2016
DOI: 10.2527/jas.2015-9698
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Characterization of a novel encapsulated oral iron supplement to prevent iron deficiency anemia in neonatal piglets 1

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Cited by 15 publications
(24 citation statements)
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“…To minimize both toxicity of supplemental iron and its capacity to induce hepcidin synthesis, we proposed several modifications of routine procedure of FeDex administration to piglets [8,12]. Furthermore, considering that heme preparations have been successfully used to prevent and treat IDA in humans [16][17][18], dogs [19], and pigs [20,21], we used bovine hemoglobin as heme iron supplement. We showed that oral supplementation of piglets with hemoglobin rescues them from severe IDA observed in non-supplemented animals [22].…”
Section: Introductionmentioning
confidence: 99%
“…To minimize both toxicity of supplemental iron and its capacity to induce hepcidin synthesis, we proposed several modifications of routine procedure of FeDex administration to piglets [8,12]. Furthermore, considering that heme preparations have been successfully used to prevent and treat IDA in humans [16][17][18], dogs [19], and pigs [20,21], we used bovine hemoglobin as heme iron supplement. We showed that oral supplementation of piglets with hemoglobin rescues them from severe IDA observed in non-supplemented animals [22].…”
Section: Introductionmentioning
confidence: 99%
“…En la Figura 2 F se observa el hierro encapsulado como una emulsión, en donde el tamaño de las gotas puede variar 37 , pero mediante el uso de técnicas como baño ultrasónico o sonicación se puede disminuir el tamaño a micras o nanómetros. En la Figura 2 G-I se presentan diferentes micropartículas elaboradas con distintos compuestos de hierro observadas mediante microscopía electrónica de barrido 38,39 . Los tamaños de éstas también son variables (generalmente en micras).…”
Section: Introductionunclassified
“…En relación a los estudios in vivo de productos con hierro encapsulado, algunas de las investigaciones relevantes se presentan en la Tabla 2 38,[46][47][48][49][50][51][52] . Estos productos se han probado en modelos animales como rata y cerdo, como también en humanos.…”
Section: Introductionunclassified
“…Antileo et al (2016) used microparticles made from iron sulphate and porcine erythrocytes for the prevention of anaemia in suckling piglets. They managed to prevent the development of anaemia with this supplement divided into 3 doses.…”
Section: Iron Microparticlesmentioning
confidence: 99%