Characterization of a bovine intestinal myofibroblast cell line and stimulation using phytoglycogen-based nanoparticles bound to inosine monophosphate

The sweetest polymer nanoparticles: opportunities ahead for glycogen in nanomedicine

“…The system demonstrated knockdown of MMP-9 of skin wound tissues, with ultimate enhanced wound healing. As an aside, but in a similar vein, Jenik, et al , 45 used inosine monophosphate-conjugated phytoglycogen nanoparticles for enhancing cell proliferation of a bovine intestinal myofibroblast cell line.…”

More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitro

“…In fact, nanoparticles of various compositions have shown promise as carriers of poly inosinic: poly cytidylic acid (pIC), a commercially available viral dsRNA mimic, while effectively stimulating the immune system ( Kim et al, 2017 ; Sokolova et al, 2017 ; Gondan et al, 2018 ). Because nanoparticles of inorganic composition can have negative impacts on cells and their responses ( Jeng and Swanson, 2006 ; Villeret et al, 2018 ; Báez et al, 2021 ; reviewed by Sengul and Asmatulu, 2020 ), optimization with an organic nanoparticle, such as the phytoglycogen nanoparticle (NDX) previously used by our group ( Alkie et al, 2019 ; Jenik et al, 2021a ; Jenik et al, 2021b ), would be ideal. Previous work has shown that this phytoglycogen nanoparticle is non-toxic, can effectively deliver pIC to vertebrate cells, and can successfully limit rhabdovirus replication ( Alkie et al, 2019 ).…”