Characterization of a wireless implantable infusion micropump for small animal research under simulated in vivo conditions

Cobo, Angelica; Tu, Heidi; Sheybani, Roya; Meng, Ellis

doi:10.1109/biocas.2014.6981734

Cited by 8 publications

(7 citation statements)

References 12 publications

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“…Valves significantly decreased reverse flow compared to a valve less system. We demonstrated that flow rate is not significantly affected by back pressures of up to 20 mmHg (when delivering solutions of 1 cP) or delivering solutions with viscosities of up to 6 cP (data shown in (Cobo, Tu et al 2014)). As expected, micropump flow rate increased with increased environmental temperatures.…”

Section: Discussionmentioning

confidence: 80%

“…Therefore, it is important to investigate the effects of varying the axial separation distance and angular misalignment between the transmitting and receiving coils that can result over the course of drug administration in an animal study. Previously, we presented preliminary results of successful micropump performance in simulated in vivo conditions including delivery against a physiologically relevant back pressure and delivering solutions of differing viscosities (Cobo, Tu et al 2014). Here, we extend this simulated in vivo studies to analyze micropump performance when delivering at body temperature and long term pump functionality when subjected to a simulated in vivo environment (saline soak at body temperature).…”

Section: Experimental Methodsmentioning

confidence: 99%

“…The check valve contributes to accurate dosing and prevents drug contamination with biological fluids during the recombination reaction between electrolysis actuation cycles (Sheybani, Gensler et al 2012). Acute characterization of pump performance was previously presented (Cobo, Tu et al 2014). For this work, the pump performance characterization was extended to simulate in vivo chronic conditions, including those relevant to future studies to deliver agents to combat radiation resistance in a mouse xenograft cancer model.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A wireless implantable micropump for chronic drug infusion against cancer

Cobo

Sheybani

et al. 2016

Sensors and Actuators A: Physical

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We present an implantable micropump with a miniature form factor and completely wireless operation that enables chronic drug administration intended for evaluation and development of cancer therapies in freely moving small research animals such as rodents. The low power electrolysis actuator avoids the need for heavy implantable batteries. The infusion system features a class E inductive powering system that provides on-demand activation of the pump as well as remote adjustment of the delivery regimen without animal handling. Micropump performance was demonstrated using a model anti-cancer application in which daily doses of 30 μL were supplied for several weeks with less than 6% variation in flow rate within a single pump and less than 8% variation across different pumps. Pumping under different back pressure, viscosity, and temperature conditions were investigated; parameters were chosen so as to mimic in vivo conditions. In benchtop tests under simulated in vivo conditions, micropumps provided consistent and reliable performance over a period of 30 days with less than 4% flow rate variation. The demonstrated prototype has potential to provide a practical solution for remote chronic administration of drugs to ambulatory small animals for research as well as drug discovery and development applications.

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Section: Discussionmentioning

confidence: 80%

Section: Experimental Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A wireless implantable micropump for chronic drug infusion against cancer

Cobo

Sheybani

et al. 2016

Sensors and Actuators A: Physical

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“…18 on-demand wirelessly. 6 The system, shown in Fig. 11a, uses electrolysis, because it has large driving forces, low power consumption, low heat generation, and the ability to control the electronic flow rate.…”

Section: Pumpsmentioning

confidence: 99%

Applications of Wireless Power Transfer in Medicine: State-of-the-Art Reviews

Moore

Castellanos

Xu³

et al. 2018

Ann Biomed Eng

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Magnetic resonance within the field of wireless power transfer has seen an increase in popularity over the past decades. This rise can be attributed to the technological advances of electronics and the increased efficiency of popular battery technologies. The same principles of electromagnetic theory can be applied to the medical field. Several medical devices intended for use inside the body use batteries and electrical circuits that could be powered wirelessly. Other medical devices limit the mobility or make patients uncomfortable while in use. The fundamental theory of electromagnetics can improve the field by solving some of these problems. This survey paper summarizes the recent uses and discoveries of wireless power in the medical field. A comprehensive search for papers was conducted using engineering search engines and included papers from related conferences. During the initial search, 247 papers were found then nonrelevant papers were eliminated to leave only suitable material. Seventeen relevant journal papers and/or conference papers were found, then separated into defined categories: Implants, Pumps, Ultrasound Imaging, and Gastrointestinal (GI) Endoscopy. The approach and methods for each paper were analyzed and compared yielding a comprehensive review of these state of the art technologies.

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“…A bellow membrane is a thin-walled corrugated tube designed to expand or bend easily under longitudinal forces, internal pressure or bending moments [2]. Bellows membranes have been used in a wide range of applications such as thermopneumatic actuators [3], electrostatic actuator [4], microfluidics [5], fuel storage and delivery [6], micro-gripper [7], electrochemical actuators [8], [9], integrated drug delivery actuator [10], [11], artificial tracheal graft [12] and artificial rubber muscle [13]. However, despite the immense progress in various applications, the existing fabrication methods and techniques are still complex, not suitable for mass production, and are especially limited to the macroscale size [3]- [13].…”

Section: Introductionmentioning

confidence: 99%

3-D Printed Biocompatible Micro-Bellows Membranes

Moussi

Kosel

2018

J. Microelectromech. Syst.

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Bellows membranes are essential elements in many actuator devices. Currently, the size, shape, and dimensions of bellows membranes are limited by the fabrication process constraints. Miniaturizing the bellows membranes is a prerequisite for the development of integrated systems with novel capabilities as needed, for example, in advanced biomedical devices. Using a two-photon polymerization, 3-D printing technique, we present a high-resolution, high-yield, and customizable manufacturing process to produce Parylene C micro-bellows. An optimization of the crucial design parameters is performed using finite element modeling from which designs with high deflection and low stress were obtained. Different micro-bellows designs are fabricated and characterized. The total volume of the fabricated models ranges from 3 to 0.3 mm 3 and the minimum feature size is 60 µm. The achieved cumulative deflection ranges from 300 to 570 µm.

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Characterization of a wireless implantable infusion micropump for small animal research under simulated in vivo conditions

Cited by 8 publications

References 12 publications

A wireless implantable micropump for chronic drug infusion against cancer

A wireless implantable micropump for chronic drug infusion against cancer

Applications of Wireless Power Transfer in Medicine: State-of-the-Art Reviews

3-D Printed Biocompatible Micro-Bellows Membranes

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