Characterization of a prolactin gene polymorphism and its associations with systemic lupus erythematosus

HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

“…In our work we studied polymorphisms in three genes (HLA class II, MICA, PRL) located within the susceptible locus for SLE on the chromosome 6 [11,23,28]. Genes in this region show a high level of polymorphism and linkage disequilibrium.…”

“…Lymphocyte PRL synthesis is regulated by alternative, extrapituitary promoter and the G allele of the -1149 G/T SNP of extrapituitary PRL promoter (rs1341239) leads to higher PRL expression [28]. HLA-class II typing was performed using polymerase chain reaction (PCR) with sequence specific primers (SSP-PCR).…”

Biomarkers in systemic lupus erythematosus: I. General overview of biomarkers and their applicability

“…Other genes implicated in terms of a role in disease susceptibility include Hsp70-2 (in African Americans) (83), IL-4 receptor (84), monocyte chemoattractant protein 1 (85), plasminogen activator inhibitor 1 (86,87) ␤ 2 -glycoprotein I (88), osteopontin (89), vitamin D receptor (90), Ets (91), DNase (92), and prolactin (93).…”

The genetics of systemic lupus erythematosus: putting the pieces together

“…Some evidence has been obtained for possible association with SLE and alleles at Bcl-2, CTLA4, the T cell receptors, prolactin, tumor necrosis factor (TNF) and TNF receptors. [92][93][94][95][96][97][98] Even in aggregate, however, these effects are too small to explain the genetics of SLE. Therefore, other genes still remain to be identified.…”