2018
DOI: 10.1242/jcs.211748
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Characterization of a novel RP2–OSTF1 interaction and its implication for actin remodelling

Abstract: Retinitis pigmentosa 2 () is the causative gene for a form of X-linked retinal degeneration. RP2 was previously shown to have GTPase-activating protein (GAP) activity towards the small GTPase ARL3 via its N-terminus, but the function of the C-terminus remains elusive. Here, we report a novel interaction between RP2 and osteoclast-stimulating factor 1 (OSTF1), an intracellular protein that indirectly enhances osteoclast formation and activity and is a negative regulator of cell motility. Moreover, this interact… Show more

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Cited by 8 publications
(5 citation statements)
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References 56 publications
(85 reference statements)
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“…Fission yeast Ank1 phosphorylation sites are reported (Swaffer et al, 2018), but none are analogous to S202 or in proximity to the predicted interaction interfaces. OSTF1 also has additional binding partners, one of which, RP2, is proposed to regulate the subcellular localization of OSTF1 and its ability to bind and regulate Myo1e (Lyraki et al, 2018). Further studies will be needed to elucidate the full set of regulatory mechanisms affecting Ank1/OSTF1-myosin-1 complex formation.…”
Section: Resultsmentioning
confidence: 99%
“…Fission yeast Ank1 phosphorylation sites are reported (Swaffer et al, 2018), but none are analogous to S202 or in proximity to the predicted interaction interfaces. OSTF1 also has additional binding partners, one of which, RP2, is proposed to regulate the subcellular localization of OSTF1 and its ability to bind and regulate Myo1e (Lyraki et al, 2018). Further studies will be needed to elucidate the full set of regulatory mechanisms affecting Ank1/OSTF1-myosin-1 complex formation.…”
Section: Resultsmentioning
confidence: 99%
“…, 2018 ), but none are analogous to S202 or in proximity to the predicted interaction interfaces. OSTF1 also has additional binding partners, one of which, RP2, is proposed to regulate the subcellular localization of OSTF1 and its ability to bind and regulate Myo1e ( Lyraki et al. , 2018 ).…”
Section: Resultsmentioning
confidence: 99%
“…The target genes for MYC approached 4000 in human, that are involved in various cellular processes, including cell cycle, survival, protein synthesis, cell adhesion, cytoskeleton, and metabolism 133 , 134 . It is worth mentioning that HSP90 135 , OSTF1 136 , VDAC2 137 , RPs 138 , 139 , mitochondrial genes 140 , Col2A1 141 , and cytoskeleton-associated proteins 142 144 , are all targets for MYC. Of particular interest, MYC was found to be expressed in bone and required for osteoclast differentiation 145 .…”
Section: Discussionmentioning
confidence: 99%