Characterization of a traditional Chinese medicine plant the chloroplast genome of Andrographis paniculata

Abstract

Andrographis paniculata is widely distributed and used in tropical and subtropical regions of Asia. To enhance the development of its medicinal value, we reported and characterized the complete chloroplast genome sequence of A. paniculata in an effort to provide genomic resources useful to promoting its medicinal value and systematic research. The chloroplast genome of Andrographis paniculata was found to possess a total length 150,249 bp with the typical quadripartite structure of angiosperms, respectively. It contained a large single-copy (LSC) region of 82,460 bp, a small single-copy (SSC) region of 17,111 bp and separated by a pair of inverted repeat (IR) regions of 25,339 bp. The chloroplast genome of Andrographis paniculata is composed of 132 individual genes, consisting of 87 protein-coding genes, 37 transfer RNA genes and 8 ribosomal RNA genes. The overall G-C content of the chloroplast genome is 38.4%, A of 45,852 bp (30.5%), T of 46,873 bp (31.2%), C of 29,281 bp (19.5%) and G of 18.8% (28,243 bp). Phylogenetic tree analysis result shown that Andrographis paniculata was clustered to Strobilanthes cusia by the maximum-likelihood (ML) method in this study.

In Silico Drug Repurposing for SARS-CoV-2 Main Proteinase and Spike Proteins

“…A hit that might be worthy of attention, although only identified by the QHD43415 model, is dehydroandrographolide succinate (DAS). DAS is a natural product extracted from Andrographis paniculate , well-known by traditional Chinese medicine . Indeed, while the herb has long been used to treat cold and fever, purified andrographolides, including DAS and analogues, have been prepared and used to treat respiratory diseases. , Antibacterial, antiviral, anti-inflammatory, and immune-stimulatory activities were claimed for DAS, including the inhibition of HIV and H5N1 viruses in vitro . , …”

Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview

“…In Ayurveda, A. paniculata is commonly used to treat sore throat, flu, liver disorders, jaundice, antispasmodic, malaria, eczema, intestinal worm infestation, and gonorrhoea [ 3 , 6 ]. On the other hand, the plant is used to remove body heat such as fevers and toxins, besides treating diarrhea, laryngitis, gastric infections, and inflammation in Chinese Medicine [ 7 , 8 ]. In contemporary pharmacology, A. paniculata acts as an immune system stimulant, treats pharyngotonsillitis, myocardial ischemia, and is anticancer, antimicrobial, anti-inflammatory, anti-HIV, and many more [ 1 , 9 ].…”