Characterization of 133Xe gas washout in pulmonary emphysema with dynamic 133Xe SPECT functional images

Suga, Kazuyoshi; Kawakami, Yoshiyuki; Yamashita, Tomio; Zaki, Mohammed; Matsunaga, Naofumi

doi:10.1097/01.mnm.0000188222.07204.62

Cited by 8 publications

(4 citation statements)

References 32 publications

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“…To evaluate lung growth, we focused on MTT values, which are used as a marker of emphysematous change [16,17]. Higher MTT values mean greater emphysematous change; lower MTT values mean less emphysematous change.…”

Section: Discussionmentioning

confidence: 99%

Radionuclide imaging study of long-term pulmonary function after lobectomy in children with congenital cystic lung disease

Kono

Kamagata

Hirobe

et al. 2009

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 99%

Radionuclide imaging study of long-term pulmonary function after lobectomy in children with congenital cystic lung disease

Kono

Kamagata

Hirobe

et al. 2009

Journal of Pediatric Surgery

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“…[4][5][6][7][8] Functional lung imaging has long been known to be sensitive to early disease-related changes, 9,10 and includes computed tomography (CT) parametric response map (PRM) for inspiration-to-expiration registration, 11,12 as well as techniques that use inhaled gases to provide maps of lung ventilation. Included in this latter group are ventilation/perfusion single photon emission computed tomography (SPECT), [13][14][15] xenon-enhanced dual-energy (XeDE) CT, [16][17][18][19][20] and hyper-polarized noblegas magnetic resonance imaging (MRI). 21,22 Hyper-polarized noble-gas MRI [22][23][24] is sensitive to early disease-related changes and can predict respiratory exacerbation.…”

Section: Introductionmentioning

confidence: 99%

“…Xenon-enhanced dual-energy (DE) CT is more economical than MRIbased techniques, but the associated radiation dose of ∼5 mSv for single-breath-hold protocols 16,18,27 potentially precludes its use for longitudinal monitoring of disease progression. While low-dose CT and ultralow-dose CT can reduce patient dose to ∼1 and ∼0.2 mSv for single-energy un-enhanced chest CT, 28 these approaches have not been applied to Xeenhanced DE CT. Ventilation/Perfusion SPECT can classify the severity of functional abnormalities and is sensitive to early COPD, [13][14][15] but requires administration of a radiotracer in a nuclear medicine department and, like CT, is associated with high radiation doses. Finally, the CT PRM approach has the advantage of not requiring inhaled gases, however, acquisitions are required at full inspiration and full expiration.…”

Section: Introductionmentioning

confidence: 99%

Xenon‐enhanced dual‐energy tomosynthesis for functional imaging of respiratory disease—Concept and phantom study

Tanguay

Basharat

2022

Medical Physics

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Background Xenon‐enhanced dual‐energy (DE) computed tomography (CT) and hyperpolarized noble‐gas magnetic resonance imaging (MRI) provide maps of lung ventilation that can be used to detect chronic obstructive pulmonary disease (COPD) early in its development and predict respiratory exacerbations. However, xenon‐enhanced DE‐CT requires high radiation doses and hyper‐polarized noble‐gas MRI is expensive and only available at a handful of institutions globally. Purpose To present xenon‐enhanced dual‐energy tomosynthesis (XeDET) for low‐dose, low‐cost functional imaging of respiratory disease in an experimental phantom study. Methods We propose using digital tomosynthesis to produce Xe‐enhanced low‐energy (LE) and high‐energy (HE) coronal images. DE subtraction of the LE and HE images is used to suppress soft tissues. We used an imaging phantom to investigate image quality in terms of the area under the reciever operating characteristic curve (AUC) for the Non‐PreWhitening model observer with an Eye filter and internal noise (NPWEi). The phantom simulated anatomic clutter due to lung parenchyma and attenuation due to soft tissue and lung tissue. Aluminum slats were used to simulate rib structures. A stepwedge consisting of an acrylic casing with sealed cylindrical air‐filled cavities was used to simulate ventilation defects with step thicknesses of 0.5, 1, and 2 cm and cylindrical radii of 0.5, 0.75, and 1 cm. The phantom was ventilated with Xe and projection data were acquired using a flat‐panel detector, a tube‐voltage combination of 60/140 kV with 1.2 mm of copper filtration on the HE spectrum and an angular range of ±15∘$\pm 15^{\circ}$ in 1° increments. The AUC of a NPWEi observer that has access only to a single coronal slice was calculated from measurements of the three‐dimensional noise power spectrum and signal template. The AUC was calculated as a function of ventilation defect thickness and radius for total patient entrance air kermas ranging from 1.42 to 2.84 mGy with and without rib‐simulating Al slats. For the AUC analysis, the observer internal noise level was obtained from an ad hoc calibration to a high‐dose data set. Results XeDET was able to suppress parenchyma‐simulating clutter in coronal images enabling visualization of the simulated ventilation defects, but the limited angle acquisition resulted in residual clutter due to out‐of‐plane bone‐mimmicking structures. The signal power of the defects increased linearly with defect radius and showed a ten‐fold to fifteen‐fold increase in signal power when the defect thickness increased from 0.5 to 2 cm. These trends agreed with theoretical predictions. Along the depth dimension, the power of the defects decreased exponentially with distance from the center of the defects with full‐width half maxima that varied from 1.85 to 2.85 cm depending on the defect thickness and radius. The AUCs of the 1‐cm‐radius defect that was 2 cm in thickness ranged from good (0.8–0.9) to excellent (0.9–1.0) over the range of air kermas considered. Conclusions Xen...

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“…Among these noble gases, xenon is the most frequently investigated and widely applied in medicine. Xenon has been used as an anesthetic [2], to treat brain and heart injuries due to its neuroprotection and cardioprotection [3,4] and in single photon emission computed tomography (SPECT) [5]. …”

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confidence: 99%

Xenon preconditioning: molecular mechanisms and biological effects

Liu

Chen³

et al. 2013

Medical Gas Research

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Xenon is one of noble gases and has been recognized as an anesthetic for more than 50 years. Xenon possesses many of the characteristics of an ideal anesthetic, but it is not widely applied in clinical practice mainly because of its high cost. In recent years, numerous studies have demonstrated that xenon as an anesthetic can exert neuroprotective and cardioprotective effects in different models. Moreover, xenon has been applied in the preconditioning, and the neuroprotective and cardioprotective effects of xenon preconditioning have been investigated in a lot of studies in which some mechanisms related to these protections are proposed. In this review, we summarized these mechanisms and the biological effects of xenon preconditioning.

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Characterization of 133Xe gas washout in pulmonary emphysema with dynamic 133Xe SPECT functional images

Cited by 8 publications

References 32 publications

Radionuclide imaging study of long-term pulmonary function after lobectomy in children with congenital cystic lung disease

Radionuclide imaging study of long-term pulmonary function after lobectomy in children with congenital cystic lung disease

Xenon‐enhanced dual‐energy tomosynthesis for functional imaging of respiratory disease—Concept and phantom study

Xenon preconditioning: molecular mechanisms and biological effects

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