Gender differences in collagen-induced arthritis (CIA) in mice

Sex differences in long-term effects of collagen-induced arthritis in middle-aged mice

“…In the present study, no significant differences in the locomotor activity of mice were found. In contrast, other studies that assessed the locomotor activity of mice in the CIA model within the first 3 weeks after the booster immunization showed a worsening in mice mobility, which is stated to correlate with arthritic scores (Hartog et al, 2009;Marinov et al, 2022). However, in the present study, when comparing the individual locomotor activity of mice to their trabecular bone density, a positive correlation was observed, indicating worsening of mobility in mice with lower bone density.…”

“…Surprisingly, while the incidence of arthritis symptoms was similar in both sexes, an earlier onset of arthritis and more severe long-term effects of CIA on joints were observed in middle-aged male CIA mice, which do not recapitulate the situation observed in human RA. The underlying mechanisms responsible for the observed sex differences in the CIA model in mice and humans with RA remain elusive ( Kovacs and Olsen, 2011 ; Smolen et al, 2018 ; Marinov et al, 2022 ). However, despite the contrasting sex differences between human RA and the CIA mouse model, it is believed that in both, variations within the sex chromosomes and the influence of sex hormones on the immune system play a pivotal role in shaping the observed disparities between the sexes ( Holmdahl et al, 1986 ; Gerosa et al, 2008 ; Taneja, 2018 ).…”

“…4.4 Sex differences in RA and the CIA mouse model RA exhibits a peak incidence around the age of 50 years, with women being 2-3 times more likely to develop the condition compared to men (Gerosa et al, 2008;van der Woude & van der Helm-van Mil, 2018). In the CIA mouse model on the other hand, sex differences have been predominantly described as male mice exhibiting a higher incidence and severity of arthritis symptoms compared to female mice (Holmdahl et al, 1986;Kim & Kim, 2020;Luan et al, 2021;Marinov et al, 2022). However, there is a notable gap of data pertaining to the application of this model in mice at the age that mimics the typical onset age of human RA and data regarding the long-term effects of the CIA model is also lacking in scientific literature.…”

“…Most often, young male mice (8–12 weeks old) are used because of the potential influence of female sex hormones and age-related systemic changes on the model ( Brand et al, 2007 ). However, there are also controversies about low to no incidence of arthritis in female mice, lower susceptibility of aged mice, and the development of spontaneous arthritis in male DBA/1J mice older than 4 months ( Holmdahl et al, 1985 ; 1986 ; Brand et al, 2007 ; Braem et al, 2012 ; Marinov et al, 2022 ). However, the course of CIA and its long-term effects on the joints of middle-aged mice need to be investigated in both sexes to better describe the similarities and limitations to the clinical relevance of the CIA model for human RA.…”

Papel da resistina via CAP1 nas alterações vasculares mediadas pelo tecido adiposo perivascular em modelo experimental de artrite reumatoide

“…Devido ao modelo escolhido ser de fase crônica, o acometimento da doença é igualável em ambos os sexos possivelmente pela duração e intensidade do acometimento articular. Enquanto, em outros modelos de AR experimental como a CIA, a susceptibilidade e desenvolvimento da doença é maior em camundongos jovens machos comparados a fêmeas (MARINOV et al, 2021). Por outro lado, a severidade da doença é igual em machos e fêmeas jovens com AIA, porém ao utilizar camundongos mais velhos (18 semanas), a severidade da AIA é maior em camundongos fêmeas ( VAN BEUNINGEN et al, 1989) et al, 2020).…”