid-based nanoparticles, a transdisciplinary approach to preclinical characterization is mandatory, covering a comprehensive set of physical, chemical, in vitro and in vivo biological testing.

show abstract

Section: Discussionmentioning

confidence: 99%