Characterization of a novel and spontaneous mouse model of inflammatory arthritis

Abstract

Arthritis is a heterogeneous disease comprising a group of inflammatory and non-inflammatory conditions that can cause pain, stiffness and swelling in the joints. Mouse models of rheumatoid arthritis (RA) have been critical for identifying genetic and cellular mechanisms of RA and several new mouse models have been produced. Various methods have been applied to induce experimental models of arthritis in animals that would provide important insights into the etiopathogenetic mechanisms of human RA. Adipue and colleagues recently discovered that mice in their breeding colony spontaneously developed inflamed joints reminiscent of RA and may, therefore, have found a new model to examine pathogenic mechanisms and test new treatments for this human inflammatory disease.

Self-Catalyzing Chemiluminescence of Luminol-Diazonium Ion and Its Application for Catalyst-Free Hydrogen Peroxide Detection and Rat Arthritis Imaging

“…The detection sensitivity to 1 O 2 is confirmed by the finding of remarkable CL enhancement to sub-10 –7 M level 1 O 2 (Figure S14). A PIA rat model was prepared in this work for its many similarities to human rheumatic arthritis . Imaging results are shown in Figure A, where clear CL evidence indicates the severe inflammation at the ankle join, metatarsal joint, and interphalangeal joint of the right hind limb rather than the entire paw swelling by macroscopic observation (Figure B).…”

Role of Cysteine Cathepsins in Joint Inflammation and Destruction in Human Rheumatoid Arthritis and Associated Animal Models

“…It is important to select the right animal model for RA to address a specific scientific question. The repertory of animal models of RA includes among others adjuvant arthritis, antigen-induced arthritis (AIA), collagen-induced arthritis (CIA), and human TNF-transgenic (hTNFtg) mice [78,80,81,82]. Each of these animal models only reflects a few of the clinical aspects of the human disease.…”

“…Especially the investigation of cysteine cathepsin-deficient or -transgenic mice in such models as well as the application of specific inhibitors in arthritic animals enables the understanding of the contribution of individual proteases to the disease outcome. Animal models for human RA can be classified into induced and spontaneous models [82]. It is important to select the right animal model for RA to address a specific scientific question.…”