Characterization of a novel rabbit model of Peyronie’s disease

Gündoğdu, Gökhan; Nguyen, Travis; Namasivayam, Aarthi; Starek, Stephanie; Gelman, Joel; Mauney, Joshua R.

doi:10.1038/s41443-023-00671-y

Cited by 6 publications

(4 citation statements)

References 40 publications

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“…In particular, deregulation of TGF-β1 activity and thereby activation of TGF-β signaling have been strongly linked to the pathogenesis of PD, as described above. Indeed, activation of TGF-β signaling through the subtunical injection of TGF-β1 in rat and rabbit models has been demonstrated to induce PD-like plaque formation in the penis [ 101 , 102 ]. In addition, there are other critical target molecules and signaling cell pathways related to fibrosis, which develops when these interact around the TGF-β signaling pathway.…”

Section: Core Signaling Pathways and Their Crosstalk Involved In Deve...mentioning

confidence: 99%

Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease

Mitsui

Yamabe

Hori

et al. 2023

IJMS

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Peyronie’s disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. In recent years, research into understanding of the detailed mechanisms and risk factors involved in the development of PD has been increasing. In this review, the pathological mechanisms and several closely related signaling pathways, including TGF-β, WNT/β-catenin, Hedgehog, YAP/TAZ, MAPK, ROCK, and PI3K/AKT, are described. Findings regarding cross-talk among these pathways are then discussed to elucidate the complicated cascade behind tunica albuginea fibrosis. Finally, various risk factors including the genes involved in the development of PD are presented and their association with the disease summarized. The purpose of this review is to provide a better understanding regarding the involvement of risk factors in the molecular mechanisms associated with PD pathogenesis, as well as to provide insight into disease prevention and novel therapeutic interventions.

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Section: Core Signaling Pathways and Their Crosstalk Involved In Deve...mentioning

confidence: 99%

Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease

Mitsui

Yamabe

Hori

et al. 2023

IJMS

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“…In particular, deregulation of TGF-β1 activity and thereby activation of TGF-β signaling have been strongly linked to the pathogenesis of PD, as described above. Indeed, activation of TGF-β signaling through the subtunical injec-tion of TGF-β1 in rat and rabbit models has been demonstrated to induce PD-like plaque formation in the penis [101,102]. In addition, there are other critical target molecules and signaling cell pathways related to fibrosis, which develops when these interact around the TGF-β signaling pathway.…”

Section: Core Signaling Pathways and Their Crosstalk Involved In Deve...mentioning

confidence: 99%

Molecular Mechanisms and Risk Factors Related to Pathogenesis of Peyronie's Disease

Mitsui¹,

Yamabe²,

Hori³

et al. 2023

Preprint

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Peyronie's disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. In recent years, understanding of the detailed mechanisms and risk factors involved in development of PD has been increasing. In this review, the pathological mechanisms and several closely related signaling pathways, including TGF-β, WNT/β-catenin, Hedgehog, YAP/TAZ, MAPK, ROCK, and PI3K/AKT, are described. Findings regarding cross-talk among these pathways are then discussed to elucidate the complicated cascade behind tunica albuginea fibrosis. Finally, various risk factors including genetic involved in the development of PD are presented and their association with the disease summarized. The purpose of this review is to provide better understanding regarding involvement of risk factors in the molecular mechanisms associated with PD pathogenesis, as well as provide insight into disease prevention and novel therapeutic interventions.

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“…Of 2490 studies retrieved, 2446 articles were excluded. A total of 44 studies were included in this review 11 , 13–53 which are summarized in Table 1 . Among them, 40 studies used rats only, 1 study used both rats and mice, 1 study used a genetic mouse model, and 2 studies used rabbits ( Table 1 ).…”

Section: General Observationsmentioning

confidence: 99%

“…Mouse, rat, and rabbit models have been utilized to study PD in vivo. 11 , 13–55 Most models rely on inducing fibrosis in TA either by increasing TGF-β1 in TA or by surgical trauma of the TA. The Tight-skin 1 (Tsk) model is the only genetic model for the disease in which PD-like fibrosis develops spontaneously.…”

Section: Introductionmentioning

confidence: 99%

European Society of Sexual Medicine consensus statement on the use of animal models for studying Peyronie’s disease

Castiglione,

Çakır,

Schifano

et al. 2023

Sexual Medicine

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Introduction Animal models are frequently used for translational research in Peyronie’s disease (PD). However, due to lack of availability of guidelines, there is some heterogeneity in study design, data reporting, and outcome measures. Aim This European Society for Sexual Medicine consensus statement aims to provide guidance in utilization of animal models in PD research in a standardized and uniform fashion. Methods PubMed was searched for studies using animal models for PD. The following search terms were used: (“Peyronie’s disease” OR “penile fibrosis” OR “penile curvature” OR “induration penis plastica” OR “erectile dysfunction”) AND (“rodent” OR “mouse” OR “mice” OR “rat” OR “rabbit”). Outcomes This European Society for Sexual Medicine statement describes best practice guidelines for utilization of animals in PD research: power calculation, details of available models, surgical procedures, and measurement techniques, while highlighting possible pitfalls and translational limitations of the models. Results In total, 2490 studies were retrieved and 2446 articles were excluded. A total of 44 studies were included, of which 40 studies used rats, 1 study used both rats and mice, 1 study used a genetic mouse model, and 2 studies used rabbits. A significant number of the studies (70.5%) used transforming growth factor β 1 for induction of fibrosis. Oxford 2011 Levels of Evidence criteria could not be applied due to the nature of the studies. Conclusion Despite certain limitations of PD animal models presented, we aimed to provide guidance for their appropriate use in translational research, with the purpose of improving study quality and reproducibility as well as facilitating interpretation of reported results and conclusions.

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Characterization of a novel rabbit model of Peyronie’s disease

Cited by 6 publications

References 40 publications

Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease

Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease

Molecular Mechanisms and Risk Factors Related to Pathogenesis of Peyronie's Disease

European Society of Sexual Medicine consensus statement on the use of animal models for studying Peyronie’s disease

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